Acetazolamide_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetazolamide perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Acetazolamide_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.299731
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.166483
ERRFI1 ERBB receptor feedback inhibitor 1 0.0802735
KDM2A lysine (K)-specific demethylase 2A 0.0723258
OGA O-GlcNAcase 0.0715941
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0640622
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0506953
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0462185
PDE4D phosphodiesterase 4D, cAMP-specific 0.0460389
COPA coatomer protein complex, subunit alpha 0.0444844
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0437006
GOLGA4 golgin A4 0.0416787
TXNRD1 thioredoxin reductase 1 0.0409599
ZCCHC7 zinc finger, CCHC domain containing 7 0.0390355
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0361579
EIF4B eukaryotic translation initiation factor 4B 0.0357224
ANKRD36 ankyrin repeat domain 36 0.0353593
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0348603
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0347482
MACF1 microtubule-actin crosslinking factor 1 0.033387
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0332019
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0331152
WNK1 WNK lysine deficient protein kinase 1 0.0324818
TPM3 tropomyosin 3 0.0322501
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0318755
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0318741
KMT2E lysine (K)-specific methyltransferase 2E 0.0317211
TM4SF1 transmembrane 4 L six family member 1 0.0316399
ZFC3H1 zinc finger, C3H1-type containing 0.031121
SAMD4A sterile alpha motif domain containing 4A 0.0298771
MYH9 myosin, heavy chain 9, non-muscle 0.0297078
CAMTA1 calmodulin binding transcription activator 1 0.0294411
TMEM165 transmembrane protein 165 0.0293258
CTTNBP2NL CTTNBP2 N-terminal like 0.0292282
USP34 ubiquitin specific peptidase 34 0.0291861
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0289796
USP9X ubiquitin specific peptidase 9, X-linked 0.0286425
ADAM17 ADAM metallopeptidase domain 17 0.0285182
R3HDM2 R3H domain containing 2 0.0283868
SEC31A SEC31 homolog A (S. cerevisiae) 0.0280303
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0274319
YBX3 Y box binding protein 3 0.0273614
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.027201
EIF3A eukaryotic translation initiation factor 3, subunit A 0.027146
GOLGB1 golgin B1 0.0265987
CDK19 cyclin-dependent kinase 19 0.0262972
MAPK8 mitogen-activated protein kinase 8 0.0261067
XPO1 exportin 1 0.0260907
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0260627
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0257902
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0257536
FMNL2 formin-like 2 0.0256026
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0255821
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.025573
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0252412
JMJD1C jumonji domain containing 1C 0.0251558
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0246917
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0246087
GIGYF2 GRB10 interacting GYF protein 2 0.0245316
TTC28 tetratricopeptide repeat domain 28 0.0241811
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.024158
ZBTB1 zinc finger and BTB domain containing 1 0.0237597
TTC3 tetratricopeptide repeat domain 3 0.0236986
SET SET nuclear proto-oncogene 0.0235824
SUCO SUN domain containing ossification factor 0.0235462
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0234452
CKAP5 cytoskeleton associated protein 5 0.0233588
WRN Werner syndrome, RecQ helicase-like 0.0233256
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0232636
MAP4 microtubule-associated protein 4 0.0231878
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0229571
PRKCE protein kinase C, epsilon 0.0225549
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0224889
AKAP13 A kinase (PRKA) anchor protein 13 0.0224718
RBM39 RNA binding motif protein 39 0.022412
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0219653
MBD5 methyl-CpG binding domain protein 5 0.021863
KANSL3 KAT8 regulatory NSL complex subunit 3 0.0218377
ATP13A3 ATPase type 13A3 0.0218154
HELB helicase (DNA) B 0.0217566
AVL9 AVL9 homolog (S. cerevisiase) 0.0217405
PPP1R21 protein phosphatase 1, regulatory subunit 21 0.0214802
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0214604
KMT2C lysine (K)-specific methyltransferase 2C 0.0214153
RAD51B RAD51 paralog B 0.0213975
PLCB4 phospholipase C, beta 4 0.0213683
TFCP2 transcription factor CP2 0.0212817
WDPCP WD repeat containing planar cell polarity effector 0.0211366
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0211161
RB1CC1 RB1-inducible coiled-coil 1 0.0209804
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0209255
FNIP1 folliculin interacting protein 1 0.0208752
