| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5284513 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Acitretin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 1.73 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 1.7 |
| GGT1 | gamma-glutamyltransferase 1 | 1.5 |
| ANGPTL4 | angiopoietin-like 4 | 0.89 |
| SLC25A16 | solute carrier family 25 (mitochondrial carrier), member 16 | 0.83 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.83 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.75 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.72 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.68 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.56 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.54 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.53 |
| CCNF | cyclin F | 0.52 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.5 |
| POMP | proteasome maturation protein | 0.49 |
| HAS3 | hyaluronan synthase 3 | 0.49 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | 0.49 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.48 |
| SERAC1 | serine active site containing 1 | 0.48 |
| KLHL22 | kelch-like family member 22 | 0.48 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | 0.47 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 0.46 |
| SMAD3 | SMAD family member 3 | 0.46 |
| TMEM135 | transmembrane protein 135 | 0.46 |
| CCDC9B | coiled-coil domain containing 9B | 0.45 |
| KLK6 | kallikrein-related peptidase 6 | 0.45 |
| YDJC | YdjC homolog (bacterial) | 0.44 |
| FZD1 | frizzled class receptor 1 | 0.43 |
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.43 |
| FN1 | fibronectin 1 | 0.41 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.41 |
| DECR2 | 2,4-dienoyl CoA reductase 2, peroxisomal | 0.4 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.4 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.4 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.4 |
| S100A5 | S100 calcium binding protein A5 | 0.39 |
| PFDN1 | prefoldin subunit 1 | 0.39 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.39 |
| SGMS1 | sphingomyelin synthase 1 | 0.39 |
| YAP1 | Yes-associated protein 1 | 0.39 |
| PRKD1 | protein kinase D1 | 0.38 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.38 |
| ADIPOR1 | adiponectin receptor 1 | 0.37 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.37 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.36 |
| ABHD18 | abhydrolase domain containing 18 | 0.36 |
| SRI | sorcin | 0.36 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.36 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | 0.35 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.35 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.35 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.35 |
| PEX19 | peroxisomal biogenesis factor 19 | 0.34 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | 0.34 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.34 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.34 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.34 |
| TPM4 | tropomyosin 4 | 0.34 |
| SLC66A2 | solute carrier family 66 member 2 | 0.34 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.34 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.34 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.33 |
| TRIM29 | tripartite motif containing 29 | 0.33 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.33 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 0.32 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.32 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | 0.32 |
| NOVA2 | neuro-oncological ventral antigen 2 | 0.32 |
| TMEM87B | transmembrane protein 87B | 0.32 |
| CNTNAP3 | contactin associated protein-like 3 | 0.32 |
| AGFG2 | ArfGAP with FG repeats 2 | 0.32 |
| LMO4 | LIM domain only 4 | 0.32 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.31 |
| ANKS3 | ankyrin repeat and sterile alpha motif domain containing 3 | 0.31 |
| ZNF263 | zinc finger protein 263 | 0.31 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 0.31 |
| PROS1 | protein S (alpha) | 0.31 |
| ADIRF | adipogenesis regulatory factor | 0.31 |
| PEX5 | peroxisomal biogenesis factor 5 | 0.31 |
| FDX1 | ferredoxin 1 | 0.31 |
| RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) | 0.31 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.31 |
| STEAP2 | STEAP family member 2, metalloreductase | 0.31 |
| MYO15A | myosin XVA | 0.3 |
| MXRA7 | matrix-remodelling associated 7 | 0.3 |
| CHPF | chondroitin polymerizing factor | 0.3 |
| WNT16 | wingless-type MMTV integration site family, member 16 | 0.3 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | 0.3 |
| SYTL3 | synaptotagmin-like 3 | 0.3 |
| WSB2 | WD repeat and SOCS box containing 2 | 0.3 |
| TMEM189 | transmembrane protein 189 | 0.3 |
| SEMG2 | semenogelin II | 0.3 |
| ATP9A | ATPase, class II, type 9A | 0.3 |
| FAR1 | fatty acyl CoA reductase 1 | 0.29 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.29 |
| FLNB | filamin B, beta | 0.29 |
| MISP3 | MISP family member 3 | 0.29 |
| NENF | neudesin neurotrophic factor | 0.29 |
