Acetohexamide_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.136381
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.102301
TPT1 tumor protein, translationally-controlled 1 0.0856115
AKAP12 A kinase (PRKA) anchor protein 12 0.0824909
EFNA5 ephrin-A5 0.081782
STC1 stanniocalcin 1 0.075646
EGFR epidermal growth factor receptor 0.0730121
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.072439
TMSB10 thymosin beta 10 0.0704009
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0641839
PDE4D phosphodiesterase 4D, cAMP-specific 0.0639319
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0620948
RPS12 ribosomal protein S12 0.0605488
RPS8 ribosomal protein S8 0.0602988
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0559453
RPL15 ribosomal protein L15 0.0557909
RPL37A ribosomal protein L37a 0.052531
LMO7 LIM domain 7 0.0521383
TM4SF1 transmembrane 4 L six family member 1 0.0518454
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0509228
GOLGA4 golgin A4 0.0506211
BCAR3 breast cancer anti-estrogen resistance 3 0.0494101
MT2A metallothionein 2A 0.0489238
LAMC2 laminin, gamma 2 0.043424
MBD5 methyl-CpG binding domain protein 5 0.0429626
PRKCA protein kinase C, alpha 0.0403609
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0401483
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.0397959
TPM4 tropomyosin 4 0.0391805
FNDC3B fibronectin type III domain containing 3B 0.0371833
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0368858
FLNB filamin B, beta 0.0367318
DTNA dystrobrevin, alpha 0.0365082
RPS3 ribosomal protein S3 0.0348169
SOS1 son of sevenless homolog 1 (Drosophila) 0.0344968
RPS27A ribosomal protein S27a 0.0337694
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0335025
DLG1 discs, large homolog 1 (Drosophila) 0.0334146
MXD1 MAX dimerization protein 1 0.0329152
KIAA1328 KIAA1328 0.0328196
CLIP1 CAP-GLY domain containing linker protein 1 0.0327473
SCAF11 SR-related CTD-associated factor 11 0.0321635
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0319023
PPARD peroxisome proliferator-activated receptor delta 0.0316807
EIF1 eukaryotic translation initiation factor 1 0.0310979
BACE2 beta-site APP-cleaving enzyme 2 0.0309978
LPIN2 lipin 2 0.0305026
HDAC9 histone deacetylase 9 0.0302241
F3 coagulation factor III (thromboplastin, tissue factor) 0.0301112
DNAAF9 dynein axonemal assembly factor 9 0.0299634
NKD1 naked cuticle homolog 1 (Drosophila) 0.0297945
METTL15 methyltransferase like 15 0.0295993
RPL38 ribosomal protein L38 0.0292937
MAP1B microtubule-associated protein 1B 0.0290787
SMC5 structural maintenance of chromosomes 5 0.0289841
FTH1 ferritin, heavy polypeptide 1 0.0288141
MCL1 myeloid cell leukemia 1 0.0285852
C3 complement component 3 0.028522
ELL2 elongation factor, RNA polymerase II, 2 0.0284158
RPL31 ribosomal protein L31 0.0283901
CAPN2 calpain 2, (m/II) large subunit 0.0283601
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0282754
TAS2R14 taste receptor, type 2, member 14 0.0280587
SECISBP2L SECIS binding protein 2-like 0.028003
BPTF bromodomain PHD finger transcription factor 0.0279972
KIF5B kinesin family member 5B 0.0278075
KYNU kynureninase 0.0277666
FAM177A1 family with sequence similarity 177, member A1 0.0276725
RPS20 ribosomal protein S20 0.0276018
RPL37 ribosomal protein L37 0.0275411
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0271868
RBM39 RNA binding motif protein 39 0.0270726
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.026476
AKAP9 A kinase (PRKA) anchor protein 9 0.026038
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0259906
PTMA prothymosin, alpha 0.0258511
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0257272
ENO1 enolase 1, (alpha) 0.0257138
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0256226
RAB7A RAB7A, member RAS oncogene family 0.0255363
RPS15 ribosomal protein S15 0.025508
RPL26 ribosomal protein L26 0.0252349
RPL36 ribosomal protein L36 0.0250638
SEPTIN9 septin 9 0.0248764
FHIT fragile histidine triad 0.0247432
SACK1A scaffolding CK1 anchoring protein A 0.0245818
KDM3B lysine (K)-specific demethylase 3B 0.0245361
RPS13 ribosomal protein S13 0.0244898
FER fer (fps/fes related) tyrosine kinase 0.0242259
RPL35A ribosomal protein L35a 0.0241059
NALF1 NALCN channel auxiliary factor 1 0.0239893
DOCK4 dedicator of cytokinesis 4 0.0237505
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0237417
COL6A3 collagen, type VI, alpha 3 0.0234774
TBC1D5 TBC1 domain family, member 5 0.0234021
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0232075
HLA-A major histocompatibility complex, class I, A 0.023019
MYO9B myosin IXB 0.0228897
NBEA neurobeachin 0.0226891
RPS23 ribosomal protein S23 0.0226579

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.102332
NCOA3 nuclear receptor coactivator 3 -0.0980741
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.088528
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0750335