TOP2B topoisomerase (DNA) II beta 180kDa 0.0208183
DCAF8 DDB1 and CUL4 associated factor 8 0.0207484
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0206835
UBE2H ubiquitin-conjugating enzyme E2H 0.0206113
NIPBL Nipped-B homolog (Drosophila) 0.0204611
ATXN1 ataxin 1 0.0204365
ADAM9 ADAM metallopeptidase domain 9 0.0202972
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.0202884

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.45011
TMSB10 thymosin beta 10 -0.11975
VIM vimentin -0.116718
EGR1 early growth response 1 -0.10351
RPLP1 ribosomal protein, large, P1 -0.075537
RPS8 ribosomal protein S8 -0.0728501
YBX1 Y box binding protein 1 -0.0695031
RPL12 ribosomal protein L12 -0.0683874
RPL35A ribosomal protein L35a -0.0661408
PTMA prothymosin, alpha -0.0646385
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0644372
RPS19 ribosomal protein S19 -0.0605238
RPS27 ribosomal protein S27 -0.0567381
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0559244
RPL37 ribosomal protein L37 -0.0520336
RPL34 ribosomal protein L34 -0.0481403
RPL37A ribosomal protein L37a -0.0481076
RPL8 ribosomal protein L8 -0.0478872
ACTG1 actin gamma 1 -0.0467899
PFN1 profilin 1 -0.0456064
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0448728
RPL19 ribosomal protein L19 -0.0441328
TPT1 tumor protein, translationally-controlled 1 -0.0438605
HMGA1 high mobility group AT-hook 1 -0.0416884
LOC112694756 uncharaterized LOC112694756 -0.0407462
RPL9 ribosomal protein L9 -0.0401976
RACK1 receptor for activated C kinase 1 -0.0397524
EEF2 eukaryotic translation elongation factor 2 -0.0391323
RPS29 ribosomal protein S29 -0.0384594
RPS4X ribosomal protein S4, X-linked -0.0384069
RPS21 ribosomal protein S21 -0.0372906
RPL23 ribosomal protein L23 -0.0368943
RPS6 ribosomal protein S6 -0.0359679
EIF5B eukaryotic translation initiation factor 5B -0.0352963
RPL32 ribosomal protein L32 -0.0346002
RPS15 ribosomal protein S15 -0.0345329
LDHB lactate dehydrogenase B -0.034039
TPI1 triosephosphate isomerase 1 -0.0340301
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0339805
RPL26 ribosomal protein L26 -0.0337937
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0337153
RPL11 ribosomal protein L11 -0.0333701
RPS12 ribosomal protein S12 -0.0328719
RPL5 ribosomal protein L5 -0.0323455
EEF1G eukaryotic translation elongation factor 1 gamma -0.0322493
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0311662
S100A10 S100 calcium binding protein A10 -0.0309407
GNAS GNAS complex locus -0.0305481
SLC38A2 solute carrier family 38, member 2 -0.0303682
RPS20 ribosomal protein S20 -0.0301962
RPS27A ribosomal protein S27a -0.0301505
RPL38 ribosomal protein L38 -0.0298421
RPLP0 ribosomal protein, large, P0 -0.0296775
RPLP2 ribosomal protein, large, P2 -0.0295251
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0294897
ATP5F1E ATP synthase F1 subunit epsilon -0.0293682
DNAH14 dynein, axonemal, heavy chain 14 -0.0291268
RPL36 ribosomal protein L36 -0.0290375
FTL ferritin, light polypeptide -0.028716
RPS14 ribosomal protein S14 -0.0278567
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.027455
NAP1L1 nucleosome assembly protein 1-like 1 -0.0263447
RPL28 ribosomal protein L28 -0.0262914
RPS24 ribosomal protein S24 -0.0261941
POTEF POTE ankyrin domain family, member F -0.0260301
RPS13 ribosomal protein S13 -0.0257424
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.025661
RIMS2 regulating synaptic membrane exocytosis 2 -0.0255949
THSD4 thrombospondin, type I, domain containing 4 -0.0254536
DEK DEK proto-oncogene -0.0251912
EXOC6B exocyst complex component 6B -0.0251294
RPL31 ribosomal protein L31 -0.0249532
RPL27A ribosomal protein L27a -0.024822
THADA thyroid adenoma associated -0.0246443
MYL12B myosin, light chain 12B, regulatory -0.0245325
MT2A metallothionein 2A -0.024061
S100A11 S100 calcium binding protein A11 -0.0237765
WWOX WW domain containing oxidoreductase -0.0237658
CBX3 chromobox homolog 3 -0.0237178
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0235949
PKM pyruvate kinase, muscle -0.0234238
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0233293
SERBP1 SERPINE1 mRNA binding protein 1 -0.023224
NUP155 nucleoporin 155kDa -0.0230913
ZFR zinc finger RNA binding protein -0.0229574
CAMKMT calmodulin-lysine N-methyltransferase -0.0226327
TPM2 tropomyosin 2 (beta) -0.0224969
LOC102724023 ES1 protein homolog, mitochondrial -0.0224727
RPS10 ribosomal protein S10 -0.0223837
ANKRD11 ankyrin repeat domain 11 -0.0219935
RPL27 ribosomal protein L27 -0.021887
STC1 stanniocalcin 1 -0.0218514
GSTP1 glutathione S-transferase pi 1 -0.0218308
EXOC4 exocyst complex component 4 -0.0218254
TUBA1B tubulin, alpha 1b -0.0216605
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0214717
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0210831
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0208972
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0208423
RPL35 ribosomal protein L35 -0.0206079