Acetazolamide_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetazolamide perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Acetazolamide_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0687471
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0572352
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0476386
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.047539
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.044182
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0430583
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0373525
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.034502
APP amyloid beta (A4) precursor protein 0.032687
TRIO trio Rho guanine nucleotide exchange factor 0.0319447
KDM3A lysine (K)-specific demethylase 3A 0.0314304
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0305509
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0301072
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0300711
DENND4A DENN/MADD domain containing 4A 0.0298036
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0297828
SPAG9 sperm associated antigen 9 0.0293707
SAMD4A sterile alpha motif domain containing 4A 0.028657
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0281553
EIF4A3 eukaryotic translation initiation factor 4A3 0.0279072
RPS4Y1 ribosomal protein S4, Y-linked 1 0.027699
ERRFI1 ERBB receptor feedback inhibitor 1 0.0273167
MAPK8 mitogen-activated protein kinase 8 0.0267956
FGB fibrinogen beta chain 0.0266594
IER3 immediate early response 3 0.0263648
BRD2 bromodomain containing 2 0.026217
BCLAF1 BCL2-associated transcription factor 1 0.0260453
HSPA8 heat shock 70kDa protein 8 0.0258118
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0253108
BZW1 basic leucine zipper and W2 domains 1 0.0251675
MACF1 microtubule-actin crosslinking factor 1 0.0250602
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0250545
CYTH1 cytohesin 1 0.025039
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0250387
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.024903
WDR43 WD repeat domain 43 0.0245252
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0241869
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0236607
THBS1 thrombospondin 1 0.0230792
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0227492
RBM39 RNA binding motif protein 39 0.0225943
ANKRD11 ankyrin repeat domain 11 0.0225601
USP36 ubiquitin specific peptidase 36 0.0223152
CAVIN1 caveolae associated protein 1 0.0222715
ARF4 ADP-ribosylation factor 4 0.0220427
TM4SF1 transmembrane 4 L six family member 1 0.0219779
YME1L1 YME1-like 1 ATPase 0.0219567
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0218431
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.021696
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0214239
AKAP12 A kinase (PRKA) anchor protein 12 0.021374
NOP58 NOP58 ribonucleoprotein 0.0213078
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0212697
CANX calnexin 0.0212312
EIF4A1 eukaryotic translation initiation factor 4A1 0.0212216
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0211985
MARCHF6 membrane associated ring-CH-type finger 6 0.021149
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0208683
MATR3 matrin 3 0.020792
COPA coatomer protein complex, subunit alpha 0.0207898
ELOVL5 ELOVL fatty acid elongase 5 0.020428
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0203512
CYRIB CYFIP related Rac1 interactor B 0.0201953
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0199595
ANXA1 annexin A1 0.0199338
CXCL8 chemokine (C-X-C motif) ligand 8 0.0198029
MYH9 myosin, heavy chain 9, non-muscle 0.0197598
NAMPT nicotinamide phosphoribosyltransferase 0.0197056
FAM168A family with sequence similarity 168, member A 0.0193349
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0193307
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.019325
OSBPL9 oxysterol binding protein-like 9 0.0191208
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.018977
BASP1 brain abundant, membrane attached signal protein 1 0.0188427
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0188092
RPL3 ribosomal protein L3 0.0186403
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0185941
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0185476
EIF1 eukaryotic translation initiation factor 1 0.0184919
CASC3 cancer susceptibility candidate 3 0.01838
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0183507
ZC3H11A zinc finger CCCH-type containing 11A 0.0182486
ZFAND3 zinc finger, AN1-type domain 3 0.0182302
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.01811
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0178965
SRSF5 serine/arginine-rich splicing factor 5 0.017834
BTBD7 BTB (POZ) domain containing 7 0.0176644
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0174759
SAFB2 scaffold attachment factor B2 0.0174711
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0174354
PTK2 protein tyrosine kinase 2 0.0172452
SRRM1 serine/arginine repetitive matrix 1 0.0170653
ILF2 interleukin enhancer binding factor 2 0.0170183
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0169496
