Acetohexamide_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Acetohexamide perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Acetohexamide_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.105545
CXCL8 chemokine (C-X-C motif) ligand 8 0.0979223
ZSWIM6 zinc finger, SWIM-type containing 6 0.0682415
NDRG1 N-myc downstream regulated 1 0.0669501
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0592585
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0580522
FTH1 ferritin, heavy polypeptide 1 0.0552344
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0521566
FAM13A family with sequence similarity 13, member A 0.0502982
RNF145 ring finger protein 145 0.0482652
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0467832
HILPDA hypoxia inducible lipid droplet-associated 0.0453046
AKAP12 A kinase (PRKA) anchor protein 12 0.0426675
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0412146
RICTOR RPTOR independent companion of MTOR, complex 2 0.0385436
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0361633
STC2 stanniocalcin 2 0.0355383
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0351196
GRB10 growth factor receptor-bound protein 10 0.0331173
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0325668
LMNA lamin A/C 0.0318303
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0312111
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0310212
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0297848
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.029631
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0293166
VEGFA vascular endothelial growth factor A 0.0292332
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0292154
INTS6 integrator complex subunit 6 0.0287641
MBNL1 muscleblind-like splicing regulator 1 0.0282867
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0281786
HMGA2 high mobility group AT-hook 2 0.0279632
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0279221
PTK2 protein tyrosine kinase 2 0.0275394
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0267607
SOX9 SRY (sex determining region Y)-box 9 0.0262969
APLP2 amyloid beta (A4) precursor-like protein 2 0.0259595
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0258799
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0256931
DUSP10 dual specificity phosphatase 10 0.0255134
EPS8 epidermal growth factor receptor pathway substrate 8 0.0250597
FXR1 fragile X mental retardation, autosomal homolog 1 0.024357
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0242494
CTBP2 C-terminal binding protein 2 0.0240827
SMAD3 SMAD family member 3 0.0239066
RASAL2 RAS protein activator like 2 0.0236637
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.023084
FOSL1 FOS-like antigen 1 0.0230341
TCIM transcriptional and immune response regulator 0.0225334
RYBP RING1 and YY1 binding protein 0.0225294
NPTN neuroplastin 0.0222131
ERRFI1 ERBB receptor feedback inhibitor 1 0.0219319
SUCO SUN domain containing ossification factor 0.0217666
AKAP13 A kinase (PRKA) anchor protein 13 0.0216089
RAB8B RAB8B, member RAS oncogene family 0.0215541
TTC3 tetratricopeptide repeat domain 3 0.0214954
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0214204
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0213814
MYOF myoferlin 0.0211024
SLC35F3 solute carrier family 35, member F3 0.0210618
LYST lysosomal trafficking regulator 0.0209572
RPL28 ribosomal protein L28 0.020911
FMNL2 formin-like 2 0.0208898
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0208406
LOXL2 lysyl oxidase-like 2 0.0208402
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0205624
SSBP2 single-stranded DNA binding protein 2 0.0205318
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0205238
FBXO11 F-box protein 11 0.0204466
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0203531
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0201618
MYADM myeloid-associated differentiation marker 0.0201396
SHB Src homology 2 domain containing adaptor protein B 0.0200591
LIMCH1 LIM and calponin homology domains 1 0.0198042
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0196875
MCL1 myeloid cell leukemia 1 0.0194052
ATF3 activating transcription factor 3 0.0194025
FAT1 FAT atypical cadherin 1 0.0191249
SAMD4A sterile alpha motif domain containing 4A 0.0189941
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0189855
FLNB filamin B, beta 0.0188784
RND3 Rho family GTPase 3 0.0187617
SGMS2 sphingomyelin synthase 2 0.0185489
CADM1 cell adhesion molecule 1 0.018503
EXT1 exostosin glycosyltransferase 1 0.0182875
JUN jun proto-oncogene 0.018196
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0181035
BHLHE40 basic helix-loop-helix family, member e40 0.0179621
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.017851
MTMR3 myotubularin related protein 3 0.0176327
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0176023
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0175655
ELL2 elongation factor, RNA polymerase II, 2 0.0175441
