Acetohexamide_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.263854
ZSWIM6 zinc finger, SWIM-type containing 6 0.0964923
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0738782
MACF1 microtubule-actin crosslinking factor 1 0.0701817
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.067484
FMNL2 formin-like 2 0.0615301
DST dystonin 0.0613676
BIRC3 baculoviral IAP repeat containing 3 0.0552919
PRKCA protein kinase C, alpha 0.0552495
FNDC3B fibronectin type III domain containing 3B 0.0544048
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0514385
ATXN1 ataxin 1 0.0510943
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.050944
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0496471
HMGA2 high mobility group AT-hook 2 0.0473797
SLC38A2 solute carrier family 38, member 2 0.0461311
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0456309
SAMD4A sterile alpha motif domain containing 4A 0.0455563
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0442643
SQSTM1 sequestosome 1 0.0439003
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0437665
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0437663
INTS6 integrator complex subunit 6 0.0434905
MBNL1 muscleblind-like splicing regulator 1 0.0395361
RUNX1 runt-related transcription factor 1 0.0392309
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.038392
ANXA2 annexin A2 0.0378924
FTH1 ferritin, heavy polypeptide 1 0.037882
MBNL2 muscleblind-like splicing regulator 2 0.0373642
NT5E 5'-nucleotidase, ecto (CD73) 0.0357151
VIM vimentin 0.0355632
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0354597
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0354512
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0348075
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0342414
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0332747
ANXA1 annexin A1 0.03266
AKAP12 A kinase (PRKA) anchor protein 12 0.0325579
LPP LIM domain containing preferred translocation partner in lipoma 0.0320741
DENND4A DENN/MADD domain containing 4A 0.0320292
WNK1 WNK lysine deficient protein kinase 1 0.0319058
IQGAP1 IQ motif containing GTPase activating protein 1 0.0311071
CSNK1A1 casein kinase 1, alpha 1 0.0310007
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0302253
TRIO trio Rho guanine nucleotide exchange factor 0.0298905
IL1RAP interleukin 1 receptor accessory protein 0.0287455
ANO6 anoctamin 6 0.0285546
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0282105
POTEF POTE ankyrin domain family, member F 0.027826
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0278213
MYH9 myosin, heavy chain 9, non-muscle 0.0276766
BICD1 bicaudal D homolog 1 (Drosophila) 0.0276416
KIF5B kinesin family member 5B 0.0275344
PKM pyruvate kinase, muscle 0.026714
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0266559
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.026522
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0264813
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0261637
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0258438
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0258309
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0253297
SVIL supervillin 0.0252704
SPAG9 sperm associated antigen 9 0.0252667
SATB2 SATB homeobox 2 0.0251433
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0250652
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0247927
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0245717
UTRN utrophin 0.0245266
GOLGB1 golgin B1 0.0243916
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0242579
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0240659
DTNA dystrobrevin, alpha 0.0238335
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0236943
GOLGA4 golgin A4 0.0234585
IRAK2 interleukin-1 receptor-associated kinase 2 0.023384
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0230822
YBX3 Y box binding protein 3 0.0228873
COL5A1 collagen, type V, alpha 1 0.0226804
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0225626
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0224399
CD44 CD44 molecule (Indian blood group) 0.022438
ITCH itchy E3 ubiquitin protein ligase 0.0222649
JMJD1C jumonji domain containing 1C 0.0221832
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0221386
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0220886
NPAS2 neuronal PAS domain protein 2 0.0218791
OXSR1 oxidative stress responsive 1 0.0217484
CLIC4 chloride intracellular channel 4 0.0216576
KDM2A lysine (K)-specific demethylase 2A 0.0215897
UBC ubiquitin C 0.0212693
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0212308
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0212006
SEC31A SEC31 homolog A (S. cerevisiae) 0.0211994
OSBPL8 oxysterol binding protein-like 8 0.0211733
EPAS1 endothelial PAS domain protein 1 0.0210707
RIGI RNA sensor RIG-I 0.0208257
ZFAND3 zinc finger, AN1-type domain 3 0.0208006
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0205935
EGFR epidermal growth factor receptor 0.0205162
ARL15 ADP-ribosylation factor-like 15 0.0204612

