Acetazolamide_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetazolamide perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetazolamide_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.0532777
ERRFI1 ERBB receptor feedback inhibitor 1 0.0436833
OGA O-GlcNAcase 0.0423421
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0413044
NAMPT nicotinamide phosphoribosyltransferase 0.0390481
FN1 fibronectin 1 0.0344127
BZW1 basic leucine zipper and W2 domains 1 0.0305598
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0300678
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0298741
PDGFA platelet-derived growth factor alpha polypeptide 0.0298662
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0294876
KMT2C lysine (K)-specific methyltransferase 2C 0.029209
AGFG1 ArfGAP with FG repeats 1 0.029027
FAM13A family with sequence similarity 13, member A 0.02892
MYOF myoferlin 0.0268696
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0261563
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.025921
SPAG9 sperm associated antigen 9 0.0255051
ESYT2 extended synaptotagmin-like protein 2 0.0254982
NUP58 nucleoporin 58 0.0254098
COPA coatomer protein complex, subunit alpha 0.0239542
FNDC3A fibronectin type III domain containing 3A 0.0235931
SAMD4A sterile alpha motif domain containing 4A 0.0235054
ATP13A3 ATPase type 13A3 0.0235008
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0229299
CHD1 chromodomain helicase DNA binding protein 1 0.0228217
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0223264
RTN4 reticulon 4 0.0221056
KMT2E lysine (K)-specific methyltransferase 2E 0.021627
SUCO SUN domain containing ossification factor 0.0210731
HELZ helicase with zinc finger 0.0209227
UBA6 ubiquitin-like modifier activating enzyme 6 0.0208459
GOLGA4 golgin A4 0.0205633
KDM6A lysine (K)-specific demethylase 6A 0.0204578
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0202053
TRIO trio Rho guanine nucleotide exchange factor 0.0200551
CD109 CD109 molecule 0.0199704
CXCL8 chemokine (C-X-C motif) ligand 8 0.0197015
CDC73 cell division cycle 73 0.0196028
PM20D1 peptidase M20 domain containing 1 0.0193617
DDIT4 DNA-damage-inducible transcript 4 0.0192886
RNF145 ring finger protein 145 0.0185471
USP9X ubiquitin specific peptidase 9, X-linked 0.0177018
IGFBP3 insulin-like growth factor binding protein 3 0.0173796
WDR45B WD repeat domain 45B 0.0172569
MSN moesin 0.0171585
PICALM phosphatidylinositol binding clathrin assembly protein 0.016535
ZEB2 zinc finger E-box binding homeobox 2 0.0162685
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0162632
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0159334
ANXA5 annexin A5 0.0152368
TGFBR1 transforming growth factor, beta receptor 1 0.0152309
IL1RAP interleukin 1 receptor accessory protein 0.0149821
HILPDA hypoxia inducible lipid droplet-associated 0.0149724
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0148638
LIMCH1 LIM and calponin homology domains 1 0.0147701
AVL9 AVL9 homolog (S. cerevisiase) 0.0144498
ITPRID2 ITPR interacting domain containing 2 0.0144175
EZR ezrin 0.0141373
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0140203
MXI1 MAX interactor 1, dimerization protein 0.0140187
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0139532
ZFC3H1 zinc finger, C3H1-type containing 0.0134612
BIRC6 baculoviral IAP repeat containing 6 0.013329
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0132945
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0132712
USP37 ubiquitin specific peptidase 37 0.0131988
NGLY1 N-glycanase 1 0.0130561
NBAS neuroblastoma amplified sequence 0.0129869
NEK7 NIMA-related kinase 7 0.0129113
ECT2 epithelial cell transforming 2 0.0126301
WAC WW domain containing adaptor with coiled-coil 0.0124884
ADAM9 ADAM metallopeptidase domain 9 0.0123777
CNOT2 CCR4-NOT transcription complex, subunit 2 0.012325
GARS1 glycyl-tRNA synthetase 1 0.0121566
NCKAP1 NCK-associated protein 1 0.0121335
ZC3H11A zinc finger CCCH-type containing 11A 0.0121269
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0120808
AFDN afadin, adherens junction formation factor 0.0120703
ZNF292 zinc finger protein 292 0.0120409
TRA2A transformer 2 alpha homolog (Drosophila) 0.0120034
TENT5A terminal nucleotidyltransferase 5A 0.0119769
BIRC2 baculoviral IAP repeat containing 2 0.0119037
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0117377
CCNL1 cyclin L1 0.0116376
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0115458
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0113776
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0112928
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0112189
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0111982
KDM3A lysine (K)-specific demethylase 3A 0.0110429
CHD1L chromodomain helicase DNA binding protein 1-like 0.0109771
STC2 stanniocalcin 2 0.0109557
