| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Acetohexamide perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Acetohexamide_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.0950218 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.090329 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0679388 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0582828 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0574049 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0557079 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.054025 |
| MCL1 | myeloid cell leukemia 1 | 0.0526247 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0457018 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0395384 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0392635 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0377856 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0364728 |
| COPA | coatomer protein complex, subunit alpha | 0.0355203 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0346314 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0345448 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0327813 |
| IL6 | interleukin 6 | 0.0326858 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0312798 |
| GOLGA4 | golgin A4 | 0.0312519 |
| FAM107B | family with sequence similarity 107, member B | 0.0310633 |
| BMP6 | bone morphogenetic protein 6 | 0.0309143 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0306595 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0306178 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0289406 |
| MYO1E | myosin IE | 0.028927 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0289184 |
| ATXN1 | ataxin 1 | 0.0271507 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.027076 |
| PDE8A | phosphodiesterase 8A | 0.0263279 |
| POTEF | POTE ankyrin domain family, member F | 0.0263126 |
| ATP11A | ATPase, class VI, type 11A | 0.0260467 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0259428 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0259271 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0257191 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0255351 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0254199 |
| NDRG1 | N-myc downstream regulated 1 | 0.0250234 |
| ITGB5 | integrin, beta 5 | 0.0249773 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0242735 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0238749 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0237442 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0236795 |
| CDCP1 | CUB domain containing protein 1 | 0.0235088 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0234192 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0230512 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0227891 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0227512 |
| CD44 | CD44 molecule (Indian blood group) | 0.0225583 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0224766 |
| SNX14 | sorting nexin 14 | 0.022262 |
| MAX | MYC associated factor X | 0.0221078 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0217435 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0215904 |
| RCOR1 | REST corepressor 1 | 0.0213369 |
| CALD1 | caldesmon 1 | 0.0209324 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0204028 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0201991 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.020126 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.020002 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.019917 |
| USP53 | ubiquitin specific peptidase 53 | 0.0197867 |
| LAMC2 | laminin, gamma 2 | 0.0197355 |
| VMP1 | vacuole membrane protein 1 | 0.0195904 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0188452 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0188094 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0184441 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.018273 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0180829 |
| SRP54 | signal recognition particle 54kDa | 0.0180706 |
| CMIP | c-Maf inducing protein | 0.0180163 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0179469 |
| USP36 | ubiquitin specific peptidase 36 | 0.0178234 |
| MAP7 | microtubule-associated protein 7 | 0.017814 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 0.0177727 |
| HM13 | histocompatibility (minor) 13 | 0.0176267 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0174552 |
| VCL | vinculin | 0.0173213 |
| PMM2 | phosphomannomutase 2 | 0.0171256 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.017123 |
| OSMR | oncostatin M receptor | 0.0170395 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0169575 |
| TGM2 | transglutaminase 2 | 0.0166709 |
| NEMF | nuclear export mediator factor | 0.0164761 |
| MSN | moesin | 0.0164704 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0162699 |
| HLA-B | major histocompatibility complex, class I, B | 0.0162007 |
| RPS8 | ribosomal protein S8 | 0.0161946 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0161131 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0161124 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0160746 |
| FLNB | filamin B, beta | 0.016037 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0157817 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0157735 |
| HLA-A | major histocompatibility complex, class I, A | 0.0157275 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0157156 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.015503 |
| EGR1 | early growth response 1 | 0.0154154 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0152948 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0152896 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.193934 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.173458 |
| FTL | ferritin, light polypeptide | -0.145518 |
| TMSB10 | thymosin beta 10 | -0.141894 |
| MT2A | metallothionein 2A | -0.125322 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.105906 |
| PTMA | prothymosin, alpha | -0.0837805 |
| VIM | vimentin | -0.0789554 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0777328 |
| GRAMD1B | GRAM domain containing 1B | -0.0694517 |
| RPL19 | ribosomal protein L19 | -0.0669792 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.066013 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0643858 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0628671 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0611274 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0586522 |
| RPL23 | ribosomal protein L23 | -0.0537113 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0536521 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.051412 |
| HDAC9 | histone deacetylase 9 | -0.0513848 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0502367 |
| BICC1 | BicC family RNA binding protein 1 | -0.0484285 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.04457 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0422366 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0418554 |
| RPLP0 | ribosomal protein, large, P0 | -0.0415787 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0413186 |
| ECT2 | epithelial cell transforming 2 | -0.0410865 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0404923 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0402063 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.039362 |
| RPS21 | ribosomal protein S21 | -0.0372666 |
| YBX3 | Y box binding protein 3 | -0.0369529 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0369293 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0368213 |
| RPL8 | ribosomal protein L8 | -0.036712 |
| YBX1 | Y box binding protein 1 | -0.0361142 |
| DST | dystonin | -0.0357706 |
| FGB | fibrinogen beta chain | -0.0357627 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.034986 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0348496 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0341645 |
| CAVIN1 | caveolae associated protein 1 | -0.0339362 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0329728 |
| RHOA | ras homolog family member A | -0.0325934 |
| APP | amyloid beta (A4) precursor protein | -0.0325723 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0319231 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0313499 |
| AHNAK | AHNAK nucleoprotein | -0.0313086 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0311508 |
| WDR43 | WD repeat domain 43 | -0.0306593 |
| MORF4L1 | mortality factor 4 like 1 | -0.0305228 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0301386 |
| RHEB | Ras homolog enriched in brain | -0.0299645 |
| TMEM123 | transmembrane protein 123 | -0.0298902 |
| ERBIN | erbb2 interacting protein | -0.029748 |
| RPS5 | ribosomal protein S5 | -0.0294561 |
| TPX2 | TPX2, microtubule-associated | -0.0293731 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0293387 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0292692 |
| RTN4 | reticulon 4 | -0.0284835 |
| TNPO1 | transportin 1 | -0.0283073 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0281723 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0279076 |
| SEPTIN7 | septin 7 | -0.0278587 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0276571 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0276266 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0275882 |
| KIF5B | kinesin family member 5B | -0.0275309 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0274122 |
| USP34 | ubiquitin specific peptidase 34 | -0.027239 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0267709 |
| ZFHX3 | zinc finger homeobox 3 | -0.0267556 |
| IGF2 | insulin-like growth factor 2 | -0.0267501 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0266285 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0263432 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0262473 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0261367 |
| RPS19 | ribosomal protein S19 | -0.026096 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.0260205 |
| RPL18 | ribosomal protein L18 | -0.0257478 |
| AHR | aryl hydrocarbon receptor | -0.0254013 |
| HMGA1 | high mobility group AT-hook 1 | -0.0252678 |
| ANLN | anillin, actin binding protein | -0.0249388 |
| ASPH | aspartate beta-hydroxylase | -0.0249122 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0248257 |
| ILF2 | interleukin enhancer binding factor 2 | -0.0247941 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0247046 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0246444 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0246338 |
| MKI67 | marker of proliferation Ki-67 | -0.024621 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0245814 |
| LMNA | lamin A/C | -0.0245798 |
| RBM39 | RNA binding motif protein 39 | -0.0245495 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.024184 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.024109 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0239933 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0239613 |
| RPL4 | ribosomal protein L4 | -0.0238872 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0237164 |
