Acetohexamide_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.16688
AKAP12 A kinase (PRKA) anchor protein 12 0.145592
ERRFI1 ERBB receptor feedback inhibitor 1 0.123465
DSPP dentin sialophosphoprotein 0.103535
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0968397
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0791847
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0655679
FNDC3B fibronectin type III domain containing 3B 0.0569329
ELL2 elongation factor, RNA polymerase II, 2 0.0569063
SAMD4A sterile alpha motif domain containing 4A 0.0562616
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0532652
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0521345
EHBP1 EH domain binding protein 1 0.0492125
SVIL supervillin 0.0490192
JMJD1C jumonji domain containing 1C 0.044908
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0435728
LRMDA leucine rich melanocyte differentiation associated 0.0426086
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0415626
PEG3 paternally expressed 3 0.0383345
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0372131
ASPH aspartate beta-hydroxylase 0.0362975
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0355728
RUNX1 runt-related transcription factor 1 0.0349614
TNS1 tensin 1 0.0340145
MYH9 myosin, heavy chain 9, non-muscle 0.0338149
AFDN afadin, adherens junction formation factor 0.0330089
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0329589
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0329177
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0325937
NKD1 naked cuticle homolog 1 (Drosophila) 0.0324098
H1-0 H1.0 linker histone 0.0314592
ATXN1 ataxin 1 0.030807
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0305469
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0298917
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0296153
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0288958
MAML2 mastermind-like 2 (Drosophila) 0.0286396
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0279342
DOCK5 dedicator of cytokinesis 5 0.027199
SMAD3 SMAD family member 3 0.0270259
DST dystonin 0.025679
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0249956
GSE1 Gse1 coiled-coil protein 0.0249771
FRMD5 FERM domain containing 5 0.0247467
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0245818
DLC1 DLC1 Rho GTPase activating protein 0.0245007
ANO6 anoctamin 6 0.0245006
VCL vinculin 0.0239673
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0237557
ARHGAP9 Rho GTPase activating protein 9 0.023443
ZMYND8 zinc finger, MYND-type containing 8 0.0230326
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0224851
KIAA1217 KIAA1217 0.0223793
SESTD1 SEC14 and spectrin domains 1 0.0221184
FTH1 ferritin, heavy polypeptide 1 0.0217919
SOX5 SRY (sex determining region Y)-box 5 0.021637
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0216211
NRIP1 nuclear receptor interacting protein 1 0.0215543
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0214776
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.021466
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0214204
TAS2R14 taste receptor, type 2, member 14 0.0213474
FAT1 FAT atypical cadherin 1 0.0212558
NGLY1 N-glycanase 1 0.0208154
RBM39 RNA binding motif protein 39 0.0207516
OSMR oncostatin M receptor 0.0204562
DOCK4 dedicator of cytokinesis 4 0.0202208
KDM3A lysine (K)-specific demethylase 3A 0.0201066
PTPRM protein tyrosine phosphatase, receptor type, M 0.0199614
WWC2 WW and C2 domain containing 2 0.0198895
LMCD1 LIM and cysteine-rich domains 1 0.019889
TRIO trio Rho guanine nucleotide exchange factor 0.0198656
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0197369
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0196761
ARFGEF3 ARFGEF family member 3 0.0193033
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0192285
ZMIZ1 zinc finger, MIZ-type containing 1 0.0190976
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0188849
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0187824
AFF1 AF4/FMR2 family, member 1 0.0187608
KIZ kizuna centrosomal protein 0.0186889
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.018632
EIF4B eukaryotic translation initiation factor 4B 0.0186248
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0186245
ESYT2 extended synaptotagmin-like protein 2 0.0185727
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.018413
ARHGAP5 Rho GTPase activating protein 5 0.0181907
LCOR ligand dependent nuclear receptor corepressor 0.0181334
GPC6 glypican 6 0.0179736
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0179512
DSCAM Down syndrome cell adhesion molecule 0.0179502
NPAS2 neuronal PAS domain protein 2 0.0176343
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0176218
KIF1B kinesin family member 1B 0.0176125