BTG1 B-cell translocation gene 1, anti-proliferative -0.0652445
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0645315
TRA2A transformer 2 alpha homolog (Drosophila) -0.0628702
KMT2C lysine (K)-specific methyltransferase 2C -0.0596039
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0586846
ATOSA atos homolog A -0.0543707
NAMPT nicotinamide phosphoribosyltransferase -0.0531368
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0528429
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0508282
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0500857
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0493153
MYO1E myosin IE -0.0486518
EPSTI1 epithelial stromal interaction 1 (breast) -0.0473624
FTL ferritin, light polypeptide -0.0470035
KMT2E lysine (K)-specific methyltransferase 2E -0.0468586
ANXA1 annexin A1 -0.0448495
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0435201
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0432004
RIOK3 RIO kinase 3 -0.0431788
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0426874
SRPK2 SRSF protein kinase 2 -0.0418754
ACBD3 acyl-CoA binding domain containing 3 -0.0418296
MTUS1 microtubule associated tumor suppressor 1 -0.0414524
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0413104
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0403442
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0400532
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0400089
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0397058
KAT6B K(lysine) acetyltransferase 6B -0.0395516
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0394758
FDPS farnesyl diphosphate synthase -0.0394113
SNX9 sorting nexin 9 -0.0392063
WDR26 WD repeat domain 26 -0.0391029
PDIA3 protein disulfide isomerase family A, member 3 -0.0385712
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0380352
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0373713
RPL23 ribosomal protein L23 -0.0369029
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0361332
KRT17 keratin 17, type I -0.0359712
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.035929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0358508
KDM3A lysine (K)-specific demethylase 3A -0.0351988
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0345853
ZMYND8 zinc finger, MYND-type containing 8 -0.0345417
USP3 ubiquitin specific peptidase 3 -0.0345127
ANXA2 annexin A2 -0.0344106
GCC2 GRIP and coiled-coil domain containing 2 -0.0341589
RAD23B RAD23 homolog B (S. cerevisiae) -0.034074
CCDC6 coiled-coil domain containing 6 -0.0337998
S100A8 S100 calcium binding protein A8 -0.0330203
CCNL1 cyclin L1 -0.0329283
LAMB3 laminin, beta 3 -0.0323854
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0321545
TPD52 tumor protein D52 -0.031749
ARHGAP21 Rho GTPase activating protein 21 -0.031654
TMEM123 transmembrane protein 123 -0.0314491
MIS18BP1 MIS18 binding protein 1 -0.0312242
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0305154
SREBF2 sterol regulatory element binding transcription factor 2 -0.0303866
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0300591
NHSL1 NHS-like 1 -0.0298368
LPP LIM domain containing preferred translocation partner in lipoma -0.0294977
LIMCH1 LIM and calponin homology domains 1 -0.0294306
ZNF292 zinc finger protein 292 -0.0292681
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0292087
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0291897
ZFAND3 zinc finger, AN1-type domain 3 -0.0289419
GCLC glutamate-cysteine ligase, catalytic subunit -0.0288265
SLMAP sarcolemma associated protein -0.0287237
PTBP3 polypyrimidine tract binding protein 3 -0.0286176
IGFBP3 insulin-like growth factor binding protein 3 -0.0286149
TNPO1 transportin 1 -0.0283984
DST dystonin -0.0283686
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0280883
BBX bobby sox homolog (Drosophila) -0.0279561
ADAM17 ADAM metallopeptidase domain 17 -0.0279018
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0277903
GPC6 glypican 6 -0.0276749
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0275905
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0274685
USP15 ubiquitin specific peptidase 15 -0.0273354
DENND1A DENN/MADD domain containing 1A -0.027284
COPA coatomer protein complex, subunit alpha -0.0270895
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0268914
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0268712
PTK2 protein tyrosine kinase 2 -0.0268454
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.026551
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0265176
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0265047
UBAP1 ubiquitin associated protein 1 -0.0263496
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.026229
CALR calreticulin -0.0261213
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0260782
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0260208
JUP junction plakoglobin -0.0257434
PRRC2C proline-rich coiled-coil 2C -0.0256403