Acne Vulgaris Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors. (Experimental Factor Ontology, EFO_0003894)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D000152
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Genes

95 genes/proteins associated with the disease Acne Vulgaris from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.75201
VEGFA vascular endothelial growth factor A 1.72055
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.66253
PLAT plasminogen activator, tissue 1.59873
PROS1 protein S (alpha) 1.49711
CXCL8 chemokine (C-X-C motif) ligand 8 1.47296
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.46488
LHB luteinizing hormone beta polypeptide 1.44681
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.43455
CCL3 chemokine (C-C motif) ligand 3 1.43428
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.42401
F2 coagulation factor II (thrombin) 1.4076
MMP9 matrix metallopeptidase 9 1.3998
ALB albumin 1.39702
IL6 interleukin 6 1.38807
CCL2 chemokine (C-C motif) ligand 2 1.38213
FSHB follicle stimulating hormone, beta polypeptide 1.38015
AR androgen receptor 1.3793
TNF tumor necrosis factor 1.37761
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.35962
IL1B interleukin 1, beta 1.3314
PLG plasminogen 1.3231
FGG fibrinogen gamma chain 1.29626
IGF1 insulin-like growth factor 1 (somatomedin C) 1.29595
TGFB1 transforming growth factor, beta 1 1.27471
IGFBP3 insulin-like growth factor binding protein 3 1.26794
GREB1 growth regulation by estrogen in breast cancer 1 1.26607
TAGLN transgelin 1.25682
CRABP2 cellular retinoic acid binding protein 2 1.2456
TFRC transferrin receptor 1.22404
VCAM1 vascular cell adhesion molecule 1 1.22306
S100A8 S100 calcium binding protein A8 1.22242
IL10 interleukin 10 1.21727
RARA retinoic acid receptor, alpha 1.21695
GSTP1 glutathione S-transferase pi 1 1.21663
ACTA2 actin, alpha 2, smooth muscle, aorta 1.19146
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.18587
FOS FBJ murine osteosarcoma viral oncogene homolog 1.18159
MMP13 matrix metallopeptidase 13 1.17827
RXRG retinoid X receptor, gamma 1.17563
SOX9 SRY (sex determining region Y)-box 9 1.17563
MBNL1 muscleblind-like splicing regulator 1 1.16567
TF transferrin 1.16137
RBP1 retinol binding protein 1, cellular 1.15831
BCL2 B-cell CLL/lymphoma 2 1.1556
MMP3 matrix metallopeptidase 3 1.15526
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.15526
EGFR epidermal growth factor receptor 1.15492
DCN decorin 1.15089
PGR progesterone receptor 1.14954
ETFDH electron-transferring-flavoprotein dehydrogenase 1.14747
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.14473
FGB fibrinogen beta chain 1.13109
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 1.12014
FGA fibrinogen alpha chain 1.11843
TP53 tumor protein p53 1.11673
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.11606
CRP C-reactive protein, pentraxin-related 1.11186
CAT catalase 1.11151
SRGN serglycin 1.11151
MAPK3 mitogen-activated protein kinase 3 1.11081
MKI67 marker of proliferation Ki-67 1.10907
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.10838
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.10734
MAPK1 mitogen-activated protein kinase 1 1.10175
G6PD glucose-6-phosphate dehydrogenase 1.09751
IFITM1 interferon induced transmembrane protein 1 1.09332
MDK midkine (neurite growth-promoting factor 2) 1.09011
S100A9 S100 calcium binding protein A9 1.08833
CYCS cytochrome c, somatic 1.08337
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.07732
GCLC glutamate-cysteine ligase, catalytic subunit 1.07518
ODC1 ornithine decarboxylase 1 1.07482
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.07376
RARG retinoic acid receptor, gamma 1.07163
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 1.07093
IL2 interleukin 2 1.06152
MUC1 mucin 1, cell surface associated 1.05573
PRL prolactin 1.04501
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.03901
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.03122
PER1 period circadian clock 1 1.02933
NOS3 nitric oxide synthase 3 (endothelial cell) 1.02783
KPNA1 karyopherin alpha 1 (importin alpha 5) 1.02746
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.02671
IL4 interleukin 4 1.02634
MMP2 matrix metallopeptidase 2 1.02634
F10 coagulation factor X 1.02188
PROC protein C (inactivator of coagulation factors Va and VIIIa) 1.0204
NKX2-1 NK2 homeobox 1 1.0204
LCN2 lipocalin 2 1.01928
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.01776
GSR glutathione reductase 1.01361
CAV1 caveolin 1, caveolae protein, 22kDa 1.01174
CCL5 chemokine (C-C motif) ligand 5 1.01025