Acute Lymphoblastic Leukemia Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description When the disease process is confined to a mass lesion with no or minimal evidence of blood and less than 25% marrow involvement, the diagnosis is lymphoblastic lymphoma; with blood and greater than 25% marrow involvement, ALL is the appropriate term.|Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.|A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.|A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.|Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the precursor B lymphoblastic leukemia and precursor T lymphoblastic leukemia. (Experimental Factor Ontology, EFO_0000220)
External Link https://www.disgenet.org/browser/0/1/0/C0522628
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Genes

26 genes associated with the disease Acute Lymphoblastic Leukemia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ARR3 arrestin 3, retinal (X-arrestin)
CASR calcium-sensing receptor
CRLF2 cytokine receptor-like factor 2
CXADR coxsackie virus and adenovirus receptor
DES desmin
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGFR1 fibroblast growth factor receptor 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
JAK1 Janus kinase 1
JAK2 Janus kinase 2
MTAP methylthioadenosine phosphorylase
NR1I3 nuclear receptor subfamily 1, group I, member 3
PAX5 paired box 5
PBX1 pre-B-cell leukemia homeobox 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
S100A1 S100 calcium binding protein A1
S100B S100 calcium binding protein B
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
TPO thyroid peroxidase
TRIM13 tripartite motif containing 13