Acute Kidney Injury Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia). (Human Phenotype Ontology, HP_0001919)
External Link https://www.disgenet.org/browser/0/1/0/C2609414
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Genes

168 genes associated with the disease Acute Kidney Injury in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ACE angiotensin I converting enzyme
ADRB2 adrenoceptor beta 2, surface
AFM afamin
AHSG alpha-2-HS-glycoprotein
ALAD aminolevulinate dehydratase
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
AMBP alpha-1-microglobulin/bikunin precursor
AMN amnion associated transmembrane protein
ANXA1 annexin A1
AR androgen receptor
ARG1 arginase 1
ARG2 arginase 2
ATP5F1B ATP synthase F1 subunit beta
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
B2M beta-2-microglobulin
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BDKRB2 bradykinin receptor B2
C3 complement component 3
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CAPN1 calpain 1, (mu/I) large subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CFH complement factor H
CFHR1 complement factor H-related 1
CFHR3 complement factor H-related 3
CFI complement factor I
CLU clusterin
CORIN corin, serine peptidase
CP ceruloplasmin (ferroxidase)
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DGKE diacylglycerol kinase, epsilon 64kDa
ECE1 endothelin converting enzyme 1
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EPAS1 endothelial PAS domain protein 1
EPHX2 epoxide hydrolase 2, cytoplasmic
EPO erythropoietin
FGA fibrinogen alpha chain
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FSTL1 follistatin-like 1
G6PD glucose-6-phosphate dehydrogenase
GAS6 growth arrest-specific 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GC group-specific component (vitamin D binding protein)
GFER growth factor, augmenter of liver regeneration
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GPNMB glycoprotein (transmembrane) nmb
GSK3B glycogen synthase kinase 3 beta
GSR glutathione reductase
GSTA1 glutathione S-transferase alpha 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTP1 glutathione S-transferase pi 1
HAVCR1 hepatitis A virus cellular receptor 1
HBEGF heparin-binding EGF-like growth factor
HBG2 hemoglobin, gamma G
HDAC3 histone deacetylase 3
HDAC5 histone deacetylase 5
HES1 hes family bHLH transcription factor 1
HEXB hexosaminidase B (beta polypeptide)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMOX1 heme oxygenase 1
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HP haptoglobin
HPRT1 hypoxanthine phosphoribosyltransferase 1
HPX hemopexin
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ICAM1 intercellular adhesion molecule 1
IFNA2 interferon, alpha 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IL10 interleukin 10
IL1B interleukin 1, beta
IL20 interleukin 20
IL6 interleukin 6
INS insulin
KLK1 kallikrein 1
KNG1 kininogen 1
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LPIN1 lipin 1
LRP2 low density lipoprotein receptor-related protein 2
MB myoglobin
MET MET proto-oncogene, receptor tyrosine kinase
MFN1 mitofusin 1
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NES nestin
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NQO1 NAD(P)H dehydrogenase, quinone 1
OCLN occludin
ORM1 orosomucoid 1
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLG plasminogen
POMC proopiomelanocortin
PPARG peroxisome proliferator-activated receptor gamma
PROCR protein C receptor, endothelial
PTAFR platelet-activating factor receptor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RB1 retinoblastoma 1
RYR1 ryanodine receptor 1 (skeletal)
SAA1 serum amyloid A1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIRT1 sirtuin 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A24 solute carrier family 22, member 24
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SOD1 superoxide dismutase 1, soluble
SPP1 secreted phosphoprotein 1
STOX1 storkhead box 1
TCN2 transcobalamin II
TF transferrin
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP53 tumor protein p53
TRIM25 tripartite motif containing 25
TTR transthyretin
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UTS2R urotensin 2 receptor
VEGFA vascular endothelial growth factor A
WNT4 wingless-type MMTV integration site family, member 4
XDH xanthine dehydrogenase