decreased expression

Symbol Name Standardized Value
TAS2R14 taste receptor, type 2, member 14 -0.0229789
GPC6 glypican 6 -0.0229765
BZW1 basic leucine zipper and W2 domains 1 -0.0223601
FBXL2 F-box and leucine-rich repeat protein 2 -0.0222272
ACER3 alkaline ceramidase 3 -0.0209648
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0206754
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0199329
ANKRD12 ankyrin repeat domain 12 -0.0186483
TCERG1 transcription elongation regulator 1 -0.0179898
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0174977
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0172259
KIAA1328 KIAA1328 -0.0171027
TGFBR1 transforming growth factor, beta receptor 1 -0.0155006
GOLT1B golgi transport 1B -0.0154828
DLG1 discs, large homolog 1 (Drosophila) -0.0153664
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.015026
SAR1A secretion associated, Ras related GTPase 1A -0.0148504
KIF4A kinesin family member 4A -0.0148254
GOSR1 golgi SNAP receptor complex member 1 -0.0146027
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0145537
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0144128
YEATS2 YEATS domain containing 2 -0.0143824
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0143422
LDHA lactate dehydrogenase A -0.0142546
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0141725
THSD4 thrombospondin, type I, domain containing 4 -0.0140665
TP53 tumor protein p53 -0.0138599
ZNF267 zinc finger protein 267 -0.0135516
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0135168
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0132855
RAD21 RAD21 homolog (S. pombe) -0.013276
TXN2 thioredoxin 2 -0.0132751
ATXN3 ataxin 3 -0.013254
THOC2 THO complex 2 -0.0131452
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0131007
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -0.0130399
FBXO34 F-box protein 34 -0.0130212
NOP58 NOP58 ribonucleoprotein -0.0129205
TLE5 TLE family member 5, transcriptional modulator -0.0127333
FUBP3 far upstream element (FUSE) binding protein 3 -0.0126836
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0126234
RPS27A ribosomal protein S27a -0.0126016
NUP98 nucleoporin 98kDa -0.0125944
ANO10 anoctamin 10 -0.0125732
ARMC1 armadillo repeat containing 1 -0.0125461
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0124995
SRPK1 SRSF protein kinase 1 -0.0124696
MON2 MON2 homolog (S. cerevisiae) -0.0123931
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0123891
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0123579
TUBB6 tubulin, beta 6 class V -0.0123393
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.0123173
BIRC2 baculoviral IAP repeat containing 2 -0.0122862
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.0122836
FASTKD2 FAST kinase domains 2 -0.0122733
HDLBP high density lipoprotein binding protein -0.012171
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0120923
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0120756
SKIC3 SKI3 subunit of superkiller complex -0.0120036
CREBBP CREB binding protein -0.0119803
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0119656
BTG1 B-cell translocation gene 1, anti-proliferative -0.0119442
TM9SF3 transmembrane 9 superfamily member 3 -0.0118229
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0118189
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0117975
ATAD2 ATPase family, AAA domain containing 2 -0.0117582
ILK integrin-linked kinase -0.0117569
SMC4 structural maintenance of chromosomes 4 -0.0116544
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0115729
FANCI Fanconi anemia, complementation group I -0.0115651
SP3 Sp3 transcription factor -0.0115616
TPM4 tropomyosin 4 -0.0115122
RPL35A ribosomal protein L35a -0.0114839
CENPK centromere protein K -0.011472
TNPO1 transportin 1 -0.0114321
FANCL Fanconi anemia, complementation group L -0.011415
PDCD10 programmed cell death 10 -0.0113842
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0113703
ZNF717 zinc finger protein 717 -0.0113291
MARCHF6 membrane associated ring-CH-type finger 6 -0.0113033
FPGS folylpolyglutamate synthase -0.0112673
KIF13A kinesin family member 13A -0.0112657
RNF169 ring finger protein 169 -0.0112344
NCOA1 nuclear receptor coactivator 1 -0.0111678
COG5 component of oligomeric golgi complex 5 -0.0111311
NCAPD3 non-SMC condensin II complex, subunit D3 -0.0110946
PPA2 pyrophosphatase (inorganic) 2 -0.0110853
ICA1 islet cell autoantigen 1, 69kDa -0.0110663
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0110655
NEK7 NIMA-related kinase 7 -0.0109945
TMEM87A transmembrane protein 87A -0.0109705
FANCC Fanconi anemia, complementation group C -0.0108742
KIF3A kinesin family member 3A -0.0108496
COX20 COX20 cytochrome c oxidase assembly factor -0.0107564
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 -0.0107413
SCAF11 SR-related CTD-associated factor 11 -0.0105939
STRN3 striatin, calmodulin binding protein 3 -0.0105937
WDPCP WD repeat containing planar cell polarity effector -0.0105138
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0104255
NUP54 nucleoporin 54kDa -0.0104115