Acetazolamide_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetazolamide perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetazolamide_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.0983347
FN1 fibronectin 1 0.097358
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0805656
AKAP12 A kinase (PRKA) anchor protein 12 0.0744441
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0721757
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0708628
KMT2E lysine (K)-specific methyltransferase 2E 0.06684
PTMA prothymosin, alpha 0.0656695
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0570598
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0567159
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0557452
ATP13A3 ATPase type 13A3 0.0544241
ANXA1 annexin A1 0.0540913
PNISR PNN-interacting serine/arginine-rich protein 0.0514127
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0506074
EIF1 eukaryotic translation initiation factor 1 0.0502885
THOC2 THO complex 2 0.0501775
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0501537
ZNF292 zinc finger protein 292 0.0499145
PABPC1 poly(A) binding protein, cytoplasmic 1 0.048656
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0482149
RPL12 ribosomal protein L12 0.0463361
SETD5 SET domain containing 5 0.0460226
MT2A metallothionein 2A 0.0457406
RPS6 ribosomal protein S6 0.044667
BIRC6 baculoviral IAP repeat containing 6 0.0438087
RYBP RING1 and YY1 binding protein 0.0434655
TPI1 triosephosphate isomerase 1 0.0431907
ERRFI1 ERBB receptor feedback inhibitor 1 0.0429094
ENO1 enolase 1, (alpha) 0.0428169
RNF145 ring finger protein 145 0.0424966
CANX calnexin 0.0415105
COPA coatomer protein complex, subunit alpha 0.04128
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0411559
ZFP36L1 ZFP36 ring finger protein-like 1 0.0410643
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0408566
PRRC2C proline-rich coiled-coil 2C 0.0397864
CHD9 chromodomain helicase DNA binding protein 9 0.0393883
RPL19 ribosomal protein L19 0.0392742
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.038801
RBM39 RNA binding motif protein 39 0.0385038
SUCO SUN domain containing ossification factor 0.038046
TRIO trio Rho guanine nucleotide exchange factor 0.0367988
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0367764
MATR3 matrin 3 0.0363681
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0358207
WDR45B WD repeat domain 45B 0.0353287
SRRM2 serine/arginine repetitive matrix 2 0.0353125
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0348302
CCNL1 cyclin L1 0.0345708
CDC73 cell division cycle 73 0.034523
CALD1 caldesmon 1 0.0344993
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0343722
COL5A2 collagen, type V, alpha 2 0.0341221
GOLGA4 golgin A4 0.0340949
H3-3B H3.3 histone B 0.0334907
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0334007
SBF2 SET binding factor 2 0.0333049
RPLP1 ribosomal protein, large, P1 0.0332887
FTL ferritin, light polypeptide 0.032928
GPHN gephyrin 0.0326891
FXR1 fragile X mental retardation, autosomal homolog 1 0.0324719
ENAH enabled homolog (Drosophila) 0.0324457
NAP1L1 nucleosome assembly protein 1-like 1 0.0317353
MEF2A myocyte enhancer factor 2A 0.0316161
RPS3 ribosomal protein S3 0.0315527
OGA O-GlcNAcase 0.031484
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0314717
YBX1 Y box binding protein 1 0.0314011
UGCG UDP-glucose ceramide glucosyltransferase 0.0312714
RPS19 ribosomal protein S19 0.0312205
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.030888
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0306093
OSBPL8 oxysterol binding protein-like 8 0.0306049
CERS6 ceramide synthase 6 0.0301733
FOXJ3 forkhead box J3 0.0301062
HOOK2 hook microtubule-tethering protein 2 0.0299827
RAB7A RAB7A, member RAS oncogene family 0.0299645
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0298614
CXCL8 chemokine (C-X-C motif) ligand 8 0.0297846
TMSB10 thymosin beta 10 0.0295536
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0293081
RUNX1 runt-related transcription factor 1 0.0292704
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.029265
GNAS GNAS complex locus 0.028676
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0282395
ETNK1 ethanolamine kinase 1 0.0280751
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0279826
RPL30 ribosomal protein L30 0.0279823
FUBP1 far upstream element (FUSE) binding protein 1 0.027555
S100A6 S100 calcium binding protein A6 0.027501
RSRC2 arginine/serine-rich coiled-coil 2 0.0274273
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0271415
PHF21A PHD finger protein 21A 0.0271158
RFX7 regulatory factor X, 7 0.0270211
DCAF7 DDB1 and CUL4 associated factor 7 0.0268803
NUP153 nucleoporin 153kDa 0.0268081
ARHGAP5 Rho GTPase activating protein 5 0.0263561
ADAM9 ADAM metallopeptidase domain 9 0.0263442
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.026323

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.245242
BACE2 beta-site APP-cleaving enzyme 2 -0.159217
MYO1E myosin IE -0.135211
