Acromegaly Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb. (Human Disease Ontology, DOID_2449)
Similar Terms
Downloads & Tools

Genes

269 genes co-occuring with the disease Acromegaly in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
IGF1 insulin-like growth factor 1 (somatomedin C) 4.0
SST somatostatin 3.937
GHR growth hormone receptor 3.681
PRL prolactin 3.454
GHRH growth hormone releasing hormone 3.454
GH1 growth hormone 1 3.204
SSTR5 somatostatin receptor 5 3.192
POMC proopiomelanocortin 3.166
AIP aryl hydrocarbon receptor interacting protein 3.146
SSTR2 somatostatin receptor 2 3.118
GH2 growth hormone 2 3.004
TRH thyrotropin-releasing hormone 2.992
INS insulin 2.986
SSTR1 somatostatin receptor 1 2.882
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.866
MEN1 multiple endocrine neoplasia I 2.854
CSH2 chorionic somatomammotropin hormone 2 2.851
GPR101 G protein-coupled receptor 101 2.828
IGFBP3 insulin-like growth factor binding protein 3 2.806
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.772
SSTR3 somatostatin receptor 3 2.611
GHRHR growth hormone releasing hormone receptor 2.604
GNAS GNAS complex locus 2.578
TBX19 T-box 19 2.53
SSTR4 somatostatin receptor 4 2.487
GCG glucagon 2.446
SNED1 sushi, nidogen and EGF-like domains 1 2.424
IGF2 insulin-like growth factor 2 2.412
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.299
IGFBP1 insulin-like growth factor binding protein 1 2.246
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.204
IGF1R insulin-like growth factor 1 receptor 2.193
PTH parathyroid hormone 2.191
GHRL ghrelin/obestatin prepropeptide 2.186
VIP vasoactive intestinal peptide 2.184
DRD2 dopamine receptor D2 2.164
GHSR growth hormone secretagogue receptor 2.156
POU1F1 POU class 1 homeobox 1 2.155
GAST gastrin 2.152
CRH corticotropin releasing hormone 2.151
LEP leptin 2.07
INSR insulin receptor 2.069
USP8 ubiquitin specific peptidase 8 2.06
PRKACB protein kinase, cAMP-dependent, catalytic, beta 2.048
BGLAP bone gamma-carboxyglutamate (gla) protein 2.028
SHBG sex hormone-binding globulin 1.971
CHGA chromogranin A 1.964
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.955
PPY pancreatic polypeptide 1.955
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.951
AVP arginine vasopressin 1.94
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.933
REN renin 1.927
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.923
TSHB thyroid stimulating hormone, beta 1.917
SOCS2 suppressor of cytokine signaling 2 1.893
PRLR prolactin receptor 1.877
GHDC GH3 domain containing 1.875
PROP1 PROP paired-like homeobox 1 1.867
GIP gastric inhibitory polypeptide 1.844
ADIPOQ adiponectin, C1Q and collagen domain containing 1.825
KL klotho 1.813
CORT cortistatin 1.807
STAT5B signal transducer and activator of transcription 5B 1.794
IRS1 insulin receptor substrate 1 1.793
GIPR gastric inhibitory polypeptide receptor 1.789
TP53 tumor protein p53 1.782
SCT secretin 1.764
ESR1 estrogen receptor 1 1.758
ALB albumin 1.739
USP48 ubiquitin specific peptidase 48 1.723
PDE11A phosphodiesterase 11A 1.723
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.717
RET ret proto-oncogene 1.715
FGF23 fibroblast growth factor 23 1.709
SYP synaptophysin 1.702
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.701
GLP1R glucagon-like peptide 1 receptor 1.674
IGFBP5 insulin-like growth factor binding protein 5 1.665
STAT5A signal transducer and activator of transcription 5A 1.648
MLN motilin 1.648
IGFALS insulin-like growth factor binding protein, acid labile subunit 1.648
DPP4 dipeptidyl-peptidase 4 1.646
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 1.623
GAL galanin/GMAP prepropeptide 1.609
ARRB1 arrestin, beta 1 1.604
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1.6
PTTG1 pituitary tumor-transforming 1 1.591
JAK2 Janus kinase 2 1.586
IL6 interleukin 6 1.581
ARRB2 arrestin, beta 2 1.579
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.573
