Acne Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors. (Experimental Factor Ontology, EFO_0003894)
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Genes

191 genes associated with the disease Acne in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
LYPLAL1 lysophospholipase-like 1 1.978
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.961
RNASEH2C ribonuclease H2, subunit C 1.961
KAT5 K(lysine) acetyltransferase 5 1.961
WNT10A wingless-type MMTV integration site family, member 10A 1.951
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.951
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 1.951
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 1.951
FEV FEV (ETS oncogene family) 1.951
WNT6 wingless-type MMTV integration site family, member 6 1.951
GDPGP1 GDP-D-glucose phosphorylase 1 1.908
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.908
NGRN neugrin, neurite outgrowth associated 1.908
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 1.908
CIB1 calcium and integrin binding 1 (calmyrin) 1.908
SIPA1 signal-induced proliferation-associated 1 1.892
PCNX3 pecanex 3 1.892
ANKRD55 ankyrin repeat domain 55 1.872
FGF10 fibroblast growth factor 10 1.835
CIITA class II, major histocompatibility complex, transactivator 1.829
DEXI Dexi homolog (mouse) 1.829
CLEC16A C-type lectin domain family 16, member A 1.829
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 1.818
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 1.818
MRPL49 mitochondrial ribosomal protein L49 1.818
ZNHIT2 zinc finger, HIT-type containing 2 1.818
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 1.818
SNX15 sorting nexin 15 1.818
ZFPL1 zinc finger protein-like 1 1.818
TM7SF2 transmembrane 7 superfamily member 2 1.818
SAC3D1 SAC3 domain containing 1 1.818
SYVN1 synovial apoptosis inhibitor 1, synoviolin 1.818
TMEM262 transmembrane protein 262 1.818
CDCA5 cell division cycle associated 5 1.818
KCNK7 potassium channel, two pore domain subfamily K, member 7 1.814
EHBP1L1 EH domain binding protein 1-like 1 1.814
FAM89B family with sequence similarity 89, member B 1.814
MAP3K11 mitogen-activated protein kinase kinase kinase 11 1.814
SCYL1 SCY1-like 1 (S. cerevisiae) 1.814
LTBP3 latent transforming growth factor beta binding protein 3 1.814
ZNRD2 zinc ribbon domain containing 2 1.814
DUSP16 dual specificity phosphatase 16 1.805
BORCS5 BLOC-1 related complex subunit 5 1.805
CAPN1 calpain 1, (mu/I) large subunit 1.757
SPDYC speedy/RINGO cell cycle regulator family member C 1.757
UBE2T ubiquitin-conjugating enzyme E2T 1.725
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 1.725
PPP1R12B protein phosphatase 1, regulatory subunit 12B 1.725
LAMC1 laminin, gamma 1 (formerly LAMB2) 1.724
LAMC2 laminin, gamma 2 1.724
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 1.724
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 1.722
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 1.651
SUGCT succinyl-CoA:glutarate-CoA transferase 1.623
MAJIN membrane anchored junction protein 1.605
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.586
SYN3 synapsin III 1.55
TIMP3 TIMP metallopeptidase inhibitor 3 1.55
FAM162A family with sequence similarity 162, member A 1.53
WDR5B WD repeat domain 5B 1.53
CASR calcium-sensing receptor 1.53
KPNA1 karyopherin alpha 1 (importin alpha 5) 1.53
CSTA cystatin A (stefin A) 1.53
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 1.528
BEST1 bestrophin 1 1.528
FADS3 fatty acid desaturase 3 1.528
FADS2 fatty acid desaturase 2 1.528
MYRF myelin regulatory factor 1.528
FEN1 flap structure-specific endonuclease 1 1.528
TMEM258 transmembrane protein 258 1.528
FADS1 fatty acid desaturase 1 1.528
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.505
IRF1 interferon regulatory factor 1 1.505
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 1.505
PDLIM4 PDZ and LIM domain 4 1.505
LRRC75B leucine rich repeat containing 75B 1.487
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 1.487
UPB1 ureidopropionase, beta 1.487
GUCD1 guanylyl cyclase domain containing 1 1.487
ADORA2A adenosine A2a receptor 1.487
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 1.487
CRYBA2 crystallin, beta A2 1.478
SYN2 synapsin II 1.451
CFL1 cofilin 1 (non-muscle) 1.449
OVOL1 ovo-like zinc finger 1 1.449
AP5B1 adaptor-related protein complex 5, beta 1 subunit 1.449
C8ORF74 chromosome 8 open reading frame 74 1.447
RP1L1 retinitis pigmentosa 1-like 1 1.447
SOX7 SRY (sex determining region Y)-box 7 1.447
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 1.447
