Acetohexamide_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.125268
MT2A metallothionein 2A 0.118742
EGFR epidermal growth factor receptor 0.109543
PDE4D phosphodiesterase 4D, cAMP-specific 0.0702251
GRAMD1B GRAM domain containing 1B 0.0656719
SLTM SAFB-like, transcription modulator 0.0636592
OSMR oncostatin M receptor 0.0538732
THSD4 thrombospondin, type I, domain containing 4 0.053443
CES1 carboxylesterase 1 0.0523413
AGO2 argonaute RISC catalytic component 2 0.0520539
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0518316
MCTP1 multiple C2 domains, transmembrane 1 0.0504732
ELL2 elongation factor, RNA polymerase II, 2 0.04958
TBC1D22A TBC1 domain family, member 22A 0.0487756
DOCK5 dedicator of cytokinesis 5 0.0462275
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0421756
RUNX1 runt-related transcription factor 1 0.0390152
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0387889
EFNA5 ephrin-A5 0.0380958
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0373567
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.037035
NAMPT nicotinamide phosphoribosyltransferase 0.0363879
LAMA4 laminin, alpha 4 0.0361209
SMYD3 SET and MYND domain containing 3 0.0353508
MKI67 marker of proliferation Ki-67 0.0343954
SMAD3 SMAD family member 3 0.0341739
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0339675
SAMD4A sterile alpha motif domain containing 4A 0.0337819
GCLC glutamate-cysteine ligase, catalytic subunit 0.0323536
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0323526
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.032298
FTH1 ferritin, heavy polypeptide 1 0.0317663
LRP1B low density lipoprotein receptor-related protein 1B 0.0296302
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0290482
JMJD1C jumonji domain containing 1C 0.0285404
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0272731
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0270229
PM20D1 peptidase M20 domain containing 1 0.0266602
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0255443
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0254918
DSCAM Down syndrome cell adhesion molecule 0.0253983
TRAPPC9 trafficking protein particle complex 9 0.0249487
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0248468
ZNF638 zinc finger protein 638 0.0245053
LGALS12 lectin, galactoside-binding, soluble, 12 0.0242134
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0238902
MGST1 microsomal glutathione S-transferase 1 0.0238786
GPHN gephyrin 0.0232878
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0232665
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0231381
DTNA dystrobrevin, alpha 0.0226999
ATP11A ATPase, class VI, type 11A 0.0225289
EPAS1 endothelial PAS domain protein 1 0.0223764
EXT1 exostosin glycosyltransferase 1 0.0222319
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0222121
CEMIP cell migration inducing protein, hyaluronan binding 0.0215515
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0215265
MCL1 myeloid cell leukemia 1 0.0212808
MYOF myoferlin 0.0211233
BCAR3 breast cancer anti-estrogen resistance 3 0.0209731
CXCL8 chemokine (C-X-C motif) ligand 8 0.0209406
SYAP1 synapse associated protein 1 0.020572
USP34 ubiquitin specific peptidase 34 0.0203623
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0203019
NPC1 Niemann-Pick disease, type C1 0.0202167
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0198819
LOC112694756 uncharaterized LOC112694756 0.0198251
TRIP12 thyroid hormone receptor interactor 12 0.019729
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0196619
RTN4 reticulon 4 0.0196399
NABP1 nucleic acid binding protein 1 0.0195011
LAMC2 laminin, gamma 2 0.0193
ZBTB20 zinc finger and BTB domain containing 20 0.0191835
MT1X metallothionein 1X 0.0191086
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0190544
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.01882
DOCK1 dedicator of cytokinesis 1 0.018769
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.018666
MYH9 myosin, heavy chain 9, non-muscle 0.018421
ARB2A ARB2 cotranscriptional regulator A 0.0183504
GPATCH2L G patch domain containing 2-like 0.0182451
FOXP1 forkhead box P1 0.0181954
SCLT1 sodium channel and clathrin linker 1 0.0179436
ERRFI1 ERBB receptor feedback inhibitor 1 0.0179352
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0177352
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0173814
WDR26 WD repeat domain 26 0.0173368
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0173001
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0169985
KIAA1328 KIAA1328 0.0168483
BABAM2 BRISC and BRCA1 A complex member 2 0.0167809
TRIO trio Rho guanine nucleotide exchange factor 0.0166957
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0165642
FAF1 Fas (TNFRSF6) associated factor 1 0.0165601
ZNF292 zinc finger protein 292 0.0165439
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0164797
