Acromegaly Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb. (Human Disease Ontology, DOID_2449)
External Link https://www.disgenet.org/browser/0/1/0/C0001206
Similar Terms
Downloads & Tools

Genes

132 genes associated with the disease Acromegaly in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACE angiotensin I converting enzyme
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AIP aryl hydrocarbon receptor interacting protein
ALPP alkaline phosphatase, placental
AMH anti-Mullerian hormone
APOE apolipoprotein E
ARHGAP24 Rho GTPase activating protein 24
ARRB1 arrestin, beta 1
ASRGL1 asparaginase like 1
ATRNL1 attractin-like 1
BAX BCL2-associated X protein
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD2 bromodomain containing 2
CA1 carbonic anhydrase I
CALCA calcitonin-related polypeptide alpha
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CCL27 chemokine (C-C motif) ligand 27
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK2 checkpoint kinase 2
CIB1 calcium and integrin binding 1 (calmyrin)
CISH cytokine inducible SH2-containing protein
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTSB cathepsin B
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
DGCR2 DiGeorge syndrome critical region gene 2
DMBT1 deleted in malignant brain tumors 1
DPP4 dipeptidyl-peptidase 4
E2F1 E2F transcription factor 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF6 eukaryotic translation initiation factor 6
ESRP1 epithelial splicing regulatory protein 1
FGF2 fibroblast growth factor 2 (basic)
FGF21 fibroblast growth factor 21
FLNA filamin A, alpha
FTO fat mass and obesity associated
GCG glucagon
GDNF glial cell derived neurotrophic factor
GH1 growth hormone 1
GHR growth hormone receptor
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GHRL ghrelin/obestatin prepropeptide
GIP gastric inhibitory polypeptide
GIPR gastric inhibitory polypeptide receptor
GLP1R glucagon-like peptide 1 receptor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAS GNAS complex locus
GPR101 G protein-coupled receptor 101
GPRC5C G protein-coupled receptor, class C, group 5, member C
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRK2 G protein-coupled receptor kinase 2
GSTP1 glutathione S-transferase pi 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGSF1 immunoglobulin superfamily, member 1
INS insulin
JAK2 Janus kinase 2
KL klotho
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LPL lipoprotein lipase
MEN1 multiple endocrine neoplasia I
MIB1 mindbomb E3 ubiquitin protein ligase 1
MKI67 marker of proliferation Ki-67
MMP2 matrix metallopeptidase 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NAT10 N-acetyltransferase 10 (GCN5-related)
NCAM1 neural cell adhesion molecule 1
NDRG2 NDRG family member 2
NPDC1 neural proliferation, differentiation and control, 1
NPPB natriuretic peptide B
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OGG1 8-oxoguanine DNA glycosylase
PDLIM3 PDZ and LIM domain 3
PLAGL1 pleiomorphic adenoma gene-like 1
POMC proopiomelanocortin
POU1F1 POU class 1 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRL prolactin
PTH parathyroid hormone
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRF protein tyrosine phosphatase, receptor type, F
RAB18 RAB18, member RAS oncogene family
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
REN renin
RENBP renin binding protein
RET ret proto-oncogene
RORC RAR-related orphan receptor C
S100A1 S100 calcium binding protein A1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SMS spermine synthase
SOCS2 suppressor of cytokine signaling 2
SOST sclerostin
SRL sarcalumenin
SST somatostatin
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2
SSTR5 somatostatin receptor 5
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TP73 tumor protein p73
TRH thyrotropin-releasing hormone
TRHR thyrotropin-releasing hormone receptor
TRIM21 tripartite motif containing 21
TWIST1 twist family bHLH transcription factor 1
TXN thioredoxin
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UTS2 urotensin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
ZACN zinc activated ligand-gated ion channel
ZGLP1 zinc finger, GATA-like protein 1
ZHX2 zinc fingers and homeoboxes 2