Acne Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors. (Experimental Factor Ontology, EFO_0003894)
External Link https://www.disgenet.org/browser/0/1/0/C0702166
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Genes

174 genes associated with the disease Acne in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2
ACE angiotensin I converting enzyme
ADHFE1 alcohol dehydrogenase, iron containing, 1
ADIPOQ adiponectin, C1Q and collagen domain containing
AGA aspartylglucosaminidase
AIP aryl hydrocarbon receptor interacting protein
ANGPTL3 angiopoietin-like 3
ANGPTL4 angiopoietin-like 4
ANXA6 annexin A6
APH1A APH1A gamma secretase subunit
APOC3 apolipoprotein C-III
AR androgen receptor
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BDNF brain-derived neurotrophic factor
C11ORF49 chromosome 11 open reading frame 49
C1ORF112 chromosome 1 open reading frame 112
C4A complement component 4A (Rodgers blood group)
CALCA calcitonin-related polypeptide alpha
CAMP cathelicidin antimicrobial peptide
CAV1 caveolin 1, caveolae protein, 22kDa
CCL5 chemokine (C-C motif) ligand 5
CCL7 chemokine (C-C motif) ligand 7
CCR1 chemokine (C-C motif) receptor 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD79A CD79a molecule, immunoglobulin-associated alpha
CD83 CD83 molecule
CDH23 cadherin-related 23
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMT catechol-O-methyltransferase
CRH corticotropin releasing hormone
CXCL8 chemokine (C-X-C motif) ligand 8
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DCD dermcidin
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
DEFB4B defensin, beta 4B
DNAH11 dynein, axonemal, heavy chain 11
DNMT1 DNA (cytosine-5-)-methyltransferase 1
ECM1 extracellular matrix protein 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FGFR2 fibroblast growth factor receptor 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GALNS galactosamine (N-acetyl)-6-sulfatase
GAST gastrin
GLI3 GLI family zinc finger 3
GNLY granulysin
GP1BB glycoprotein Ib (platelet), beta polypeptide
GPR101 G protein-coupled receptor 101
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HDAC8 histone deacetylase 8
HDAC9 histone deacetylase 9
HIRA histone cell cycle regulator
HLA-B major histocompatibility complex, class I, B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IL10 interleukin 10
IL12A interleukin 12A
IL17A interleukin 17A
IL18 interleukin 18
IL18BP interleukin 18 binding protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL23R interleukin 23 receptor
IL6 interleukin 6
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
JMJD1C jumonji domain containing 1C
KLK3 kallikrein-related peptidase 3
KLRC4 killer cell lectin-like receptor subfamily C, member 4
L1CAM L1 cell adhesion molecule
LCN2 lipocalin 2
LEP leptin
LGALS7 lectin, galactoside-binding, soluble, 7
LGALS7B lectin, galactoside-binding, soluble, 7B
LHCGR luteinizing hormone/choriogonadotropin receptor
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LPIN2 lipin 2
LPL lipoprotein lipase
LYZ lysozyme
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK8 mitogen-activated protein kinase 8
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEFV Mediterranean fever
MEIS2 Meis homeobox 2
MIP major intrinsic protein of lens fiber
MMP2 matrix metallopeptidase 2
NAP1L2 nucleosome assembly protein 1-like 2
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NPEPPS aminopeptidase puromycin sensitive
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAEP progestagen-associated endometrial protein
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNXL3 pecanex-like 3 (Drosophila)
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLAG1 pleiomorphic adenoma gene 1
PLXNA2 plexin A2
POR P450 (cytochrome) oxidoreductase
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PROS1 protein S (alpha)
PSAT1 phosphoserine aminotransferase 1
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RETN resistin
RNASE7 ribonuclease, RNase A family, 7
RPS10 ribosomal protein S10
RREB1 ras responsive element binding protein 1
S100A7 S100 calcium binding protein A7
S100A7A S100 calcium binding protein A7A
SEC24C SEC24 family member C
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETBP1 SET binding protein 1
SFPQ splicing factor proline/glutamine-rich
SH3PXD2B SH3 and PX domains 2B
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMIM10L2A small integral membrane protein 10 like 2A
SMIM10L2B small integral membrane protein 10 like 2B
SOD1 superoxide dismutase 1, soluble
SOX9 SRY (sex determining region Y)-box 9
SREBF1 sterol regulatory element binding transcription factor 1
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAT4 signal transducer and activator of transcription 4
SUGCT succinyl-CoA:glutarate-CoA transferase
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBX1 T-box 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough
TTN titin
UBAC2 UBA domain containing 2
UBASH3B ubiquitin associated and SH3 domain containing B
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UFD1 ubiquitin recognition factor in ER associated degradation 1
UROD uroporphyrinogen decarboxylase
USP8 ubiquitin specific peptidase 8
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT10A wingless-type MMTV integration site family, member 10A
WNT4 wingless-type MMTV integration site family, member 4
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XYLT1 xylosyltransferase I