Acute Lung Injury Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Acute lung injury (ALI) is a diffuse heterogeneous lung injury characterized by hypoxemia, non cardiogenic pulmonary edema, low lung compliance and widespread capillary leakage. ALI is caused by any stimulus of local or systemic inflammation, principally sepsis. (Experimental Factor Ontology, EFO_0004610)
External Link https://www.disgenet.org/browser/0/1/0/C0242488
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Genes

91 genes associated with the disease Acute Lung Injury in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACVR1 activin A receptor, type I
ADAR adenosine deaminase, RNA-specific
ADRA2A adrenoceptor alpha 2A
AGER advanced glycosylation end product-specific receptor
AKAP12 A kinase (PRKA) anchor protein 12
ALB albumin
APOA1 apolipoprotein A-I
AQP5 aquaporin 5
ASCL1 achaete-scute family bHLH transcription factor 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
C3 complement component 3
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL6 chemokine (C-X-C motif) ligand 6
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
EDN1 endothelin 1
ELANE elastase, neutrophil expressed
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGA fibrinogen alpha chain
FLT1 fms-related tyrosine kinase 1
GJA1 gap junction protein, alpha 1, 43kDa
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GSR glutathione reductase
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL10 interleukin 10
IL13 interleukin 13
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL33R interleukin 33 receptor
IL4 interleukin 4
IL6 interleukin 6
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KDR kinase insert domain receptor
MFN1 mitofusin 1
MFN2 mitofusin 2
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
MYLK myosin light chain kinase
NFE2L2 nuclear factor, erythroid 2-like 2
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NQO1 NAD(P)H dehydrogenase, quinone 1
OPA1 optic atrophy 1 (autosomal dominant)
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAWR PRKC, apoptosis, WT1, regulator
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PPARG peroxisome proliferator-activated receptor gamma
PROCR protein C receptor, endothelial
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPD surfactant protein D
SLPI secretory leukocyte peptidase inhibitor
TFF1 trefoil factor 1
TFF2 trefoil factor 2
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TIMP2 TIMP metallopeptidase inhibitor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TXN thioredoxin
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
XDH xanthine dehydrogenase