Acetohexamide_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0573315
FLNB filamin B, beta 0.0535372
ZNF292 zinc finger protein 292 0.0515781
PDE4D phosphodiesterase 4D, cAMP-specific 0.0446978
DSCAM Down syndrome cell adhesion molecule 0.0432407
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0428155
ADAM10 ADAM metallopeptidase domain 10 0.0394787
HDAC9 histone deacetylase 9 0.0387233
RTN4 reticulon 4 0.0368654
NBAS neuroblastoma amplified sequence 0.0334791
GOLGA4 golgin A4 0.0326196
TXNRD1 thioredoxin reductase 1 0.0322703
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0321015
ANK2 ankyrin 2, neuronal 0.0309716
PICALM phosphatidylinositol binding clathrin assembly protein 0.0305124
NUP58 nucleoporin 58 0.0293371
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.028896
PTBP2 polypyrimidine tract binding protein 2 0.0284373
TMEM65 transmembrane protein 65 0.028144
NAMPT nicotinamide phosphoribosyltransferase 0.0281383
RBM39 RNA binding motif protein 39 0.0267633
ZNF608 zinc finger protein 608 0.0253086
RNF145 ring finger protein 145 0.0243683
COG5 component of oligomeric golgi complex 5 0.0241107
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0241005
TXNIP thioredoxin interacting protein 0.0239539
ZCCHC7 zinc finger, CCHC domain containing 7 0.0239375
MON2 MON2 homolog (S. cerevisiae) 0.0238481
ADAM9 ADAM metallopeptidase domain 9 0.0236776
UBA6 ubiquitin-like modifier activating enzyme 6 0.0236189
CCNL1 cyclin L1 0.0235799
GARS1 glycyl-tRNA synthetase 1 0.0233178
SREBF2 sterol regulatory element binding transcription factor 2 0.0230099
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0229013
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0227888
USP34 ubiquitin specific peptidase 34 0.0221934
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0219294
FNDC3B fibronectin type III domain containing 3B 0.021927
TGFBR3 transforming growth factor, beta receptor III 0.0218443
ECT2 epithelial cell transforming 2 0.0209447
SBF2 SET binding factor 2 0.0207003
NCKAP1 NCK-associated protein 1 0.0206255
TFG TRK-fused gene 0.0206195
EML4 echinoderm microtubule associated protein like 4 0.0204232
SAMD4A sterile alpha motif domain containing 4A 0.0203473
QKI QKI, KH domain containing, RNA binding 0.0200523
USP3 ubiquitin specific peptidase 3 0.0199262
ZMYM2 zinc finger, MYM-type 2 0.019676
BRWD1 bromodomain and WD repeat domain containing 1 0.019528
YAP1 Yes-associated protein 1 0.0192836
KDM3A lysine (K)-specific demethylase 3A 0.0192286
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0191565
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0191217
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0190767
HELZ helicase with zinc finger 0.0190759
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0190464
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0188485
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0188405
CDC73 cell division cycle 73 0.0187969
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0186239
SMYD3 SET and MYND domain containing 3 0.0184663
MBD5 methyl-CpG binding domain protein 5 0.0183169
BIRC6 baculoviral IAP repeat containing 6 0.0182076
TBC1D5 TBC1 domain family, member 5 0.0180453
GSK3B glycogen synthase kinase 3 beta 0.0180276
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0179814
RUSC2 RUN and SH3 domain containing 2 0.0179129
SPRED2 sprouty-related, EVH1 domain containing 2 0.0177779
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0177601
TMEM41B transmembrane protein 41B 0.0175095
WAC WW domain containing adaptor with coiled-coil 0.0174207
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0172694
SEC23A Sec23 homolog A (S. cerevisiae) 0.0171869
AHCYL2 adenosylhomocysteinase-like 2 0.0171034
USP24 ubiquitin specific peptidase 24 0.0170824
STRN3 striatin, calmodulin binding protein 3 0.0169515
PYGB phosphorylase, glycogen; brain 0.0168602
TLK1 tousled-like kinase 1 0.0167539
KMT2C lysine (K)-specific methyltransferase 2C 0.0167348
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0167211
NKTR natural killer cell triggering receptor 0.0166033
FXR1 fragile X mental retardation, autosomal homolog 1 0.0165898
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0165035
ZBTB20 zinc finger and BTB domain containing 20 0.0164935
METTL15 methyltransferase like 15 0.0163642
KMT2E lysine (K)-specific methyltransferase 2E 0.0162011
PNISR PNN-interacting serine/arginine-rich protein 0.0161951
ZFC3H1 zinc finger, C3H1-type containing 0.0161811
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0161274
KDM6A lysine (K)-specific demethylase 6A 0.0160948
WDR43 WD repeat domain 43 0.0159877
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0159211
TNRC6A trinucleotide repeat containing 6A 0.0158867
MED13L mediator complex subunit 13-like 0.0158237
ZFAND3 zinc finger, AN1-type domain 3 0.015639