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.12984
MUC16 mucin 16, cell surface associated -0.128512
LMO7 LIM domain 7 -0.12849
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.101032
LAMB3 laminin, beta 3 -0.0907317
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0896353
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0873773
CEMIP cell migration inducing protein, hyaluronan binding -0.0849796
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0841707
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0836319
IFIH1 interferon induced with helicase C domain 1 -0.0835012
EXT1 exostosin glycosyltransferase 1 -0.0807826
RIGI RNA sensor RIG-I -0.0792452
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0791945
KYNU kynureninase -0.0751569
IGF1R insulin-like growth factor 1 receptor -0.0738508
F3 coagulation factor III (thromboplastin, tissue factor) -0.0728989
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0717162
PDE4D phosphodiesterase 4D, cAMP-specific -0.0700615
LIMCH1 LIM and calponin homology domains 1 -0.068014
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0676062
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0663536
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0660643
MACF1 microtubule-actin crosslinking factor 1 -0.0598348
SAMD4A sterile alpha motif domain containing 4A -0.0595781
SVIL supervillin -0.0593595
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0590907
RBM47 RNA binding motif protein 47 -0.0587489
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0577182
MYO5B myosin VB -0.057643
ATOSA atos homolog A -0.0573106
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0569831
SMOC1 SPARC related modular calcium binding 1 -0.0564313
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0558747
JUP junction plakoglobin -0.0546039
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0542158
EGR1 early growth response 1 -0.0520345
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0517584
AKAP13 A kinase (PRKA) anchor protein 13 -0.0507977
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.049966
PICALM phosphatidylinositol binding clathrin assembly protein -0.0499326
NCOR2 nuclear receptor corepressor 2 -0.0496936
TMOD3 tropomodulin 3 (ubiquitous) -0.0494161
TJP1 tight junction protein 1 -0.048608
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.04852
TUFT1 tuftelin 1 -0.0475769
BMAL2 basic helix-loop-helix ARNT like 2 -0.0473244
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0463621
PTPRM protein tyrosine phosphatase, receptor type, M -0.0462684
CLIP1 CAP-GLY domain containing linker protein 1 -0.0461721
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0454521
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0449927
ERBIN erbb2 interacting protein -0.0446484
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0441743
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0441284
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0433697
JUN jun proto-oncogene -0.0426094
OASL 2'-5'-oligoadenylate synthetase-like -0.0424754
CSNK1A1 casein kinase 1, alpha 1 -0.0423072
MAML3 mastermind-like 3 (Drosophila) -0.0417156
OSMR oncostatin M receptor -0.0415773
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0415548
ABHD17C abhydrolase domain containing 17C -0.0412981
SMYD3 SET and MYND domain containing 3 -0.0412407
KRT17 keratin 17, type I -0.0410853
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.040937
USP6NL USP6 N-terminal like -0.0405145
AFF1 AF4/FMR2 family, member 1 -0.0402276
ANTXR2 anthrax toxin receptor 2 -0.0399839
SH3PXD2A SH3 and PX domains 2A -0.0399616
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0398034
ABLIM1 actin binding LIM protein 1 -0.0396082
RAI14 retinoic acid induced 14 -0.0395456
SRPK2 SRSF protein kinase 2 -0.0395136
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.03926
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0390977
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0388648
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0382742
C6ORF132 chromosome 6 open reading frame 132 -0.0381187
ZNFX1 zinc finger, NFX1-type containing 1 -0.0376836
PRKCSH protein kinase C substrate 80K-H -0.0369112
REPS1 RALBP1 associated Eps domain containing 1 -0.0367951
TAOK3 TAO kinase 3 -0.0360688
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.035992
SENP6 SUMO1/sentrin specific peptidase 6 -0.0359795
KIF13B kinesin family member 13B -0.0354859
GSK3B glycogen synthase kinase 3 beta -0.0352804
MXD1 MAX dimerization protein 1 -0.0347522
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0345597
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.034092
CATSPERB catsper channel auxiliary subunit beta -0.0338902
EGFR epidermal growth factor receptor -0.033883
CUX1 cut-like homeobox 1 -0.0337738
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.033702
STEAP4 STEAP family member 4 -0.0334926
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0333054
TLK1 tousled-like kinase 1 -0.0329551