Acetazolamide_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetazolamide perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetazolamide_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.113483
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.108285
PTMA prothymosin, alpha 0.0969834
MATR3 matrin 3 0.0854445
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.074015
RNF145 ring finger protein 145 0.072962
HILPDA hypoxia inducible lipid droplet-associated 0.0690855
RPS6 ribosomal protein S6 0.0673554
WAC WW domain containing adaptor with coiled-coil 0.0671874
RSRC2 arginine/serine-rich coiled-coil 2 0.0643245
NAP1L1 nucleosome assembly protein 1-like 1 0.0625639
PNISR PNN-interacting serine/arginine-rich protein 0.0596771
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0576644
RPS3 ribosomal protein S3 0.0572073
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0571218
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0571057
GOLGA2 golgin A2 0.0556011
RB1CC1 RB1-inducible coiled-coil 1 0.0535386
CHD1 chromodomain helicase DNA binding protein 1 0.0531828
EIF1 eukaryotic translation initiation factor 1 0.0517371
DIAPH3 diaphanous-related formin 3 0.0509698
RPS12 ribosomal protein S12 0.0500933
RPL12 ribosomal protein L12 0.0499123
RPL26 ribosomal protein L26 0.0490323
DSCAM Down syndrome cell adhesion molecule 0.0473207
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0464615
RPLP1 ribosomal protein, large, P1 0.044081
OLA1 Obg-like ATPase 1 0.0439269
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0435562
RPL23 ribosomal protein L23 0.0429466
VIM vimentin 0.0427417
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0422484
NUP58 nucleoporin 58 0.0421818
RPS14 ribosomal protein S14 0.040721
NAMPT nicotinamide phosphoribosyltransferase 0.0405479
CANX calnexin 0.0400816
RPL36 ribosomal protein L36 0.0382891
COPA coatomer protein complex, subunit alpha 0.0382629
PNN pinin, desmosome associated protein 0.0378713
ARRDC3 arrestin domain containing 3 0.0372499
RPS13 ribosomal protein S13 0.0366736
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0359611
DEK DEK proto-oncogene 0.0358308
RPL9 ribosomal protein L9 0.0353098
B2M beta-2-microglobulin 0.0352757
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0351262
MARCHF6 membrane associated ring-CH-type finger 6 0.0350487
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0348259
SET SET nuclear proto-oncogene 0.034639
RACK1 receptor for activated C kinase 1 0.0344766
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.034238
MIS18BP1 MIS18 binding protein 1 0.0337384
TENT2 terminal nucleotidyltransferase 2 0.0336445
BIRC2 baculoviral IAP repeat containing 2 0.0333789
RBM25 RNA binding motif protein 25 0.0331722
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0327385
RPL32 ribosomal protein L32 0.0327343
SEC23A Sec23 homolog A (S. cerevisiae) 0.0327268
TFG TRK-fused gene 0.0327037
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0323729
RPS8 ribosomal protein S8 0.0323623
WDR43 WD repeat domain 43 0.0322875
OGA O-GlcNAcase 0.0320934
RPS17 ribosomal protein S17 0.0319146
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0317545
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0311146
AKAP9 A kinase (PRKA) anchor protein 9 0.031072
PIBF1 progesterone immunomodulatory binding factor 1 0.0310149
TMEM41B transmembrane protein 41B 0.0310095
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.030958
HMGB2 high mobility group box 2 0.0306031
ATP13A3 ATPase type 13A3 0.0304034
RAB8B RAB8B, member RAS oncogene family 0.0302089
CDK19 cyclin-dependent kinase 19 0.0301371
PRPF4B pre-mRNA processing factor 4B 0.0300514
TBK1 TANK-binding kinase 1 0.0300428
S100A9 S100 calcium binding protein A9 0.0299429
RBM27 RNA binding motif protein 27 0.0297313
TOP1 topoisomerase (DNA) I 0.0294944
PEAK1 pseudopodium-enriched atypical kinase 1 0.0294588
KIF20B kinesin family member 20B 0.0294015
TAOK3 TAO kinase 3 0.0293708
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0292267
ECPAS Ecm29 proteasome adaptor and scaffold 0.0291173
CLINT1 clathrin interactor 1 0.0290929
RICTOR RPTOR independent companion of MTOR, complex 2 0.0290411
GOLGA4 golgin A4 0.0290118
GARS1 glycyl-tRNA synthetase 1 0.0290026
HELZ helicase with zinc finger 0.0289139
EIF5B eukaryotic translation initiation factor 5B 0.0287988
RPS15 ribosomal protein S15 0.0287798
CKAP5 cytoskeleton associated protein 5 0.0287282
IWS1 IWS1 homolog (S. cerevisiae) 0.0286819
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0286464
SEPTIN7 septin 7 0.0286236
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0285481
GIGYF2 GRB10 interacting GYF protein 2 0.0284129
NPTN neuroplastin 0.0283916
YTHDC1 YTH domain containing 1 0.0283015
UGCG UDP-glucose ceramide glucosyltransferase 0.0278621

