Acetohexamide_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.0798699
TRIO trio Rho guanine nucleotide exchange factor 0.0581272
LIMCH1 LIM and calponin homology domains 1 0.0576629
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.049768
DST dystonin 0.0442546
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0413319
KYNU kynureninase 0.0403265
GDA guanine deaminase 0.0398549
PDE10A phosphodiesterase 10A 0.0385531
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0381048
MYOF myoferlin 0.0379758
TGFBR1 transforming growth factor, beta receptor 1 0.0340134
SAMD4A sterile alpha motif domain containing 4A 0.0331307
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0311536
SMOC1 SPARC related modular calcium binding 1 0.0299204
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0290419
PTEN phosphatase and tensin homolog 0.0277359
FLNB filamin B, beta 0.0268597
DOCK4 dedicator of cytokinesis 4 0.0267172
INTS6 integrator complex subunit 6 0.0263488
MCL1 myeloid cell leukemia 1 0.0263224
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.026298
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0261323
FNDC3B fibronectin type III domain containing 3B 0.0259283
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0255925
FMNL2 formin-like 2 0.025249
BIRC6 baculoviral IAP repeat containing 6 0.024804
DNER delta/notch-like EGF repeat containing 0.0243928
ZSWIM6 zinc finger, SWIM-type containing 6 0.0237127
ASPH aspartate beta-hydroxylase 0.0237078
VCL vinculin 0.0227875
SMAD2 SMAD family member 2 0.0216796
PDLIM5 PDZ and LIM domain 5 0.0213132
CARD16 caspase recruitment domain family, member 16 0.0208191
PCBP2 poly(rC) binding protein 2 0.0207661
PM20D1 peptidase M20 domain containing 1 0.0206642
ELL2 elongation factor, RNA polymerase II, 2 0.0203279
CXCL8 chemokine (C-X-C motif) ligand 8 0.0201832
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0200388
MAML3 mastermind-like 3 (Drosophila) 0.0200248
JMJD1C jumonji domain containing 1C 0.0194991
PTK2 protein tyrosine kinase 2 0.0193351
MCTP1 multiple C2 domains, transmembrane 1 0.018831
FNIP1 folliculin interacting protein 1 0.0187747
CTIF CBP80/20-dependent translation initiation factor 0.0186894
COPA coatomer protein complex, subunit alpha 0.0185564
NBAS neuroblastoma amplified sequence 0.0182842
RUNX1 runt-related transcription factor 1 0.0180323
LAMA1 laminin, alpha 1 0.0180304
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0179772
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0179712
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0178623
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0177944
CHD1 chromodomain helicase DNA binding protein 1 0.0171837
PUM2 pumilio RNA-binding family member 2 0.017079
ATP13A3 ATPase type 13A3 0.0168991
PLCB4 phospholipase C, beta 4 0.0168586
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.016854
WDR43 WD repeat domain 43 0.0167524
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0163096
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0162888
USP9X ubiquitin specific peptidase 9, X-linked 0.0161726
RTN4 reticulon 4 0.0161144
USP34 ubiquitin specific peptidase 34 0.0160017
NPAS2 neuronal PAS domain protein 2 0.0158741
COL4A6 collagen, type IV, alpha 6 0.0157328
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0153033
MON2 MON2 homolog (S. cerevisiae) 0.0152869
NEK7 NIMA-related kinase 7 0.0150652
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0150124
MSN moesin 0.0149013
ZCCHC7 zinc finger, CCHC domain containing 7 0.0147156
ADARB1 adenosine deaminase, RNA-specific, B1 0.0146213
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0145386
ANKRD17 ankyrin repeat domain 17 0.0144459
ZNF638 zinc finger protein 638 0.0143244
GPC6 glypican 6 0.0142029
COG5 component of oligomeric golgi complex 5 0.0141966
HELZ helicase with zinc finger 0.0141311
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0140465
MARCHF1 membrane associated ring-CH-type finger 1 0.0138927
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0138695
HDAC4 histone deacetylase 4 0.0138475
RNF145 ring finger protein 145 0.0136725
TXNRD1 thioredoxin reductase 1 0.0135291
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0134318
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0134117
SFPQ splicing factor proline/glutamine-rich 0.0133801
TRA2A transformer 2 alpha homolog (Drosophila) 0.0133742
AKAP13 A kinase (PRKA) anchor protein 13 0.013365
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0132722
STRN3 striatin, calmodulin binding protein 3 0.0132509
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0132364
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0132238
MBD5 methyl-CpG binding domain protein 5 0.0132232