| FAM174A | family with sequence similarity 174, member A | 0.29 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KSR2 | kinase suppressor of ras 2 | -1.18 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -1.08 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -0.97 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.93 |
| GSTM4 | glutathione S-transferase mu 4 | -0.88 |
| IFI35 | interferon-induced protein 35 | -0.67 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.66 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.65 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.64 |
| PHF1 | PHD finger protein 1 | -0.63 |
| EPHA4 | EPH receptor A4 | -0.62 |
| BCOR | BCL6 corepressor | -0.59 |
| CCDC150 | coiled-coil domain containing 150 | -0.56 |
| TPM1 | tropomyosin 1 (alpha) | -0.56 |
| PLPP6 | phospholipid phosphatase 6 | -0.55 |
| ANKRD36 | ankyrin repeat domain 36 | -0.54 |
| SP140 | SP140 nuclear body protein | -0.53 |
| TNNI3K | TNNI3 interacting kinase | -0.53 |
| ABHD2 | abhydrolase domain containing 2 | -0.53 |
| HBS1L | HBS1-like translational GTPase | -0.52 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.5 |
| BPGM | 2,3-bisphosphoglycerate mutase | -0.47 |
| BAIAP3 | BAI1-associated protein 3 | -0.44 |
| VGF | VGF nerve growth factor inducible | -0.44 |
| SESN2 | sestrin 2 | -0.43 |
| TMEM184B | transmembrane protein 184B | -0.42 |
| PYGM | phosphorylase, glycogen, muscle | -0.42 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.42 |
| ZIC5 | Zic family member 5 | -0.42 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | -0.41 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | -0.41 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.41 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | -0.4 |
| UNC13D | unc-13 homolog D (C. elegans) | -0.4 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.39 |
| MON1A | MON1 secretory trafficking family member A | -0.39 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.39 |
| FBP2 | fructose-1,6-bisphosphatase 2 | -0.39 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | -0.39 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.38 |
| ATE1 | arginyltransferase 1 | -0.38 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.38 |
| SET | SET nuclear proto-oncogene | -0.37 |
| FAM20C | family with sequence similarity 20, member C | -0.37 |
| CYBRD1 | cytochrome b reductase 1 | -0.37 |
| ZNF696 | zinc finger protein 696 | -0.37 |
| SLC35B1 | solute carrier family 35, member B1 | -0.36 |
| SYN1 | synapsin I | -0.36 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | -0.36 |
| CALU | calumenin | -0.36 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.35 |
| TRAF3 | TNF receptor-associated factor 3 | -0.35 |
| INHBA | inhibin, beta A | -0.35 |
| TGFB1 | transforming growth factor, beta 1 | -0.34 |
| SIDT2 | SID1 transmembrane family, member 2 | -0.34 |
| GPR180 | G protein-coupled receptor 180 | -0.33 |
| MYH4 | myosin, heavy chain 4, skeletal muscle | -0.33 |
| RMI2 | RecQ mediated genome instability 2 | -0.33 |
| HOXB9 | homeobox B9 | -0.32 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.31 |
| PIWIL2 | piwi-like RNA-mediated gene silencing 2 | -0.31 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.31 |
| TIGD5 | tigger transposable element derived 5 | -0.31 |
| SNAP91 | synaptosomal-associated protein, 91kDa | -0.31 |
| ELMO1 | engulfment and cell motility 1 | -0.31 |
| SRXN1 | sulfiredoxin 1 | -0.3 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.3 |
| STARD9 | StAR-related lipid transfer (START) domain containing 9 | -0.3 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.3 |
| ZFP62 | ZFP62 zinc finger protein | -0.3 |
| LIN7A | lin-7 homolog A (C. elegans) | -0.3 |
| RPAIN | RPA interacting protein | -0.3 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.3 |
| TEP1 | telomerase-associated protein 1 | -0.29 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.29 |
| ZNF561 | zinc finger protein 561 | -0.29 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.29 |
| ZNF669 | zinc finger protein 669 | -0.29 |
| ZNF791 | zinc finger protein 791 | -0.29 |
| MAGEA6 | melanoma antigen family A6 | -0.29 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.28 |
| DES | desmin | -0.28 |
| CYBC1 | cytochrome b-245 chaperone 1 | -0.28 |
| GAS6 | growth arrest-specific 6 | -0.28 |
| FAM241A | family with sequence similarity 241 member A | -0.28 |
| SNPH | syntaphilin | -0.27 |
| PAH | phenylalanine hydroxylase | -0.27 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.27 |
| SERINC1 | serine incorporator 1 | -0.27 |
| BRD9 | bromodomain containing 9 | -0.27 |
| DEAF1 | DEAF1 transcription factor | -0.27 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.27 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | -0.27 |
| CD58 | CD58 molecule | -0.26 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.26 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | -0.26 |
| FTL | ferritin, light polypeptide | -0.26 |
| KCTD6 | potassium channel tetramerization domain containing 6 | -0.26 |
| CHTF8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) | -0.26 |