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0175991
ZFAND3 zinc finger, AN1-type domain 3 0.0175621
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 0.0175559
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0175025
SBF2 SET binding factor 2 0.0174846
ABTB3 ankyrin repeat and BTB domain containing 3 0.0173465

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.301818
MT2A metallothionein 2A -0.208115
IGF2 insulin-like growth factor 2 -0.190429
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101506
IGFBP1 insulin-like growth factor binding protein 1 -0.0928268
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0910948
APOA2 apolipoprotein A-II -0.0887711
FTL ferritin, light polypeptide -0.0878359
RPS6 ribosomal protein S6 -0.0747859
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0570638
RPS19 ribosomal protein S19 -0.0560741
RPS8 ribosomal protein S8 -0.0553281
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.055286
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0544572
RPS12 ribosomal protein S12 -0.054342
TPT1 tumor protein, translationally-controlled 1 -0.0521952
RPL35A ribosomal protein L35a -0.051539
RPLP1 ribosomal protein, large, P1 -0.0502888
AHSG alpha-2-HS-glycoprotein -0.0470858
GPC3 glypican 3 -0.046884
FBF1 Fas (TNFRSF6) binding factor 1 -0.0465225
RPLP0 ribosomal protein, large, P0 -0.0461797
APOA1 apolipoprotein A-I -0.0457869
TMSB10 thymosin beta 10 -0.045172
RPL11 ribosomal protein L11 -0.0447185
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0446111
RPL37A ribosomal protein L37a -0.0430872
CCL20 chemokine (C-C motif) ligand 20 -0.0424008
RPL23 ribosomal protein L23 -0.0422629
RPL31 ribosomal protein L31 -0.0399202
RPL12 ribosomal protein L12 -0.0394959
RPL36 ribosomal protein L36 -0.0389234
RPLP2 ribosomal protein, large, P2 -0.0382823
RPS5 ribosomal protein S5 -0.0374466
RPS24 ribosomal protein S24 -0.0356745
RPL9 ribosomal protein L9 -0.0356313
APOE apolipoprotein E -0.035586
RPS13 ribosomal protein S13 -0.0340062
RPS23 ribosomal protein S23 -0.0337426
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0337202
RPL34 ribosomal protein L34 -0.0337179
PTMA prothymosin, alpha -0.033572
RPS27A ribosomal protein S27a -0.0325657
AMBP alpha-1-microglobulin/bikunin precursor -0.0325332
RPL5 ribosomal protein L5 -0.0321817
B2M beta-2-microglobulin -0.0308322
RPS3 ribosomal protein S3 -0.029882
RPS29 ribosomal protein S29 -0.0297895
RPL32 ribosomal protein L32 -0.0286554
RPS25 ribosomal protein S25 -0.0284103
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0276293
RPL19 ribosomal protein L19 -0.0274549
DDIT4 DNA-damage-inducible transcript 4 -0.0269614
RPS21 ribosomal protein S21 -0.026933
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0240519
RPS10 ribosomal protein S10 -0.0240071
CPE carboxypeptidase E -0.02361
S100A9 S100 calcium binding protein A9 -0.0234546
RPS14 ribosomal protein S14 -0.0233805
MT1X metallothionein 1X -0.0226442
RPS11 ribosomal protein S11 -0.022394
RACK1 receptor for activated C kinase 1 -0.0221112
CST3 cystatin C -0.0221095
RPL38 ribosomal protein L38 -0.0211717
ATP5F1E ATP synthase F1 subunit epsilon -0.0208177
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0207047
RPL7A ribosomal protein L7a -0.020346
LDHA lactate dehydrogenase A -0.0200451
IER3 immediate early response 3 -0.0193037
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0193032
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0192578
IFITM3 interferon induced transmembrane protein 3 -0.0191856
PKM pyruvate kinase, muscle -0.0189818
ICAM1 intercellular adhesion molecule 1 -0.0189361
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0188989
PCBP2 poly(rC) binding protein 2 -0.0188161
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0186446
RPL10A ribosomal protein L10a -0.0186188
RPL8 ribosomal protein L8 -0.0181633
RPL27 ribosomal protein L27 -0.018116
GNAS GNAS complex locus -0.0179645
IL32 interleukin 32 -0.0179514
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0175762
IFITM1 interferon induced transmembrane protein 1 -0.017368
RPS16 ribosomal protein S16 -0.0170574
PEBP1 phosphatidylethanolamine binding protein 1 -0.0168564
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0167601
RPL27A ribosomal protein L27a -0.0166951
CALR calreticulin -0.0165025
RAN RAN, member RAS oncogene family -0.016409
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.01624
ACTG1 actin gamma 1 -0.0161603
RPS17 ribosomal protein S17 -0.0161557
RPL15 ribosomal protein L15 -0.0160937
RPL28 ribosomal protein L28 -0.0160209
VDAC1 voltage-dependent anion channel 1 -0.0159376
RPL26 ribosomal protein L26 -0.015683
TRIM26 tripartite motif containing 26 -0.0156582
RPL30 ribosomal protein L30 -0.0151028
RPS4X ribosomal protein S4, X-linked -0.0150661