Acetohexamide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.104501
ESYT2 extended synaptotagmin-like protein 2 0.0898564
CEMIP cell migration inducing protein, hyaluronan binding 0.0855277
MYOF myoferlin 0.0821747
CD44 CD44 molecule (Indian blood group) 0.0791212
FNDC3B fibronectin type III domain containing 3B 0.0760502
LMO7 LIM domain 7 0.0758598
NRIP1 nuclear receptor interacting protein 1 0.0732647
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0724949
MBNL2 muscleblind-like splicing regulator 2 0.0712804
NAMPT nicotinamide phosphoribosyltransferase 0.070801
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0657204
DST dystonin 0.0646189
BARX2 BARX homeobox 2 0.0604404
MTSS1 metastasis suppressor 1 0.0598049
KRT17 keratin 17, type I 0.0590817
RPS6 ribosomal protein S6 0.0551592
FTH1 ferritin, heavy polypeptide 1 0.0551551
RBM39 RNA binding motif protein 39 0.0526721
PTK2 protein tyrosine kinase 2 0.0520126
KTN1 kinectin 1 (kinesin receptor) 0.0514658
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0506498
FNIP1 folliculin interacting protein 1 0.0479969
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0477316
YBX1 Y box binding protein 1 0.0467738
DOCK5 dedicator of cytokinesis 5 0.0466621
CUL4B cullin 4B 0.0452153
TGM2 transglutaminase 2 0.044213
PDE4D phosphodiesterase 4D, cAMP-specific 0.0438024
EZR ezrin 0.0424514
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0422801
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0419796
MEF2A myocyte enhancer factor 2A 0.0414243
SQLE squalene epoxidase 0.0411234
MBNL1 muscleblind-like splicing regulator 1 0.0404286
CLU clusterin 0.040274
SMAD3 SMAD family member 3 0.0392227
RAI14 retinoic acid induced 14 0.0387865
KMT2E lysine (K)-specific methyltransferase 2E 0.0385718
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0383643
UBE2H ubiquitin-conjugating enzyme E2H 0.0382041
PALLD palladin, cytoskeletal associated protein 0.0374639
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0370713
AFAP1 actin filament associated protein 1 0.0370269
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0370003
TSC22D1 TSC22 domain family, member 1 0.0369112
MACF1 microtubule-actin crosslinking factor 1 0.0367722
FOXP1 forkhead box P1 0.0356712
FN1 fibronectin 1 0.0354933
PGK1 phosphoglycerate kinase 1 0.0343177
ARHGAP21 Rho GTPase activating protein 21 0.0342056
LIFR leukemia inhibitory factor receptor alpha 0.0339279
CANX calnexin 0.0338101
ARRDC3 arrestin domain containing 3 0.0337939
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0336734
DENND4C DENN/MADD domain containing 4C 0.0334618
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0333903
GATA6 GATA binding protein 6 0.0329679
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0322281
APLP2 amyloid beta (A4) precursor-like protein 2 0.0320357
UGCG UDP-glucose ceramide glucosyltransferase 0.0313605
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0313518
RAB22A RAB22A, member RAS oncogene family 0.0313308
OSMR oncostatin M receptor 0.0312037
NDRG1 N-myc downstream regulated 1 0.0311426
COG5 component of oligomeric golgi complex 5 0.0306327
RNF145 ring finger protein 145 0.0303496
KDM6A lysine (K)-specific demethylase 6A 0.0301884
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0301349
LRRC8C leucine rich repeat containing 8 family, member C 0.0300344
ENO1 enolase 1, (alpha) 0.0300123
AOPEP aminopeptidase O (putative) 0.0299927
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0298564
CPNE1 copine I 0.0297247
AKAP13 A kinase (PRKA) anchor protein 13 0.0296868
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0295177
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0294292
WASF2 WAS protein family, member 2 0.0293468
MATR3 matrin 3 0.02896
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0288661
RPL4 ribosomal protein L4 0.0287989
TMOD3 tropomodulin 3 (ubiquitous) 0.0287156
KDM2A lysine (K)-specific demethylase 2A 0.0286214
ADAM10 ADAM metallopeptidase domain 10 0.0281448
JAG1 jagged 1 0.0279005
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0278551
ITCH itchy E3 ubiquitin protein ligase 0.0275795
STAU1 staufen double-stranded RNA binding protein 1 0.0274088
STC1 stanniocalcin 1 0.0273742
EFNB2 ephrin-B2 0.0273295
JAK1 Janus kinase 1 0.0273263
ARID4B AT rich interactive domain 4B (RBP1-like) 0.027236
CD99 CD99 molecule 0.0271104
METTL15 methyltransferase like 15 0.0271102
ANXA1 annexin A1 0.0270071
GNAS GNAS complex locus 0.0269095
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0267467
NUMB numb homolog (Drosophila) 0.026692
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0266887
IRS2 insulin receptor substrate 2 0.0265545

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.162511
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.132114