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.120421
INTS6 integrator complex subunit 6 -0.0946141
DST dystonin -0.0924097
FNDC3B fibronectin type III domain containing 3B -0.0823419
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0804855
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.079927
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0753452
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0744143
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0738566
RIGI RNA sensor RIG-I -0.0683142
ATM ATM serine/threonine kinase -0.065329
GPC6 glypican 6 -0.0620116
THSD4 thrombospondin, type I, domain containing 4 -0.0593767
SLC38A2 solute carrier family 38, member 2 -0.0588638
PRSS23 protease, serine, 23 -0.0569015
SVIL supervillin -0.056178
PRKCA protein kinase C, alpha -0.0531662
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0531424
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0530304
MACF1 microtubule-actin crosslinking factor 1 -0.0521977
EGR1 early growth response 1 -0.0509542
AHNAK AHNAK nucleoprotein -0.0499411
AEBP2 AE binding protein 2 -0.0472311
FBXL7 F-box and leucine-rich repeat protein 7 -0.0469088
EXOC4 exocyst complex component 4 -0.0465871
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0460144
FMN1 formin 1 -0.0459227
ZBTB20 zinc finger and BTB domain containing 20 -0.0451145
EXT1 exostosin glycosyltransferase 1 -0.0432924
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0427766
TBC1D5 TBC1 domain family, member 5 -0.0425038
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0424747
RAD51B RAD51 paralog B -0.0421346
RAI14 retinoic acid induced 14 -0.0419695
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0413731
TNRC18 trinucleotide repeat containing 18 -0.0411711
VCL vinculin -0.0411061
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0408435
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0407974
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0401379
JARID2 jumonji, AT rich interactive domain 2 -0.0401048
BICD1 bicaudal D homolog 1 (Drosophila) -0.0397649
FMNL2 formin-like 2 -0.0386754
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0378639
PRH1 proline-rich protein HaeIII subfamily 1 -0.0378361
ATXN1 ataxin 1 -0.0377245
FLNB filamin B, beta -0.0375113
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.03731
NABP1 nucleic acid binding protein 1 -0.0372837
PTPRK protein tyrosine phosphatase, receptor type, K -0.0369379
NAV2 neuron navigator 2 -0.0364269
PRELID2 PRELI domain containing 2 -0.0363164
ANXA2 annexin A2 -0.0358892
PRKCE protein kinase C, epsilon -0.0351834
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0351054
COL5A1 collagen, type V, alpha 1 -0.0350451
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0350264
NPAS2 neuronal PAS domain protein 2 -0.0349397
RUNX1 runt-related transcription factor 1 -0.0348589
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0346359
PRR16 proline rich 16 -0.0339485
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0338429
ABR active BCR-related -0.0337611
LPP LIM domain containing preferred translocation partner in lipoma -0.0335327
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0332055
ATG7 autophagy related 7 -0.0332051
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0331173
CEMIP2 cell migration inducing hyaluronidase 2 -0.0326121
MCTP1 multiple C2 domains, transmembrane 1 -0.0324888
FER fer (fps/fes related) tyrosine kinase -0.0323854
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0322607
PCNX4 pecanex 4 -0.0321503
LMO7 LIM domain 7 -0.0321279
GPC5 glypican 5 -0.0319962
ANGPTL4 angiopoietin-like 4 -0.0319579
IGF1R insulin-like growth factor 1 receptor -0.031894
DOCK1 dedicator of cytokinesis 1 -0.0318639
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0318375
TRIP12 thyroid hormone receptor interactor 12 -0.0317317
NAV3 neuron navigator 3 -0.0317315
SKIL SKI-like proto-oncogene -0.0313859
FOXO3 forkhead box O3 -0.0313055
PKM pyruvate kinase, muscle -0.0312793
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0311426
TAS2R14 taste receptor, type 2, member 14 -0.0311035
NLK nemo-like kinase -0.031085
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0310658
CYTH1 cytohesin 1 -0.0304801
PODXL podocalyxin-like -0.0303182
DPYD dihydropyrimidine dehydrogenase -0.0299403
DENND5B DENN/MADD domain containing 5B -0.0298267
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0297556
BABAM2 BRISC and BRCA1 A complex member 2 -0.0295455
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0294899
EGFR epidermal growth factor receptor -0.0293396
LAMA5 laminin, alpha 5 -0.0293301
IL6ST interleukin 6 signal transducer -0.0290114
SMYD3 SET and MYND domain containing 3 -0.0289962
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0284546
BCAR3 breast cancer anti-estrogen resistance 3 -0.0283911