Acetohexamide_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.175501
ARHGAP26 Rho GTPase activating protein 26 0.106039
EPSTI1 epithelial stromal interaction 1 (breast) 0.0997321
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0804757
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0764383
BTBD9 BTB (POZ) domain containing 9 0.0742744
GCLC glutamate-cysteine ligase, catalytic subunit 0.0724328
STAT1 signal transducer and activator of transcription 1, 91kDa 0.069236
EXT1 exostosin glycosyltransferase 1 0.0692154
XAF1 XIAP associated factor 1 0.0688294
MACC1 metastasis associated in colon cancer 1 0.0642482
RUNX1 runt-related transcription factor 1 0.0636629
H1-0 H1.0 linker histone 0.0618856
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0613031
SPATA13 spermatogenesis associated 13 0.0602653
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0587687
ATP10B ATPase, class V, type 10B 0.0567752
MBNL2 muscleblind-like splicing regulator 2 0.0560901
MYO1E myosin IE 0.0541897
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0540358
MSI2 musashi RNA-binding protein 2 0.0477342
TRIO trio Rho guanine nucleotide exchange factor 0.0476559
GMDS GDP-mannose 4,6-dehydratase 0.0470717
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0461565
RNF213 ring finger protein 213 0.0447537
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0446452
ZBTB20 zinc finger and BTB domain containing 20 0.0440384
LPP LIM domain containing preferred translocation partner in lipoma 0.0434345
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0419557
ITGA6 integrin, alpha 6 0.0419442
ABLIM1 actin binding LIM protein 1 0.0417535
MECOM MDS1 and EVI1 complex locus 0.0404619
MEIS2 Meis homeobox 2 0.0403299
ETV6 ets variant 6 0.0394521
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0387403
PRKCA protein kinase C, alpha 0.0381196
ANXA2 annexin A2 0.0379953
MUC13 mucin 13, cell surface associated 0.037901
PRSS3 protease, serine, 3 0.0367612
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0367558
FMN1 formin 1 0.0367465
FAT1 FAT atypical cadherin 1 0.0360333
ABHD2 abhydrolase domain containing 2 0.0359634
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0357754
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0349005
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0348503
DSPP dentin sialophosphoprotein 0.0341928
FNDC3B fibronectin type III domain containing 3B 0.0341099
TSHZ2 teashirt zinc finger homeobox 2 0.0338274
LURAP1L leucine rich adaptor protein 1-like 0.0335264
RNF43 ring finger protein 43 0.0333708
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0330826
NCKAP5 NCK-associated protein 5 0.0328617
MACF1 microtubule-actin crosslinking factor 1 0.0327508
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0322553
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0321989
IFNGR1 interferon gamma receptor 1 0.0319246
ERRFI1 ERBB receptor feedback inhibitor 1 0.0317538
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0315832
EPS8 epidermal growth factor receptor pathway substrate 8 0.0315755
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0313045
FRMD5 FERM domain containing 5 0.0312321
SDCBP2 syndecan binding protein (syntenin) 2 0.0306926
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0305085
RIGI RNA sensor RIG-I 0.0298786
FNDC3A fibronectin type III domain containing 3A 0.0298584
CD2AP CD2-associated protein 0.0298373
PRELID2 PRELI domain containing 2 0.0297676
CATSPERB catsper channel auxiliary subunit beta 0.0296378
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0293912
ARHGAP5 Rho GTPase activating protein 5 0.0293097
SQSTM1 sequestosome 1 0.0291534
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0291306
AREG amphiregulin 0.0289519
RBM39 RNA binding motif protein 39 0.0289479
ANXA3 annexin A3 0.0289134
SMAD3 SMAD family member 3 0.0288456
KLF5 Kruppel-like factor 5 (intestinal) 0.0287981
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.028175
SAMD9 sterile alpha motif domain containing 9 0.0278436
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0277733
PHF3 PHD finger protein 3 0.0277231
USP54 ubiquitin specific peptidase 54 0.027677
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0275583
RSAD2 radical S-adenosyl methionine domain containing 2 0.0275529
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0272997
NEBL nebulette 0.0272783
SORBS1 sorbin and SH3 domain containing 1 0.026936
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 0.0268325
RABGAP1L RAB GTPase activating protein 1-like 0.0265592
TMEM123 transmembrane protein 123 0.0263019
EHF ets homologous factor 0.0257794
CD164 CD164 molecule, sialomucin 0.025716
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0256465
ZMYND8 zinc finger, MYND-type containing 8 0.0255943
NCOA7 nuclear receptor coactivator 7 0.0255124
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0253526