TPT1 tumor protein, translationally-controlled 1 -0.0842293
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0800186
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0697961
DPYD dihydropyrimidine dehydrogenase -0.0619239
SLC35F3 solute carrier family 35, member F3 -0.0554565
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0520109
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.04906
SULF1 sulfatase 1 -0.0488888
EGR1 early growth response 1 -0.0456874
INTS6 integrator complex subunit 6 -0.0451019
PODXL podocalyxin-like -0.0445223
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0402749
PDLIM5 PDZ and LIM domain 5 -0.0402245
RAB7A RAB7A, member RAS oncogene family -0.0401491
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0380061
LAMC2 laminin, gamma 2 -0.0376606
NAV2 neuron navigator 2 -0.0361713
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0357536
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0355258
RPL37A ribosomal protein L37a -0.0352388
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0348226
ABI3BP ABI family, member 3 (NESH) binding protein -0.0330046
S100A11 S100 calcium binding protein A11 -0.0329633
ACTG1 actin gamma 1 -0.0329127
RPS24 ribosomal protein S24 -0.0328391
MSN moesin -0.0328364
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0323129
ACTN4 actinin, alpha 4 -0.0318054
CRACDL CRACD like -0.0313338
CSMD2 CUB and Sushi multiple domains 2 -0.0312636
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0312281
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0312182
IFI6 interferon, alpha-inducible protein 6 -0.0309648
ACTN1 actinin, alpha 1 -0.0305552
C4BPB complement component 4 binding protein, beta -0.0301994
DSG2 desmoglein 2 -0.0300616
CAV1 caveolin 1, caveolae protein, 22kDa -0.0292884
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0292488
FRMD4B FERM domain containing 4B -0.0282834
RPS21 ribosomal protein S21 -0.0281423
RRBP1 ribosome binding protein 1 -0.0280915
RPS12 ribosomal protein S12 -0.027912
MT2A metallothionein 2A -0.0277066
RASAL2 RAS protein activator like 2 -0.0273465
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.027311
RPS3 ribosomal protein S3 -0.0268354
RAD51B RAD51 paralog B -0.0267582
RCOR1 REST corepressor 1 -0.0265061
ASPH aspartate beta-hydroxylase -0.0258466
PPIA peptidylprolyl isomerase A (cyclophilin A) -0.0256907
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0249736
RIGI RNA sensor RIG-I -0.0247089
RGS4 regulator of G-protein signaling 4 -0.0238577
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0235809
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0235042
CSTB cystatin B (stefin B) -0.0233275
MAML2 mastermind-like 2 (Drosophila) -0.0231171
KISS1 KiSS-1 metastasis-suppressor -0.0228865
LY6E lymphocyte antigen 6 complex, locus E -0.0225878
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0225163
COL17A1 collagen, type XVII, alpha 1 -0.022475
MYO10 myosin X -0.0222277
HLA-B major histocompatibility complex, class I, B -0.0221337
SQSTM1 sequestosome 1 -0.0220015
FERMT1 fermitin family member 1 -0.0213739
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0211523
TM4SF1 transmembrane 4 L six family member 1 -0.0208148
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0206425
IFI44 interferon-induced protein 44 -0.0205577
THBD thrombomodulin -0.020486
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0203594
SOX5 SRY (sex determining region Y)-box 5 -0.0202059
AGMO alkylglycerol monooxygenase -0.0200629
ALCAM activated leukocyte cell adhesion molecule -0.0200573
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0198803
ANO1 anoctamin 1, calcium activated chloride channel -0.0198268
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 -0.0197902
RPL36A ribosomal protein L36a -0.0197478
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -0.0195309
COL5A1 collagen, type V, alpha 1 -0.0193133
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0189808
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -0.0183365
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0179629
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.0178876
MYL12B myosin, light chain 12B, regulatory -0.017765
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0177644
WSB1 WD repeat and SOCS box containing 1 -0.0176985
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0176257
ECE1 endothelin converting enzyme 1 -0.0175406
MECOM MDS1 and EVI1 complex locus -0.0174542
SOX13 SRY (sex determining region Y)-box 13 -0.0174158
CD59 CD59 molecule, complement regulatory protein -0.0173767
TJP1 tight junction protein 1 -0.0172815
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0169483
OCIAD2 OCIA domain containing 2 -0.0168391
ABLIM3 actin binding LIM protein family, member 3 -0.0167768
CD9 CD9 molecule -0.0166814
VCL vinculin -0.0166341