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0173493
MRTFA myocardin related transcription factor A 0.0173483
IRS2 insulin receptor substrate 2 0.0173201
PELI1 pellino E3 ubiquitin protein ligase 1 0.017303
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0172914
DNM1L dynamin 1-like 0.0172893
FERMT2 fermitin family member 2 0.0172785

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.280551
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.218036
FN1 fibronectin 1 -0.130013
OSMR oncostatin M receptor -0.087405
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0780899
PTMA prothymosin, alpha -0.0650688
HLA-B major histocompatibility complex, class I, B -0.0649055
ITGA1 integrin, alpha 1 -0.0642242
SQSTM1 sequestosome 1 -0.0617256
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0589155
VIM vimentin -0.0535297
TPT1 tumor protein, translationally-controlled 1 -0.0471541
NAMPT nicotinamide phosphoribosyltransferase -0.0466302
TMSB10 thymosin beta 10 -0.0459338
NRP1 neuropilin 1 -0.0450676
IFI16 interferon, gamma-inducible protein 16 -0.0443076
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0420393
ZMYND8 zinc finger, MYND-type containing 8 -0.0418714
CANX calnexin -0.0415081
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0412003
ETV1 ets variant 1 -0.0409131
SMOX spermine oxidase -0.0392935
RRBP1 ribosome binding protein 1 -0.0381946
SYT1 synaptotagmin I -0.0377796
GLIS3 GLIS family zinc finger 3 -0.0352661
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0351938
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0342681
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.03378
MBD5 methyl-CpG binding domain protein 5 -0.0329275
ETV6 ets variant 6 -0.0328057
FAF2 Fas associated factor family member 2 -0.0325928
S100A6 S100 calcium binding protein A6 -0.0318311
NPC1 Niemann-Pick disease, type C1 -0.0315218
OGA O-GlcNAcase -0.0313872
FOXP1 forkhead box P1 -0.0309308
SOS1 son of sevenless homolog 1 (Drosophila) -0.0302367
TOP1 topoisomerase (DNA) I -0.0295438
RTN4 reticulon 4 -0.0292398
RPL35A ribosomal protein L35a -0.0292319
RPS24 ribosomal protein S24 -0.0285754
TMEM165 transmembrane protein 165 -0.0285709
ADD3 adducin 3 (gamma) -0.0281496
TPM4 tropomyosin 4 -0.0276494
PELO pelota homolog (Drosophila) -0.0269993
FAM20C family with sequence similarity 20, member C -0.0269694
TMSB4X thymosin beta 4, X-linked -0.0265932
RPS6 ribosomal protein S6 -0.0262519
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0259788
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0258397
EFNA5 ephrin-A5 -0.0255032
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0253307
NIPBL Nipped-B homolog (Drosophila) -0.0250014
SOX4 SRY (sex determining region Y)-box 4 -0.0249619
TAS2R14 taste receptor, type 2, member 14 -0.0249179
ZBTB20 zinc finger and BTB domain containing 20 -0.0245613
MCTP2 multiple C2 domains, transmembrane 2 -0.0244938
TM9SF3 transmembrane 9 superfamily member 3 -0.024461
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.024117
CAB39 calcium binding protein 39 -0.0239589
IFI27 interferon, alpha-inducible protein 27 -0.0239004
KLHL5 kelch-like family member 5 -0.02374
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0235267
RPL9 ribosomal protein L9 -0.0233436
IER3 immediate early response 3 -0.0229774
ACBD3 acyl-CoA binding domain containing 3 -0.0227422
PDE4D phosphodiesterase 4D, cAMP-specific -0.0223969
RPLP0 ribosomal protein, large, P0 -0.0223806
TPR translocated promoter region, nuclear basket protein -0.0221272
MT2A metallothionein 2A -0.0218974
ACTG1 actin gamma 1 -0.0218866
CDCP1 CUB domain containing protein 1 -0.0217791
AOPEP aminopeptidase O (putative) -0.0213368
FTL ferritin, light polypeptide -0.0211467
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.021008
GCC2 GRIP and coiled-coil domain containing 2 -0.0210032
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0206224
RPLP2 ribosomal protein, large, P2 -0.0203738
MKI67 marker of proliferation Ki-67 -0.0201664
HPCAL1 hippocalcin-like 1 -0.0201096
IL6ST interleukin 6 signal transducer -0.0200911
CDC27 cell division cycle 27 -0.0199066
FRY furry homolog (Drosophila) -0.0196633
RPL23 ribosomal protein L23 -0.0195677
RBM47 RNA binding motif protein 47 -0.0194594
RPL37A ribosomal protein L37a -0.0192937
RPL34 ribosomal protein L34 -0.0192252
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0191667
RUNX2 runt-related transcription factor 2 -0.0189477
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0188482
TMEM131 transmembrane protein 131 -0.0188116
CD44 CD44 molecule (Indian blood group) -0.0186262
BPTF bromodomain PHD finger transcription factor -0.0185142
EPN2 epsin 2 -0.0184976
AHR aryl hydrocarbon receptor -0.0184488
WDR26 WD repeat domain 26 -0.0183605
HDLBP high density lipoprotein binding protein -0.0183015
ITGB5 integrin, beta 5 -0.0181857
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0181535
DLG1 discs, large homolog 1 (Drosophila) -0.0180421
RPL12 ribosomal protein L12 -0.0179389