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0109354
PTPRJ protein tyrosine phosphatase, receptor type, J 0.010859
TPD52 tumor protein D52 0.0106218
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0105842
FLNB filamin B, beta 0.0105209
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0105183
CRY1 cryptochrome circadian clock 1 0.010458

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.24115
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.183141
VIM vimentin -0.141692
TMSB10 thymosin beta 10 -0.136618
PDE10A phosphodiesterase 10A -0.105734
TPT1 tumor protein, translationally-controlled 1 -0.104199
PTMA prothymosin, alpha -0.0983129
FTL ferritin, light polypeptide -0.0970467
RPLP1 ribosomal protein, large, P1 -0.094696
NALF1 NALCN channel auxiliary factor 1 -0.0894366
COL5A2 collagen, type V, alpha 2 -0.0890482
PSD3 pleckstrin and Sec7 domain containing 3 -0.0872551
RPS6 ribosomal protein S6 -0.086135
RPS8 ribosomal protein S8 -0.0794405
RPL31 ribosomal protein L31 -0.0789427
ASPH aspartate beta-hydroxylase -0.0776453
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.076371
RPS24 ribosomal protein S24 -0.0762816
RPS27A ribosomal protein S27a -0.0758368
RPL35A ribosomal protein L35a -0.0742441
RPL37A ribosomal protein L37a -0.0740741
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.072852
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0642094
RPL23 ribosomal protein L23 -0.0632447
RPS23 ribosomal protein S23 -0.0630601
SMYD3 SET and MYND domain containing 3 -0.0630277
RPS12 ribosomal protein S12 -0.0622267
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0605243
RPL12 ribosomal protein L12 -0.0604524
RPL19 ribosomal protein L19 -0.0586036
RPS19 ribosomal protein S19 -0.0582583
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0582316
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0579717
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0577452
RPL26 ribosomal protein L26 -0.057612
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0572264
RPL9 ribosomal protein L9 -0.0568461
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0541108
TXNRD1 thioredoxin reductase 1 -0.053267
CDH13 cadherin 13 -0.0517447
MAML3 mastermind-like 3 (Drosophila) -0.0496572
RPLP2 ribosomal protein, large, P2 -0.048094
PRKN parkin RBR E3 ubiquitin protein ligase -0.0480695
RPS29 ribosomal protein S29 -0.046913
RPS3 ribosomal protein S3 -0.0465376
RPL34 ribosomal protein L34 -0.046377
RPS27 ribosomal protein S27 -0.0455645
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0455135
RPL36A ribosomal protein L36a -0.0450583
RPS4X ribosomal protein S4, X-linked -0.0446925
RPL37 ribosomal protein L37 -0.0446268
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0442709
ACTG1 actin gamma 1 -0.0435537
S100A10 S100 calcium binding protein A10 -0.0426308
UBC ubiquitin C -0.0423852
COL4A5 collagen, type IV, alpha 5 -0.0422892
RPLP0 ribosomal protein, large, P0 -0.0417165
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0405473
RPL36 ribosomal protein L36 -0.0399896
RPS14 ribosomal protein S14 -0.0394867
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0394405
RPS25 ribosomal protein S25 -0.0393778
RPL38 ribosomal protein L38 -0.0392676
RPL7A ribosomal protein L7a -0.0386648
ENO1 enolase 1, (alpha) -0.0383113
RPS16 ribosomal protein S16 -0.0381281
RPS13 ribosomal protein S13 -0.0378974
S100A6 S100 calcium binding protein A6 -0.0377741
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0372186
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0367799
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0366223
EEF2 eukaryotic translation elongation factor 2 -0.0365949
HLA-B major histocompatibility complex, class I, B -0.0362544
RPS17 ribosomal protein S17 -0.0360112
RPL11 ribosomal protein L11 -0.0358529
RPS21 ribosomal protein S21 -0.0355578
RPL5 ribosomal protein L5 -0.0345288
GNAS GNAS complex locus -0.0345211
RPL13A ribosomal protein L13a -0.0340819
RACK1 receptor for activated C kinase 1 -0.0332665
LDHA lactate dehydrogenase A -0.0322125
B2M beta-2-microglobulin -0.0321045
RPL35 ribosomal protein L35 -0.0311527
LOC112694756 uncharaterized LOC112694756 -0.0305714
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0300142
NAP1L1 nucleosome assembly protein 1-like 1 -0.0298248
PKM pyruvate kinase, muscle -0.0295364
PTPRM protein tyrosine phosphatase, receptor type, M -0.0290295
RPL28 ribosomal protein L28 -0.0284951
ANTXR1 anthrax toxin receptor 1 -0.0284413
RPS11 ribosomal protein S11 -0.0280967
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0279826
TBXT T-box transcription factor T -0.027463
RAD51B RAD51 paralog B -0.0273708
HLA-A major histocompatibility complex, class I, A -0.0272264
CADM2 cell adhesion molecule 2 -0.0271671
RPS5 ribosomal protein S5 -0.0266599
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0263884
RPL27 ribosomal protein L27 -0.0263857
SRGN serglycin -0.0263164