TG thyroglobulin 1.561
CRP C-reactive protein, pentraxin-related 1.56
ACE angiotensin I converting enzyme 1.551
IGF2R insulin-like growth factor 2 receptor 1.55
SLCO2A1 solute carrier organic anion transporter family, member 2A1 1.535
CISH cytokine inducible SH2-containing protein 1.532
AHR aryl hydrocarbon receptor 1.532
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1.526
PPARG peroxisome proliferator-activated receptor gamma 1.524
FSHB follicle stimulating hormone, beta polypeptide 1.515
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.508
NTS neurotensin 1.504
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.502
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.502
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.498
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.496
HNF1A HNF1 homeobox A 1.489
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.486
CDC73 cell division cycle 73 1.483
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.477
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.477
EGF epidermal growth factor 1.468
TNF tumor necrosis factor 1.442
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.44
PDE8B phosphodiesterase 8B 1.429
IRS2 insulin receptor substrate 2 1.422
OXT oxytocin/neurophysin I prepropeptide 1.417
SOST sclerostin 1.404
CCK cholecystokinin 1.403
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.403
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.396
NPY neuropeptide Y 1.396
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.392
RETN resistin 1.391
NF1 neurofibromin 1 1.387
TSHR thyroid stimulating hormone receptor 1.374
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.369
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.368
TRHR thyrotropin-releasing hormone receptor 1.367
AVPR1B arginine vasopressin receptor 1B 1.365
RETNLB resistin like beta 1.362
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.361
TGFB1 transforming growth factor, beta 1 1.361
PTHLH parathyroid hormone-like hormone 1.344
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.341
SHOX short stature homeobox 1.339
PAPPA2 pappalysin 2 1.335
FGF21 fibroblast growth factor 21 1.333
CASR calcium-sensing receptor 1.324
AGRP agouti related neuropeptide 1.324
LPL lipoprotein lipase 1.313
IGFBP4 insulin-like growth factor binding protein 4 1.31
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.309
CREB1 cAMP responsive element binding protein 1 1.304
NAMPT nicotinamide phosphoribosyltransferase 1.304
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.304
MSTN myostatin 1.302
PLAGL1 pleiomorphic adenoma gene-like 1 1.3
EGFR epidermal growth factor receptor 1.292
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.292
NPPA natriuretic peptide A 1.292
PTEN phosphatase and tensin homolog 1.29
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.29
SDHAF2 succinate dehydrogenase complex assembly factor 2 1.289
TAC1 tachykinin, precursor 1 1.289
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.289
FLNA filamin A, alpha 1.286
CIDEC cell death-inducing DFFA-like effector c 1.286
FGF4 fibroblast growth factor 4 1.28
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.279
FGF8 fibroblast growth factor 8 (androgen-induced) 1.273
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.27
APOA1 apolipoprotein A-I 1.27
FGF2 fibroblast growth factor 2 (basic) 1.269
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.269
PXDNL peroxidasin-like 1.269
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.268
KISS1 KiSS-1 metastasis-suppressor 1.268
MGMT O-6-methylguanine-DNA methyltransferase 1.268
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.267
PXDN peroxidasin 1.267
IL1B interleukin 1, beta 1.266
TPO thyroid peroxidase 1.266
FGF10 fibroblast growth factor 10 1.261
PAPPA pregnancy-associated plasma protein A, pappalysin 1 1.259
IGFBP6 insulin-like growth factor binding protein 6 1.259