LPP LIM domain containing preferred translocation partner in lipoma 0.016111
KYNU kynureninase 0.016109
PRKCE protein kinase C, epsilon 0.0158492
NIPBL Nipped-B homolog (Drosophila) 0.0158218

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.104914
PTMA prothymosin, alpha -0.0889936
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0813641
ACTG1 actin gamma 1 -0.0633092
S100A10 S100 calcium binding protein A10 -0.0564253
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.048103
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0451304
TPT1 tumor protein, translationally-controlled 1 -0.0449951
NDRG1 N-myc downstream regulated 1 -0.0427972
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0401784
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.03679
KRT18 keratin 18, type I -0.0318429
EGR1 early growth response 1 -0.0310068
LDHA lactate dehydrogenase A -0.0283811
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0282075
IFI6 interferon, alpha-inducible protein 6 -0.0273866
CST3 cystatin C -0.0271088
WASF2 WAS protein family, member 2 -0.0264825
RPS25 ribosomal protein S25 -0.0264154
PDIA3 protein disulfide isomerase family A, member 3 -0.0259652
S100A6 S100 calcium binding protein A6 -0.025094
AGR2 anterior gradient 2 -0.0240291
ASPH aspartate beta-hydroxylase -0.0239987
PDE8A phosphodiesterase 8A -0.0236966
LMO7 LIM domain 7 -0.0233437
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0231684
KRT7 keratin 7, type II -0.0230087
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0221192
PKM pyruvate kinase, muscle -0.0220284
SEC31A SEC31 homolog A (S. cerevisiae) -0.0219675
KRT19 keratin 19, type I -0.0211796
H1-0 H1.0 linker histone -0.0210269
HDLBP high density lipoprotein binding protein -0.0199038
HMGA1 high mobility group AT-hook 1 -0.019902
PDIA6 protein disulfide isomerase family A, member 6 -0.0189548
HLA-B major histocompatibility complex, class I, B -0.0189205
HILPDA hypoxia inducible lipid droplet-associated -0.0185715
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0185303
GNAS GNAS complex locus -0.0181869
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0178714
RPS24 ribosomal protein S24 -0.0177628
RPL35A ribosomal protein L35a -0.0173765
FTL ferritin, light polypeptide -0.0171748
RAB1A RAB1A, member RAS oncogene family -0.0171359
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0169914
ANXA2 annexin A2 -0.015972
POTEF POTE ankyrin domain family, member F -0.0158694
RPL31 ribosomal protein L31 -0.0154254
TPM4 tropomyosin 4 -0.0153971
IGFBP3 insulin-like growth factor binding protein 3 -0.0151114
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0150878
ENO1 enolase 1, (alpha) -0.0149603
BMP7 bone morphogenetic protein 7 -0.0147586
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0145871
TMEM165 transmembrane protein 165 -0.0144828
CD163L1 CD163 molecule-like 1 -0.014477
HYOU1 hypoxia up-regulated 1 -0.0143311
ENO2 enolase 2 (gamma, neuronal) -0.0142777
TTC3 tetratricopeptide repeat domain 3 -0.0142016
BZW1 basic leucine zipper and W2 domains 1 -0.0141335
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0139625
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0137657
IGFBP5 insulin-like growth factor binding protein 5 -0.0137437
RPS12 ribosomal protein S12 -0.013704
SPIRE1 spire-type actin nucleation factor 1 -0.0136063
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0135976
FNDC3B fibronectin type III domain containing 3B -0.0135024
IER3 immediate early response 3 -0.0134692
RPL37 ribosomal protein L37 -0.0134156
RPS8 ribosomal protein S8 -0.0134065
RPS13 ribosomal protein S13 -0.0133947
CALR calreticulin -0.0130987
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0130784
CD99 CD99 molecule -0.0128914
SOD2 superoxide dismutase 2, mitochondrial -0.012814
SRP54 signal recognition particle 54kDa -0.012803
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0127627
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0126678
RAP1B RAP1B, member of RAS oncogene family -0.0124083
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0123409
BIRC6 baculoviral IAP repeat containing 6 -0.0122254
UBC ubiquitin C -0.01218
DDIT4 DNA-damage-inducible transcript 4 -0.012118
PERP PERP, TP53 apoptosis effector -0.0120762
CCNY cyclin Y -0.0120334
LOC102724023 ES1 protein homolog, mitochondrial -0.0119807
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0118632
NPTX1 neuronal pentraxin I -0.0116643
MXI1 MAX interactor 1, dimerization protein -0.0115019
WDR45B WD repeat domain 45B -0.0113985
UPP1 uridine phosphorylase 1 -0.0113253
SQSTM1 sequestosome 1 -0.0112056
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0111908
CANX calnexin -0.0110775
FA2H fatty acid 2-hydroxylase -0.0109701
RAB27B RAB27B, member RAS oncogene family -0.0109367
KMT2E lysine (K)-specific methyltransferase 2E -0.0108925
RPS27A ribosomal protein S27a -0.0108541
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.010821
KCMF1 potassium channel modulatory factor 1 -0.0107741