Acetazolamide_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetazolamide perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetazolamide_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.123789
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.104232
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0990036
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0950785
RNF145 ring finger protein 145 0.0652044
NAMPT nicotinamide phosphoribosyltransferase 0.0638245
FN1 fibronectin 1 0.0608648
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0459684
CCNL1 cyclin L1 0.0455658
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0418828
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0406001
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0403752
FAM13A family with sequence similarity 13, member A 0.0394594
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0388268
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0385801
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0376628
MATR3 matrin 3 0.0376148
HSPA8 heat shock 70kDa protein 8 0.036669
ELL2 elongation factor, RNA polymerase II, 2 0.0366414
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0357336
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0356685
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0347563
KMT2E lysine (K)-specific methyltransferase 2E 0.0346823
UBA6 ubiquitin-like modifier activating enzyme 6 0.0345368
MSN moesin 0.0345222
HMGB2 high mobility group box 2 0.0339309
TFG TRK-fused gene 0.0338233
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0326814
MARCHF6 membrane associated ring-CH-type finger 6 0.0326231
PAPOLA poly(A) polymerase alpha 0.0325421
NCKAP1 NCK-associated protein 1 0.0317656
FXR1 fragile X mental retardation, autosomal homolog 1 0.0316096
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0312264
SET SET nuclear proto-oncogene 0.0311631
NUP58 nucleoporin 58 0.0306253
ASPH aspartate beta-hydroxylase 0.0304451
TPM3 tropomyosin 3 0.030395
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0302455
APLP2 amyloid beta (A4) precursor-like protein 2 0.0298543
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0293688
KDM6A lysine (K)-specific demethylase 6A 0.0293089
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0292509
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0287268
GARS1 glycyl-tRNA synthetase 1 0.0286636
BHLHE40 basic helix-loop-helix family, member e40 0.0281978
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.027944
CDC73 cell division cycle 73 0.0276541
MYH9 myosin, heavy chain 9, non-muscle 0.0267855
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0266179
YTHDC1 YTH domain containing 1 0.0264915
EIF3A eukaryotic translation initiation factor 3, subunit A 0.026454
KTN1 kinectin 1 (kinesin receptor) 0.0261276
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0255501
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0255319
SPTBN1 spectrin, beta, non-erythrocytic 1 0.025485
MSMO1 methylsterol monooxygenase 1 0.0251016
NAP1L1 nucleosome assembly protein 1-like 1 0.0250763
EEF2 eukaryotic translation elongation factor 2 0.0243065
WAC WW domain containing adaptor with coiled-coil 0.024218
GPBP1 GC-rich promoter binding protein 1 0.0239355
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0237734
RBM33 RNA binding motif protein 33 0.0236638
EPS8 epidermal growth factor receptor pathway substrate 8 0.0235795
USP3 ubiquitin specific peptidase 3 0.0233147
ATP13A3 ATPase type 13A3 0.0228094
ZNF292 zinc finger protein 292 0.0226457
RLF rearranged L-myc fusion 0.0226031
ANXA5 annexin A5 0.022533
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0224576
PNISR PNN-interacting serine/arginine-rich protein 0.0221185
ADAM9 ADAM metallopeptidase domain 9 0.0219997
PRRC2C proline-rich coiled-coil 2C 0.0212122
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0210812
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0210684
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.021029
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0209446
EIF4B eukaryotic translation initiation factor 4B 0.0206192
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0205775
FNDC3B fibronectin type III domain containing 3B 0.0205354
RBM39 RNA binding motif protein 39 0.0204533
PCBP2 poly(rC) binding protein 2 0.0204329
PUM2 pumilio RNA-binding family member 2 0.0201756
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0201494
DIAPH1 diaphanous-related formin 1 0.0200805
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0199799
RYK receptor-like tyrosine kinase 0.0199417
ECT2 epithelial cell transforming 2 0.0199044
RAD23B RAD23 homolog B (S. cerevisiae) 0.0196579
IPO7 importin 7 0.0196052
RHEB Ras homolog enriched in brain 0.0195896
MIS18BP1 MIS18 binding protein 1 0.0195196
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0194403
AFDN afadin, adherens junction formation factor 0.0192209
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0189398
