Acute Chest Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph. (Human Disease Ontology, DOID_1584)
External Link https://www.disgenet.org/browser/0/1/0/C0742343
Similar Terms
Downloads & Tools

Genes

360 genes associated with the disease Acute Chest Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ACSL6 acyl-CoA synthetase long-chain family member 6
ACSS2 acyl-CoA synthetase short-chain family member 2
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPT2 angiopoietin 2
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
APLN apelin
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
ARG1 arginase 1
ARSA arylsulfatase A
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
AVP arginine vasopressin
AZU1 azurocidin 1
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BEST1 bestrophin 1
BMP4 bone morphogenetic protein 4
BMS1 BMS1 ribosome biogenesis factor
BSG basigin (Ok blood group)
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CARM1 coactivator-associated arginine methyltransferase 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCHCR1 coiled-coil alpha-helical rod protein 1
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCN1 cellular communication network factor 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCS copper chaperone for superoxide dismutase
CD14 CD14 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD80 CD80 molecule
CETP cholesteryl ester transfer protein, plasma
CHDH choline dehydrogenase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIITA class II, major histocompatibility complex, transactivator
CKM creatine kinase, muscle
COL3A1 collagen, type III, alpha 1
COX1
COX2
CPB2 carboxypeptidase B2 (plasma)
CRISP2 cysteine-rich secretory protein 2
CRP C-reactive protein, pentraxin-related
CRYGC crystallin, gamma C
CSF3 colony stimulating factor 3 (granulocyte)
CSHL1 chorionic somatomammotropin hormone-like 1
CST3 cystatin C
CUBN cubilin (intrinsic factor-cobalamin receptor)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DGCR8 DGCR8 microprocessor complex subunit
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DLX5 distal-less homeobox 5
DLX6 distal-less homeobox 6
DNER delta/notch-like EGF repeat containing
EDN1 endothelin 1
EDNRA endothelin receptor type A
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELOVL2 ELOVL fatty acid elongase 2
ENHO energy homeostasis associated
EPHX2 epoxide hydrolase 2, cytoplasmic
EPO erythropoietin
F10 coagulation factor X
F3 coagulation factor III (thromboplastin, tissue factor)
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAS Fas cell surface death receptor
FASN fatty acid synthase
FBN1 fibrillin 1
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FEV FEV (ETS oncogene family)
FGB fibrinogen beta chain
FGF23 fibroblast growth factor 23
FOXD3 forkhead box D3
FOXP3 forkhead box P3
FSD1 fibronectin type III and SPRY domain containing 1
FSD1L fibronectin type III and SPRY domain containing 1-like
FSTL1 follistatin-like 1
FTO fat mass and obesity associated
G6PD glucose-6-phosphate dehydrogenase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4
GAS6 growth arrest-specific 6
GCG glucagon
GCK glucokinase (hexokinase 4)
GDE1 glycerophosphodiester phosphodiesterase 1
GDF15 growth differentiation factor 15
GIF gastric intrinsic factor (vitamin B synthesis)
GJA4 gap junction protein, alpha 4, 37kDa
GLI3 GLI family zinc finger 3
GLP1R glucagon-like peptide 1 receptor
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GREM1 gremlin 1, DAN family BMP antagonist
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HAMP hepcidin antimicrobial peptide
HBA1 hemoglobin, alpha 1
HBA2 hemoglobin, alpha 2
HDAC9 histone deacetylase 9
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HPX hemopexin
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HYAL2 hyaluronoglucosaminidase 2
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGFBP4 insulin-like growth factor binding protein 4
IL10 interleukin 10
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL17D interleukin 17D
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL27 interleukin 27
IL2RA interleukin 2 receptor, alpha
IL33 interleukin 33
IL37 interleukin 37
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
INSRR insulin receptor-related receptor
IRAK3 interleukin-1 receptor-associated kinase 3
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
IRS1 insulin receptor substrate 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
JAK2 Janus kinase 2
JPH3 junctophilin 3
JUP junction plakoglobin
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5
KDR kinase insert domain receptor
KLF2 Kruppel-like factor 2
KLK1 kallikrein 1
KRT20 keratin 20, type I
L1CAM L1 cell adhesion molecule
LASP1 LIM and SH3 protein 1
LCAT lecithin-cholesterol acyltransferase
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPG lipase, endothelial
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LRP2 low density lipoprotein receptor-related protein 2
LRRC32 leucine rich repeat containing 32
MAPK8 mitogen-activated protein kinase 8
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MARCH9 membrane-associated ring finger (C3HC4) 9
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MGP matrix Gla protein
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MMRN1 multimerin 1
MOK MOK protein kinase
MPO myeloperoxidase
MRAS muscle RAS oncogene homolog
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSR1 macrophage scavenger receptor 1
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MVD mevalonate (diphospho) decarboxylase
MYDGF myeloid-derived growth factor
NANOS1 nanos homolog 1 (Drosophila)
NANOS3 nanos homolog 3 (Drosophila)
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NF2 neurofibromin 2 (merlin)
NFE2L2 nuclear factor, erythroid 2-like 2
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NPR3 natriuretic peptide receptor 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRDC nardilysin convertase
OGG1 8-oxoguanine DNA glycosylase
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
OR10A4 olfactory receptor, family 10, subfamily A, member 4
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PADI4 peptidyl arginine deiminase, type IV
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PEAR1 platelet endothelial aggregation receptor 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PLA2G15 phospholipase A2, group XV
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PLB1 phospholipase B1
PLCB4 phospholipase C, beta 4
PLXNA2 plexin A2
POLR1H RNA polymerase I subunit H
POMC proopiomelanocortin
PON1 paraoxonase 1
POR P450 (cytochrome) oxidoreductase
POU2F3 POU class 2 homeobox 3
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRSS55 protease, serine, 55
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTX3 pentraxin 3, long
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM45 RNA binding motif protein 45
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RNF39 ring finger protein 39
RNH1 ribonuclease/angiogenin inhibitor 1
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SELE selectin E
SELENBP1 selenium binding protein 1
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHBG sex hormone-binding globulin
SIRT1 sirtuin 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD3 SMAD family member 3
SMPX small muscle protein, X-linked
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOCS1 suppressor of cytokine signaling 1
SPP1 secreted phosphoprotein 1
SPZ1 spermatogenic leucine zipper 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBX21 T-box 21
TCF21 transcription factor 21
TERF2IP telomeric repeat binding factor 2, interacting protein
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
THBD thrombomodulin
THBS1 thrombospondin 1
THPO thrombopoietin
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TP53 tumor protein p53
TTR transthyretin
TYR tyrosinase
UBAP1 ubiquitin associated protein 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VASP vasodilator-stimulated phosphoprotein
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
VSIR V-set immunoregulatory receptor
VWF von Willebrand factor
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZC3H12A zinc finger CCCH-type containing 12A
ZGLP1 zinc finger, GATA-like protein 1