BTBD9 BTB (POZ) domain containing 9 0.0155073
AZIN1 antizyme inhibitor 1 0.0153633
YEATS2 YEATS domain containing 2 0.0153027
FAM13A family with sequence similarity 13, member A 0.0151659
RHBDD1 rhomboid domain containing 1 0.0151342

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.365584
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.229428
RPS6 ribosomal protein S6 -0.130622
RPS8 ribosomal protein S8 -0.124871
AHNAK AHNAK nucleoprotein -0.112731
BMP10 bone morphogenetic protein 10 -0.111909
TPT1 tumor protein, translationally-controlled 1 -0.110606
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.103423
CPED1 cadherin-like and PC-esterase domain containing 1 -0.077976
RPL35A ribosomal protein L35a -0.0759932
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0758907
TMSB4X thymosin beta 4, X-linked -0.0752041
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0731594
RPLP1 ribosomal protein, large, P1 -0.0703082
PDE4B phosphodiesterase 4B, cAMP-specific -0.0692166
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.068394
ACTG1 actin gamma 1 -0.0674851
RPL34 ribosomal protein L34 -0.0673573
RPL31 ribosomal protein L31 -0.0668062
ENO1 enolase 1, (alpha) -0.0630646
ARL4C ADP-ribosylation factor-like 4C -0.0590604
RPL12 ribosomal protein L12 -0.0590503
RPL19 ribosomal protein L19 -0.0582367
RPL37A ribosomal protein L37a -0.0554788
MKI67 marker of proliferation Ki-67 -0.0551972
RPS19 ribosomal protein S19 -0.0535459
CCND1 cyclin D1 -0.0532025
RPL23 ribosomal protein L23 -0.0529194
HSPB1 heat shock 27kDa protein 1 -0.051965
RPS13 ribosomal protein S13 -0.0514686
RPL26 ribosomal protein L26 -0.0513916
RPLP2 ribosomal protein, large, P2 -0.0507065
VCL vinculin -0.0504332
DLG1 discs, large homolog 1 (Drosophila) -0.0501462
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0491541
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0483088
FOXP1 forkhead box P1 -0.0482924
TM4SF1 transmembrane 4 L six family member 1 -0.0468649
EBNA1BP2 EBNA1 binding protein 2 -0.0455337
RPS3 ribosomal protein S3 -0.0450862
PKM pyruvate kinase, muscle -0.0449146
RPL9 ribosomal protein L9 -0.0444489
RPS23 ribosomal protein S23 -0.0442838
RPS25 ribosomal protein S25 -0.0441658
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0428804
RPL7A ribosomal protein L7a -0.0427317
RPS24 ribosomal protein S24 -0.0418199
RPL11 ribosomal protein L11 -0.0412072
RPS27A ribosomal protein S27a -0.040557
RPS21 ribosomal protein S21 -0.040034
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0394018
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0393061
NAP1L1 nucleosome assembly protein 1-like 1 -0.0389441
ANXA1 annexin A1 -0.0386777
RPS12 ribosomal protein S12 -0.0368676
TMSB10 thymosin beta 10 -0.0367112
TPM4 tropomyosin 4 -0.0356171
RACK1 receptor for activated C kinase 1 -0.0355646
RPLP0 ribosomal protein, large, P0 -0.0353527
S100A4 S100 calcium binding protein A4 -0.0352537
RPL36 ribosomal protein L36 -0.0352135
RPS16 ribosomal protein S16 -0.0342928
RPL32 ribosomal protein L32 -0.034203
RPL8 ribosomal protein L8 -0.0339331
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0338708
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0337019
TPI1 triosephosphate isomerase 1 -0.0330647
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0329191
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0327433
RPL18 ribosomal protein L18 -0.0327289
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0325231
RPL36A ribosomal protein L36a -0.0316165
KPNB1 karyopherin (importin) beta 1 -0.0315992
RPS14 ribosomal protein S14 -0.0314904
UNC13A unc-13 homolog A (C. elegans) -0.0314325
RPS17 ribosomal protein S17 -0.0313154
S100A9 S100 calcium binding protein A9 -0.0312695
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0310313
S100A10 S100 calcium binding protein A10 -0.0310258
CAMKMT calmodulin-lysine N-methyltransferase -0.0308426
RPL5 ribosomal protein L5 -0.0306873
RPS11 ribosomal protein S11 -0.030288
RPL10A ribosomal protein L10a -0.0302743
NPAS2 neuronal PAS domain protein 2 -0.0301925
RPS10 ribosomal protein S10 -0.0301588
MYL12B myosin, light chain 12B, regulatory -0.0295474
LOC102724023 ES1 protein homolog, mitochondrial -0.0283477
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0283049
B2M beta-2-microglobulin -0.0282977
RPS29 ribosomal protein S29 -0.0282011
RPL37 ribosomal protein L37 -0.0281106
TUBA1B tubulin, alpha 1b -0.0280206
RPL35 ribosomal protein L35 -0.0279225
DIAPH3 diaphanous-related formin 3 -0.027882
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0275635
CENPF centromere protein F, 350/400kDa -0.0271765
RSL1D1 ribosomal L1 domain containing 1 -0.0269755
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0264954
ZMYND8 zinc finger, MYND-type containing 8 -0.0264714
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0264251