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0166613
RSRC2 arginine/serine-rich coiled-coil 2 0.0165442
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 0.0163788
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0163712
TP53BP1 tumor protein p53 binding protein 1 0.0163215
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0163066

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.257957
MT2A metallothionein 2A -0.144816
TMSB10 thymosin beta 10 -0.116995
FTL ferritin, light polypeptide -0.116041
PDE4D phosphodiesterase 4D, cAMP-specific -0.100578
GRAMD1B GRAM domain containing 1B -0.0940346
PM20D1 peptidase M20 domain containing 1 -0.0841514
VIM vimentin -0.0713239
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0645032
TXNRD1 thioredoxin reductase 1 -0.0582813
RPL19 ribosomal protein L19 -0.0552471
FTH1 ferritin, heavy polypeptide 1 -0.0524181
WWOX WW domain containing oxidoreductase -0.0432785
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0428079
RPLP0 ribosomal protein, large, P0 -0.0406787
THSD4 thrombospondin, type I, domain containing 4 -0.038296
RPLP1 ribosomal protein, large, P1 -0.0365033
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.036249
RPS19 ribosomal protein S19 -0.0346376
SLC38A2 solute carrier family 38, member 2 -0.0338699
RPL35A ribosomal protein L35a -0.0329885
HMGA1 high mobility group AT-hook 1 -0.032763
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0323108
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0319486
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0310438
RPS29 ribosomal protein S29 -0.0288828
RPL23 ribosomal protein L23 -0.0285894
RPL8 ribosomal protein L8 -0.0278293
NTN4 netrin 4 -0.0266419
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0265488
CMIP c-Maf inducing protein -0.0260708
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0254701
BICC1 BicC family RNA binding protein 1 -0.0251452
PFN1 profilin 1 -0.0249447
RPS25 ribosomal protein S25 -0.0247673
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0238262
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0237207
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0234668
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0229653
C15ORF48 chromosome 15 open reading frame 48 -0.0228356
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0227805
RPS23 ribosomal protein S23 -0.0227133
EGR1 early growth response 1 -0.022707
RAD51B RAD51 paralog B -0.02263
EFNA5 ephrin-A5 -0.0224794
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.022436
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0222197
S100A10 S100 calcium binding protein A10 -0.0217507
BIRC3 baculoviral IAP repeat containing 3 -0.0215552
RPS15 ribosomal protein S15 -0.0210227
PDE8A phosphodiesterase 8A -0.0209492
RPL28 ribosomal protein L28 -0.0204404
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0204209
RPL36 ribosomal protein L36 -0.0199651
MKI67 marker of proliferation Ki-67 -0.019939
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0198403
OSMR oncostatin M receptor -0.0194768
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0191637
ANKRD28 ankyrin repeat domain 28 -0.0191116
ADGRG6 adhesion G protein-coupled receptor G6 -0.0190623
MBNL1 muscleblind-like splicing regulator 1 -0.0190244
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0189926
VDAC1 voltage-dependent anion channel 1 -0.0188086
RPS5 ribosomal protein S5 -0.0186692
RPS8 ribosomal protein S8 -0.0186541
RPS16 ribosomal protein S16 -0.0186385
CENPF centromere protein F, 350/400kDa -0.0177636
TTC28 tetratricopeptide repeat domain 28 -0.0177081
NNMT nicotinamide N-methyltransferase -0.0176874
TBC1D5 TBC1 domain family, member 5 -0.0175139
RPS12 ribosomal protein S12 -0.0172558
NFIA nuclear factor I/A -0.0171685
HMGB1 high mobility group box 1 -0.0171664
RPL31 ribosomal protein L31 -0.016548
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0164272
RPL9 ribosomal protein L9 -0.0162923
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0162631
S100A9 S100 calcium binding protein A9 -0.0161847
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0161553
RTN4 reticulon 4 -0.0158968
RPS21 ribosomal protein S21 -0.015867
NHSL1 NHS-like 1 -0.0158316
AHR aryl hydrocarbon receptor -0.0155042
MAML3 mastermind-like 3 (Drosophila) -0.0152715
ZNF804A zinc finger protein 804A -0.0152403
NCOA7 nuclear receptor coactivator 7 -0.0150897
PDLIM5 PDZ and LIM domain 5 -0.0150353
FAM135A family with sequence similarity 135, member A -0.0149762
TMOD3 tropomodulin 3 (ubiquitous) -0.0149684
RPS20 ribosomal protein S20 -0.0148796
ELL2 elongation factor, RNA polymerase II, 2 -0.0148428
ATP5F1E ATP synthase F1 subunit epsilon -0.0147293
TRAPPC9 trafficking protein particle complex 9 -0.0146525
BPTF bromodomain PHD finger transcription factor -0.0146302
TNPO1 transportin 1 -0.0145521
EHBP1 EH domain binding protein 1 -0.0142438
PRR16 proline rich 16 -0.014153
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.0141436
NLN neurolysin (metallopeptidase M3 family) -0.0140117
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0139829