PUM1 pumilio RNA-binding family member 1 0.0188363
QKI QKI, KH domain containing, RNA binding 0.0186824
CHD1 chromodomain helicase DNA binding protein 1 0.0185119
RYBP RING1 and YY1 binding protein 0.0183817
ELP2 elongator acetyltransferase complex subunit 2 0.0179707
ANXA1 annexin A1 0.0179684

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.290844
TMSB10 thymosin beta 10 -0.196643
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.194292
ACTG1 actin gamma 1 -0.180758
FTL ferritin, light polypeptide -0.164557
IFI27 interferon, alpha-inducible protein 27 -0.108346
LPP LIM domain containing preferred translocation partner in lipoma -0.0988186
RPL35A ribosomal protein L35a -0.0976013
LAMB3 laminin, beta 3 -0.0936042
FBXO32 F-box protein 32 -0.0905135
NDRG1 N-myc downstream regulated 1 -0.087745
TPT1 tumor protein, translationally-controlled 1 -0.0848935
S100A6 S100 calcium binding protein A6 -0.0825868
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0822957
IFI6 interferon, alpha-inducible protein 6 -0.0813424
EXT1 exostosin glycosyltransferase 1 -0.078739
IGFBP3 insulin-like growth factor binding protein 3 -0.0767071
SOX4 SRY (sex determining region Y)-box 4 -0.0740734
RPL34 ribosomal protein L34 -0.0689373
S100A10 S100 calcium binding protein A10 -0.0677102
LIMCH1 LIM and calponin homology domains 1 -0.0674677
IFI16 interferon, gamma-inducible protein 16 -0.0672896
CSTB cystatin B (stefin B) -0.0666358
LMO7 LIM domain 7 -0.0664225
EFNA5 ephrin-A5 -0.0644759
ISG15 ISG15 ubiquitin-like modifier -0.0631951
RPLP1 ribosomal protein, large, P1 -0.0596425
IFITM3 interferon induced transmembrane protein 3 -0.0593863
HMGA1 high mobility group AT-hook 1 -0.0560121
IFITM1 interferon induced transmembrane protein 1 -0.055835
HLA-B major histocompatibility complex, class I, B -0.0555792
TMSB4X thymosin beta 4, X-linked -0.0555407
WSB1 WD repeat and SOCS box containing 1 -0.0553521
SAMD4A sterile alpha motif domain containing 4A -0.0546743
KRT7 keratin 7, type II -0.0546677
TM4SF1 transmembrane 4 L six family member 1 -0.054393
PTMA prothymosin, alpha -0.0536938
CCND1 cyclin D1 -0.052251
RPL8 ribosomal protein L8 -0.0488451
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0480594
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0468526
LOC112694756 uncharaterized LOC112694756 -0.0462325
MDK midkine (neurite growth-promoting factor 2) -0.0454804
TPM4 tropomyosin 4 -0.0454348
HLA-A major histocompatibility complex, class I, A -0.0446243
CD2AP CD2-associated protein -0.0438435
MX2 MX dynamin-like GTPase 2 -0.0437766
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0435783
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0434957
ZBTB20 zinc finger and BTB domain containing 20 -0.0434934
S100A9 S100 calcium binding protein A9 -0.0416202
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0414613
BASP1 brain abundant, membrane attached signal protein 1 -0.0413586
LY6E lymphocyte antigen 6 complex, locus E -0.0413369
LMNA lamin A/C -0.0401565
POTEF POTE ankyrin domain family, member F -0.0392996
KRT19 keratin 19, type I -0.0392002
VCL vinculin -0.03859
RRBP1 ribosome binding protein 1 -0.0384721
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0384668
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0382557
DSG2 desmoglein 2 -0.0378188
AHNAK AHNAK nucleoprotein -0.0374132
H1-0 H1.0 linker histone -0.037336
RNF213 ring finger protein 213 -0.0371219
HSPB1 heat shock 27kDa protein 1 -0.0369971
GNAS GNAS complex locus -0.0366382
RPS19 ribosomal protein S19 -0.0359576
C15ORF48 chromosome 15 open reading frame 48 -0.0354416
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0353394
TPI1 triosephosphate isomerase 1 -0.0352356
PLSCR1 phospholipid scramblase 1 -0.0352132
ETV6 ets variant 6 -0.0345615
RPS21 ribosomal protein S21 -0.0345084
KRT8 keratin 8, type II -0.0336372
RPS24 ribosomal protein S24 -0.0334235
MX1 MX dynamin-like GTPase 1 -0.0327134
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0326797
MAML2 mastermind-like 2 (Drosophila) -0.0326726
RPS23 ribosomal protein S23 -0.0323242
RPL30 ribosomal protein L30 -0.0322271
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0317791
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0314606
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0313188
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0313167
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0311475
CTSB cathepsin B -0.0309693
MYO1E myosin IE -0.0309491
GOLGB1 golgin B1 -0.0307148
ATXN1 ataxin 1 -0.0306579
RAI14 retinoic acid induced 14 -0.0305398
RPLP2 ribosomal protein, large, P2 -0.0303835
EIF1 eukaryotic translation initiation factor 1 -0.0299716
RPL37 ribosomal protein L37 -0.0299485
IFIH1 interferon induced with helicase C domain 1 -0.0298935
RPL32 ribosomal protein L32 -0.029258
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0292261
SP100 SP100 nuclear antigen -0.029081
F11R F11 receptor -0.0290044
RPS13 ribosomal protein S13 -0.028996