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.025308
ANKRD10 ankyrin repeat domain 10 0.0251643
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0251549

decreased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 -0.101242
B2M beta-2-microglobulin -0.0846894
TPT1 tumor protein, translationally-controlled 1 -0.0805767
LYZ lysozyme -0.0703982
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0699628
TXNIP thioredoxin interacting protein -0.0672381
PTMA prothymosin, alpha -0.0646243
PKM pyruvate kinase, muscle -0.0624079
RPL35A ribosomal protein L35a -0.0585411
RPS6 ribosomal protein S6 -0.0575364
IFI27 interferon, alpha-inducible protein 27 -0.0506856
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0496722
P4HB prolyl 4-hydroxylase, beta polypeptide -0.049032
EGR1 early growth response 1 -0.0473035
TMSB10 thymosin beta 10 -0.0462554
RPL23 ribosomal protein L23 -0.0408499
INTS6 integrator complex subunit 6 -0.0405157
HLA-B major histocompatibility complex, class I, B -0.034585
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0333722
FTL ferritin, light polypeptide -0.0329261
PDIA3 protein disulfide isomerase family A, member 3 -0.0324787
TNS4 tensin 4 -0.0314282
RPS8 ribosomal protein S8 -0.0305084
MPHOSPH8 M-phase phosphoprotein 8 -0.0292072
LOC102724023 ES1 protein homolog, mitochondrial -0.0289681
RPL34 ribosomal protein L34 -0.0286025
RPS27 ribosomal protein S27 -0.0279587
HLA-A major histocompatibility complex, class I, A -0.0272549
RPS19 ribosomal protein S19 -0.0266857
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0266452
MCL1 myeloid cell leukemia 1 -0.0260353
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0247646
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0245352
VEGFA vascular endothelial growth factor A -0.0238595
RPL9 ribosomal protein L9 -0.0238011
TAOK3 TAO kinase 3 -0.0234681
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0234562
RPL21 ribosomal protein L21 -0.0233719
S100A9 S100 calcium binding protein A9 -0.0232873
RPLP1 ribosomal protein, large, P1 -0.0229912
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0228
RPL11 ribosomal protein L11 -0.0227926
RPS11 ribosomal protein S11 -0.0225388
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0224042
IFITM3 interferon induced transmembrane protein 3 -0.0222877
RPS23 ribosomal protein S23 -0.0222449
RPS13 ribosomal protein S13 -0.0222078
PRRC2C proline-rich coiled-coil 2C -0.0220713
RPL12 ribosomal protein L12 -0.0219744
UBXN4 UBX domain protein 4 -0.0217511
RPL31 ribosomal protein L31 -0.0215949
RPL35 ribosomal protein L35 -0.0214304
RPS12 ribosomal protein S12 -0.021202
IFI6 interferon, alpha-inducible protein 6 -0.0207183
POTEF POTE ankyrin domain family, member F -0.0205134
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0202475
FTH1 ferritin, heavy polypeptide 1 -0.0202277
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.020131
KTN1 kinectin 1 (kinesin receptor) -0.020072
SRRM2 serine/arginine repetitive matrix 2 -0.0197643
DSTN destrin (actin depolymerizing factor) -0.0196591
EIF1 eukaryotic translation initiation factor 1 -0.0194525
ATF4 activating transcription factor 4 -0.019221
RPL8 ribosomal protein L8 -0.0191386
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0188681
NBR1 neighbor of BRCA1 gene 1 -0.0188325
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0185564
RPL37A ribosomal protein L37a -0.0185292
CD46 CD46 molecule, complement regulatory protein -0.01852
RPS29 ribosomal protein S29 -0.0184925
USP8 ubiquitin specific peptidase 8 -0.0184816
MCTP1 multiple C2 domains, transmembrane 1 -0.0184524
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0183796
DSCAM Down syndrome cell adhesion molecule -0.0181195
RPLP0 ribosomal protein, large, P0 -0.0179248
ZNF148 zinc finger protein 148 -0.0179221
ACTG1 actin gamma 1 -0.017806
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0176062
RTN4 reticulon 4 -0.0175617
OARD1 O-acyl-ADP-ribose deacylase 1 -0.0175304
CST3 cystatin C -0.0174564
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0173754
POMP proteasome maturation protein -0.0172239
RPS14 ribosomal protein S14 -0.0171639
CCNL1 cyclin L1 -0.0171601
BABAM2 BRISC and BRCA1 A complex member 2 -0.0171222
POU2F2 POU class 2 homeobox 2 -0.0169018
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0167646
SETX senataxin -0.0167283
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0165005
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0164628
TPI1 triosephosphate isomerase 1 -0.0164348
KMT2E lysine (K)-specific methyltransferase 2E -0.0163624
SAA2 serum amyloid A2 -0.0163117
WASF2 WAS protein family, member 2 -0.0162956
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0162688
RPL19 ribosomal protein L19 -0.0160375
SCARB1 scavenger receptor class B, member 1 -0.015928
TMOD3 tropomodulin 3 (ubiquitous) -0.0156781
CUL3 cullin 3 -0.0156404