Acetohexamide_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0695004
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0606585
TRIO trio Rho guanine nucleotide exchange factor 0.0599823
LIMCH1 LIM and calponin homology domains 1 0.053858
LINGO2 leucine rich repeat and Ig domain containing 2 0.0537249
MAP1B microtubule-associated protein 1B 0.0529653
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0482259
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0480469
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0474719
PDE4D phosphodiesterase 4D, cAMP-specific 0.0447405
NCAM2 neural cell adhesion molecule 2 0.0443101
ZFAND3 zinc finger, AN1-type domain 3 0.0438402
PLAT plasminogen activator, tissue 0.0424569
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0412795
MACF1 microtubule-actin crosslinking factor 1 0.0376584
ITPRID2 ITPR interacting domain containing 2 0.0374753
ATXN1 ataxin 1 0.0357167
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0344327
SLIT2 slit homolog 2 (Drosophila) 0.0343954
NALF1 NALCN channel auxiliary factor 1 0.0343129
ZBTB20 zinc finger and BTB domain containing 20 0.0342729
DPH6 diphthamine biosynthesis 6 0.0329514
RPTOR regulatory associated protein of MTOR, complex 1 0.0320086
BPTF bromodomain PHD finger transcription factor 0.0318403
ATRNL1 attractin-like 1 0.0314768
PTPRK protein tyrosine phosphatase, receptor type, K 0.0313198
HMGA2 high mobility group AT-hook 2 0.0307378
LPIN1 lipin 1 0.0302054
JMJD1C jumonji domain containing 1C 0.0299149
RUNX1 runt-related transcription factor 1 0.0297526
STC1 stanniocalcin 1 0.029079
CEMIP cell migration inducing protein, hyaluronan binding 0.0282447
EXT1 exostosin glycosyltransferase 1 0.028224
FLNB filamin B, beta 0.0281676
TRPS1 trichorhinophalangeal syndrome I 0.0280572
TTC3 tetratricopeptide repeat domain 3 0.0277819
DST dystonin 0.0275471
CD36 CD36 molecule (thrombospondin receptor) 0.0274815
ANTXR1 anthrax toxin receptor 1 0.0271055
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0269652
NEK1 NIMA-related kinase 1 0.0266408
SYT1 synaptotagmin I 0.0262874
AEBP2 AE binding protein 2 0.0261609
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0260965
FRMD4A FERM domain containing 4A 0.0255348
ZNF804A zinc finger protein 804A 0.0253229
SMAD3 SMAD family member 3 0.0253078
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0253073
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0252995
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.024967
NRIP1 nuclear receptor interacting protein 1 0.0240486
EXOC4 exocyst complex component 4 0.0238959
PTPRE protein tyrosine phosphatase, receptor type, E 0.0238898
SEPTIN9 septin 9 0.0233786
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0233713
CARD16 caspase recruitment domain family, member 16 0.0229149
COL4A5 collagen, type IV, alpha 5 0.0228909
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0228178
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0226479
CSNK1A1 casein kinase 1, alpha 1 0.0226206
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0222952
PEAK1 pseudopodium-enriched atypical kinase 1 0.0220475
BIRC6 baculoviral IAP repeat containing 6 0.022038
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0220174
ANO6 anoctamin 6 0.0217968
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0217592
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0217186
PTEN phosphatase and tensin homolog 0.0217004
FNDC3B fibronectin type III domain containing 3B 0.0216487
TAS2R14 taste receptor, type 2, member 14 0.0214871
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0213891
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0210318
MED13L mediator complex subunit 13-like 0.0209889
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0209854
PICALM phosphatidylinositol binding clathrin assembly protein 0.0208054
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.0207243
UNC5C unc-5 homolog C (C. elegans) 0.0205406
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0204943
DGKH diacylglycerol kinase, eta 0.0203891
NBAS neuroblastoma amplified sequence 0.0201801
CADM2 cell adhesion molecule 2 0.0199717
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0199285
GPC5 glypican 5 0.0199236
BCAS3 breast carcinoma amplified sequence 3 0.0198918
ITGA1 integrin, alpha 1 0.0198604
COL4A6 collagen, type IV, alpha 6 0.0197792
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0195996
MCL1 myeloid cell leukemia 1 0.0195675
NME7 NME/NM23 family member 7 0.019548
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0191509
SOS1 son of sevenless homolog 1 (Drosophila) 0.0191154
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0191121
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0190213
TENM3 teneurin transmembrane protein 3 0.0189165
CCNY cyclin Y 0.0188989
TOX thymocyte selection-associated high mobility group box 0.0188525
ZNF521 zinc finger protein 521 0.0186517
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0185269