ESRP1 epithelial splicing regulatory protein 1 1.258
FGF18 fibroblast growth factor 18 1.249
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 1.242
CDKN2A cyclin-dependent kinase inhibitor 2A 1.24
NPPB natriuretic peptide B 1.235
FGF22 fibroblast growth factor 22 1.235
FGF16 fibroblast growth factor 16 1.234
TMEM127 transmembrane protein 127 1.234
FGF17 fibroblast growth factor 17 1.229
FGF3 fibroblast growth factor 3 1.228
FGF6 fibroblast growth factor 6 1.225
FGF20 fibroblast growth factor 20 1.223
FGF7 fibroblast growth factor 7 1.221
CABLES1 Cdk5 and Abl enzyme substrate 1 1.22
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.218
FGF5 fibroblast growth factor 5 1.217
FGF9 fibroblast growth factor 9 1.216
MAX MYC associated factor X 1.213
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.21
LIPC lipase, hepatic 1.21
MAPK3 mitogen-activated protein kinase 3 1.209
FGFR4 fibroblast growth factor receptor 4 1.209
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.209
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.206
SCGB1D4 secretoglobin, family 1D, member 4 1.2
IGSF1 immunoglobulin superfamily, member 1 1.195
CCND1 cyclin D1 1.191
LIPE lipase, hormone-sensitive 1.187
EPO erythropoietin 1.182
ENO2 enolase 2 (gamma, neuronal) 1.18
ZFAND3 zinc finger, AN1-type domain 3 1.179
LEPR leptin receptor 1.177
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.167
RUNX2 runt-related transcription factor 2 1.167
APOB apolipoprotein B 1.158
HMGA2 high mobility group AT-hook 2 1.157
ACTB actin, beta 1.156
GRP gastrin-releasing peptide 1.155
AMH anti-Mullerian hormone 1.154
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 1.146
FOS FBJ murine osteosarcoma viral oncogene homolog 1.14
LHX3 LIM homeobox 3 1.139
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.138
DRD5 dopamine receptor D5 1.134
GATA2 GATA binding protein 2 1.123
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.12
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.116
FNDC5 fibronectin type III domain containing 5 1.114
CGA glycoprotein hormones, alpha polypeptide 1.106
SOCS1 suppressor of cytokine signaling 1 1.105
HESX1 HESX homeobox 1 1.104
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.101
CDKN3 cyclin-dependent kinase inhibitor 3 1.1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.089
GC group-specific component (vitamin D binding protein) 1.081
AKNAD1 AKNA domain containing 1 1.079
DENND11 DENN domain containing 11 1.075
GFRA4 GDNF family receptor alpha 4 1.072
EDN1 endothelin 1 1.062
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.06
NKX2-1 NK2 homeobox 1 1.058
GDNF glial cell derived neurotrophic factor 1.056
DRD1 dopamine receptor D1 1.056
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.055
GCK glucokinase (hexokinase 4) 1.05
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.048
KLK3 kallikrein-related peptidase 3 1.046
PEBP1 phosphatidylethanolamine binding protein 1 1.044
MYH14 myosin, heavy chain 14, non-muscle 1.041
TSC2 tuberous sclerosis 2 1.038
CKB creatine kinase, brain 1.037
JUN jun proto-oncogene 1.036
GATA3 GATA binding protein 3 1.036
CKM creatine kinase, muscle 1.035
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.034
L3HYPDH L-3-hydroxyproline dehydratase (trans-) 1.031
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.031
CKMT1B creatine kinase, mitochondrial 1B 1.03
GNRHR gonadotropin-releasing hormone receptor 1.026
MMP9 matrix metallopeptidase 9 1.025
TTR transthyretin 1.016
NEUROD1 neuronal differentiation 1 1.014
ESR2 estrogen receptor 2 (ER beta) 1.014
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.012
CETP cholesteryl ester transfer protein, plasma 1.011
PDE2A phosphodiesterase 2A, cGMP-stimulated 1.009
WWC3 WWC family member 3 1.006
BMP4 bone morphogenetic protein 4 1.003
GFRA1 GDNF family receptor alpha 1 1.003
UTS2 urotensin 2 1.003
CRHR1 corticotropin releasing hormone receptor 1 1.001