RANBP2 RAN binding protein 2 1.445
EDAR ectodysplasin A receptor 1.445
CCDC138 coiled-coil domain containing 138 1.445
TIMP4 TIMP metallopeptidase inhibitor 4 1.395
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 1.365
PYGM phosphorylase, glycogen, muscle 1.365
GPHA2 glycoprotein hormone alpha 2 1.365
ATG2A autophagy related 2A 1.365
MEN1 multiple endocrine neoplasia I 1.365
SF1 splicing factor 1 1.365
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 1.365
EHD1 EH-domain containing 1 1.365
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 1.365
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 1.365
MYEOV myeloma overexpressed 1.359
CRELD2 cysteine-rich with EGF-like domains 2 1.238
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 1.238
ALG12 ALG12, alpha-1,6-mannosyltransferase 1.238
IL17REL interleukin 17 receptor E-like 1.238
ZBED4 zinc finger, BED-type containing 4 1.238
TTLL8 tubulin tyrosine ligase-like family member 8 1.238
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.22
LRP4 low density lipoprotein receptor-related protein 4 1.22
DDB2 damage-specific DNA binding protein 2, 48kDa 1.22
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 1.22
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 1.22
CCDC57 coiled-coil domain containing 57 1.198
FASN fatty acid synthase 1.198
CSNK1D casein kinase 1, delta 1.198
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 1.198
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 1.198
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 1.19
FST follistatin 1.188
ATG5 autophagy related 5 1.182
PRDM1 PR domain containing 1, with ZNF domain 1.182
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 1.158
DLG1 discs, large homolog 1 (Drosophila) 1.156
MELTF melanotransferrin 1.156
SELE selectin E 1.153
SELL selectin L 1.153
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.153
F5 coagulation factor V (proaccelerin, labile factor) 1.153
PTPRR protein tyrosine phosphatase, receptor type, R 1.143
TSPAN8 tetraspanin 8 1.143
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 1.143
EDNRA endothelin receptor type A 1.059
SULT4A1 sulfotransferase family 4A, member 1 1.034
PNPLA3 patatin-like phospholipase domain containing 3 1.034
PNPLA5 patatin-like phospholipase domain containing 5 1.034
DLC1 DLC1 Rho GTPase activating protein 1.034
SHB Src homology 2 domain containing adaptor protein B 1.034
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.034
NAV2 neuron navigator 2 1.034
PARVB parvin, beta 1.034
SAMM50 SAMM50 sorting and assembly machinery component 1.034
TVP23A trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) 1.023
ZNRF3 zinc and ring finger 3 0.988
KREMEN1 kringle containing transmembrane protein 1 0.988
C22ORF31 chromosome 22 open reading frame 31 0.988
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.961
RAD50 RAD50 homolog (S. cerevisiae) 0.961
INAVA innate immunity activator 0.961
KIF21B kinesin family member 21B 0.961
PARD6G par-6 family cell polarity regulator gamma 0.961
GPR25 G protein-coupled receptor 25 0.961
FCHO2 FCH domain only 2 0.961
ADNP2 ADNP homeobox 2 0.961
IL5 interleukin 5 0.961
TNPO1 transportin 1 0.961
USP8 ubiquitin specific peptidase 8 0.929
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.929
USP50 ubiquitin specific peptidase 50 0.929
ARL2 ADP-ribosylation factor-like 2 0.828
BATF2 basic leucine zipper transcription factor, ATF-like 2 0.828
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 0.633
H2BC13 H2B clustered histone 13 0.621
H2BC14 H2B clustered histone 14 0.621
H2BC17 H2B clustered histone 17 0.621
H2BC15 H2B clustered histone 15 0.621
H4C13 H4 clustered histone 13 0.621
LINC02983 long intergenic non-protein coding RNA 2983 0.621
H4C12 H4 clustered histone 12 0.621
H3C12 H3 clustered histone 12 0.621
H4C11 H4 clustered histone 11 0.621
H2AC16 H2A clustered histone 16 0.621
H3C10 H3 clustered histone 10 0.621
H3C11 H3 clustered histone 11 0.621
H2AC13 H2A clustered histone 13 0.621
H2AC14 H2A clustered histone 14 0.621
APP-DT APP divergent transcript 0.621
H1-5 H1.5 linker histone, cluster member 0.621
SOAT1 sterol O-acyltransferase 1 0.552
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.552
AXDND1 axonemal dynein light chain domain containing 1 0.552
CKAP2L cytoskeleton associated protein 2-like 0.549
IL1B interleukin 1, beta 0.549
IL1A interleukin 1, alpha 0.549
IL37 interleukin 37 0.549
SNX32 sorting nexin 32 0.527
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.514
GLI2 GLI family zinc finger 2 0.512