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.01319
NCKAP1 NCK-associated protein 1 0.0131873
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0131703
KDM4C lysine (K)-specific demethylase 4C 0.013068
AGTPBP1 ATP/GTP binding protein 1 0.0130481

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.217621
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.1373
VIM vimentin -0.134744
PDE4D phosphodiesterase 4D, cAMP-specific -0.127451
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119424
TPT1 tumor protein, translationally-controlled 1 -0.103906
PTMA prothymosin, alpha -0.0967621
TMSB10 thymosin beta 10 -0.0888157
RPLP1 ribosomal protein, large, P1 -0.0867241
RPS6 ribosomal protein S6 -0.0814046
COL5A2 collagen, type V, alpha 2 -0.076972
RPS8 ribosomal protein S8 -0.0644713
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0635527
RPS24 ribosomal protein S24 -0.0631637
RPL31 ribosomal protein L31 -0.0569788
RPL12 ribosomal protein L12 -0.0562495
RPL35A ribosomal protein L35a -0.0549444
FTL ferritin, light polypeptide -0.0532732
RPS12 ribosomal protein S12 -0.0525222
RPL37A ribosomal protein L37a -0.0520669
RPL26 ribosomal protein L26 -0.052045
RPS19 ribosomal protein S19 -0.0513251
WARS1 tryptophanyl-tRNA synthetase 1 -0.0509452
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.050806
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0489884
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0484899
SOX4 SRY (sex determining region Y)-box 4 -0.0484692
RPL19 ribosomal protein L19 -0.0484169
RPL34 ribosomal protein L34 -0.0479794
RPL36A ribosomal protein L36a -0.0470696
HLA-B major histocompatibility complex, class I, B -0.046785
B2M beta-2-microglobulin -0.0420017
RPLP0 ribosomal protein, large, P0 -0.0418502
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0415348
RPS23 ribosomal protein S23 -0.0411248
RPS27A ribosomal protein S27a -0.0404606
RPS27 ribosomal protein S27 -0.0402978
ENO1 enolase 1, (alpha) -0.0402944
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0401463
IFIH1 interferon induced with helicase C domain 1 -0.0388347
CTSL cathepsin L -0.0374634
RPS3 ribosomal protein S3 -0.0368859
RPS14 ribosomal protein S14 -0.0367038
RPL23 ribosomal protein L23 -0.0359678
TM4SF1 transmembrane 4 L six family member 1 -0.035533
RPL37 ribosomal protein L37 -0.0353365
RPL38 ribosomal protein L38 -0.0352596
CDH13 cadherin 13 -0.034974
RPLP2 ribosomal protein, large, P2 -0.0348754
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0347441
RPS21 ribosomal protein S21 -0.0344461
S100A6 S100 calcium binding protein A6 -0.0342846
HLA-A major histocompatibility complex, class I, A -0.0335217
RPL7A ribosomal protein L7a -0.0332936
RPS16 ribosomal protein S16 -0.0332388
RPL9 ribosomal protein L9 -0.0329498
RPS29 ribosomal protein S29 -0.0328205
INHBA inhibin, beta A -0.0325882
STC1 stanniocalcin 1 -0.0320902
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0320192
RPS13 ribosomal protein S13 -0.0319562
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0319117
RPS25 ribosomal protein S25 -0.0318418
RGS2 regulator of G-protein signaling 2 -0.0317409
OASL 2'-5'-oligoadenylate synthetase-like -0.0314768
S100A10 S100 calcium binding protein A10 -0.0308343
TBXT T-box transcription factor T -0.030704
RACK1 receptor for activated C kinase 1 -0.0306804
BZW1 basic leucine zipper and W2 domains 1 -0.0305488
RPS17 ribosomal protein S17 -0.0303577
RPL11 ribosomal protein L11 -0.0300848
RPL36 ribosomal protein L36 -0.0300701
RPL35 ribosomal protein L35 -0.0293404
P3H2 prolyl 3-hydroxylase 2 -0.029257
GNAS GNAS complex locus -0.0292031
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0289998
PGK1 phosphoglycerate kinase 1 -0.028625
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0280063
LSAMP limbic system-associated membrane protein -0.0278998
TFPI2 tissue factor pathway inhibitor 2 -0.0272929
TMX4 thioredoxin-related transmembrane protein 4 -0.0266843
TMSB4X thymosin beta 4, X-linked -0.0258022
PRSS23 protease, serine, 23 -0.0257156
EIF1 eukaryotic translation initiation factor 1 -0.0236184
UNC5D unc-5 homolog D (C. elegans) -0.0234167
TENM3 teneurin transmembrane protein 3 -0.0233994
UBC ubiquitin C -0.0233366
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0231772
TGFBI transforming growth factor, beta-induced, 68kDa -0.0227473
FOXC1 forkhead box C1 -0.0226123
KIAA0825 KIAA0825 -0.0224413
RPL32 ribosomal protein L32 -0.0223945
TPM4 tropomyosin 4 -0.0217976
SRGN serglycin -0.0216196
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0213194
CCDC68 coiled-coil domain containing 68 -0.0212594
RPS11 ribosomal protein S11 -0.0208853
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0208614
KPNB1 karyopherin (importin) beta 1 -0.0208
ASTN2 astrotactin 2 -0.0202696