ZNF638 zinc finger protein 638 0.0182625
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0182312

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.159288
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148905
PTMA prothymosin, alpha -0.0807782
VCL vinculin -0.0726751
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0640618
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0559869
RPL23 ribosomal protein L23 -0.0536273
RPL38 ribosomal protein L38 -0.0495928
RPL34 ribosomal protein L34 -0.0488274
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.047686
TPT1 tumor protein, translationally-controlled 1 -0.0476126
EGR1 early growth response 1 -0.0455862
RPL35A ribosomal protein L35a -0.0439535
VIM vimentin -0.0422621
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0390351
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0369972
RPS6 ribosomal protein S6 -0.0364256
RPL19 ribosomal protein L19 -0.0353797
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0352563
NAP1L1 nucleosome assembly protein 1-like 1 -0.0342168
COL1A1 collagen, type I, alpha 1 -0.0337202
RPS24 ribosomal protein S24 -0.0334436
LSAMP limbic system-associated membrane protein -0.0323688
COL3A1 collagen, type III, alpha 1 -0.0312304
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0306827
RPLP1 ribosomal protein, large, P1 -0.0306064
RPL26 ribosomal protein L26 -0.0305027
WDR45B WD repeat domain 45B -0.0298959
DSCAM Down syndrome cell adhesion molecule -0.0298434
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0282945
RSL1D1 ribosomal L1 domain containing 1 -0.0282827
RPS12 ribosomal protein S12 -0.0281973
IER3 immediate early response 3 -0.0279421
TPM4 tropomyosin 4 -0.0274992
RPS19 ribosomal protein S19 -0.0274415
RPL36A ribosomal protein L36a -0.0272463
LMNA lamin A/C -0.0267707
RPLP0 ribosomal protein, large, P0 -0.0263064
HILPDA hypoxia inducible lipid droplet-associated -0.0261845
RPL37A ribosomal protein L37a -0.0258475
KLF6 Kruppel-like factor 6 -0.0257519
RPL36 ribosomal protein L36 -0.0256389
TRIB2 tribbles pseudokinase 2 -0.0256178
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0254176
FNDC3A fibronectin type III domain containing 3A -0.025019
STK38L serine/threonine kinase 38 like -0.0248225
RPL32 ribosomal protein L32 -0.0247102
RPS25 ribosomal protein S25 -0.0244859
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0242611
ACTG1 actin gamma 1 -0.0240813
RPS8 ribosomal protein S8 -0.0237569
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0236787
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0229114
CCDC47 coiled-coil domain containing 47 -0.022778
RPL37 ribosomal protein L37 -0.0226817
RPS27 ribosomal protein S27 -0.0226676
TPR translocated promoter region, nuclear basket protein -0.0226437
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0221036
RPS2 ribosomal protein S2 -0.022027
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0214919
FNBP1 formin binding protein 1 -0.0212189
PTPRD protein tyrosine phosphatase, receptor type, D -0.020902
FAM13A family with sequence similarity 13, member A -0.0208364
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.020692
RPS27A ribosomal protein S27a -0.0205745
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0203098
LOC112694756 uncharaterized LOC112694756 -0.020225
RPL27 ribosomal protein L27 -0.0199589
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0196352
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0195378
S100A6 S100 calcium binding protein A6 -0.0191294
GATA3 GATA binding protein 3 -0.0189162
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0184217
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0182913
MEIS2 Meis homeobox 2 -0.0182697
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0179196
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0177877
KDM4C lysine (K)-specific demethylase 4C -0.01741
RPL35 ribosomal protein L35 -0.0172339
S100A9 S100 calcium binding protein A9 -0.0171454
RACK1 receptor for activated C kinase 1 -0.0171129
IFI6 interferon, alpha-inducible protein 6 -0.0170522
TPM1 tropomyosin 1 (alpha) -0.0169243
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -0.0168131
FKBP10 FK506 binding protein 10, 65 kDa -0.0166481
NAMPT nicotinamide phosphoribosyltransferase -0.0166011
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0165686
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.0165379
NKD1 naked cuticle homolog 1 (Drosophila) -0.0161686
RPL7A ribosomal protein L7a -0.0160459
RNF150 ring finger protein 150 -0.0159852
CANX calnexin -0.0156947
KDM4B lysine (K)-specific demethylase 4B -0.0156737
TLE4 transducin-like enhancer of split 4 -0.015493
AKAP12 A kinase (PRKA) anchor protein 12 -0.0153454
SSH2 slingshot protein phosphatase 2 -0.0153431
GSE1 Gse1 coiled-coil protein -0.0152741
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -0.0152708
GLCCI1 glucocorticoid induced 1 -0.0152522
RPS29 ribosomal protein S29 -0.01523