| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.205526 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.183424 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.106989 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0803926 |
| AHNAK | AHNAK nucleoprotein | 0.077948 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0768281 |
| PLAT | plasminogen activator, tissue | 0.0761677 |
| CALR | calreticulin | 0.0734364 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0681167 |
| TMSB4X | thymosin beta 4, X-linked | 0.0668004 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0640784 |
| UBC | ubiquitin C | 0.062928 |
| COL3A1 | collagen, type III, alpha 1 | 0.0609002 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0582797 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0576157 |
| AUTS2 | autism susceptibility candidate 2 | 0.0575088 |
| FBN1 | fibrillin 1 | 0.0565067 |
| APP | amyloid beta (A4) precursor protein | 0.0557063 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0521404 |
| COL5A2 | collagen, type V, alpha 2 | 0.0507275 |
| PTMA | prothymosin, alpha | 0.0495688 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0455592 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0451576 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0450965 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0450312 |
| DST | dystonin | 0.0438059 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0429348 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0424707 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0415118 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.0414774 |
| ATP13A3 | ATPase type 13A3 | 0.041432 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0390503 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0387165 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0383194 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0373398 |
| VEGFA | vascular endothelial growth factor A | 0.036454 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0359881 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0359613 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.035675 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0353888 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0337423 |
| GPC6 | glypican 6 | 0.0333714 |
| MCL1 | myeloid cell leukemia 1 | 0.0332987 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0332602 |
| FRMD4A | FERM domain containing 4A | 0.0323488 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0321499 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0308924 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0308786 |
| TPM3 | tropomyosin 3 | 0.0307374 |
| NCKAP1 | NCK-associated protein 1 | 0.0290988 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0289959 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0287328 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0287308 |
| NAV2 | neuron navigator 2 | 0.028341 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0280842 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.028051 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0280021 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0277463 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.027102 |
| SET | SET nuclear proto-oncogene | 0.0268266 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0261527 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0260948 |
| SFTPA2 | surfactant protein A2 | 0.0260541 |
| FRMD5 | FERM domain containing 5 | 0.0258083 |
| SEPTIN9 | septin 9 | 0.0253078 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0252381 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0250844 |
| CDH13 | cadherin 13 | 0.0243315 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0243038 |
| OGA | O-GlcNAcase | 0.0242829 |
| HDAC9 | histone deacetylase 9 | 0.0240307 |
| AFDN | afadin, adherens junction formation factor | 0.0240031 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0237666 |
| FMNL2 | formin-like 2 | 0.0237287 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0236909 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0231521 |
| HDGF | hepatoma-derived growth factor | 0.0229346 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0225712 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0225226 |
| MSN | moesin | 0.0223604 |
| DENND5A | DENN/MADD domain containing 5A | 0.0223505 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0223434 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0220886 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0219337 |
| STEAP3 | STEAP family member 3, metalloreductase | 0.0218358 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0218085 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0216663 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0216516 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0215197 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0204146 |
| CLIC1 | chloride intracellular channel 1 | 0.0202849 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0202522 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0202228 |
| FNIP1 | folliculin interacting protein 1 | 0.0201812 |
| PGK1 | phosphoglycerate kinase 1 | 0.0200109 |
| TMF1 | TATA element modulatory factor 1 | 0.0199712 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0199599 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0198022 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0194781 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0194492 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.265492 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.245371 |
| NDRG1 | N-myc downstream regulated 1 | -0.18017 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0967492 |
| PODXL | podocalyxin-like | -0.0964192 |
| LOX | lysyl oxidase | -0.0953855 |
| MT2A | metallothionein 2A | -0.0899942 |
| CD44 | CD44 molecule (Indian blood group) | -0.0803744 |
| TMSB10 | thymosin beta 10 | -0.0768975 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0729523 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0628007 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0605712 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0588207 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0585142 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0576617 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0506019 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0484114 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0482915 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.047448 |
| COL5A1 | collagen, type V, alpha 1 | -0.0471858 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0454857 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0431553 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0411177 |
| RPL35A | ribosomal protein L35a | -0.0410966 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0410628 |
| ANXA2 | annexin A2 | -0.0410549 |
| BSG | basigin (Ok blood group) | -0.0404965 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.040459 |
| RTN4 | reticulon 4 | -0.0402461 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0399406 |
| RUNX1 | runt-related transcription factor 1 | -0.03882 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0386761 |
| MYOF | myoferlin | -0.0379861 |
| FN1 | fibronectin 1 | -0.0375451 |
| MAP1B | microtubule-associated protein 1B | -0.0374313 |
| DCLK2 | doublecortin-like kinase 2 | -0.0361252 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.035476 |
| EGFR | epidermal growth factor receptor | -0.0350666 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0345958 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0335916 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0328627 |
| MEIS2 | Meis homeobox 2 | -0.0326427 |
| GNAS | GNAS complex locus | -0.0321985 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0321037 |
| RAB7A | RAB7A, member RAS oncogene family | -0.031817 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0316945 |
| FOSL1 | FOS-like antigen 1 | -0.0311957 |
| RIGI | RNA sensor RIG-I | -0.0309011 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0305902 |
| THBS2 | thrombospondin 2 | -0.0296336 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0295692 |
| TAPBP | TAP binding protein (tapasin) | -0.0295673 |
| MYADM | myeloid-associated differentiation marker | -0.0294168 |
| PXDN | peroxidasin | -0.0293053 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0292215 |
| FLNB | filamin B, beta | -0.0289918 |
| HLA-C | major histocompatibility complex, class I, C | -0.02896 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0286885 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0285018 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0284842 |
| PKM | pyruvate kinase, muscle | -0.0283944 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0281778 |
| RNF213 | ring finger protein 213 | -0.0279132 |
| ARF1 | ADP-ribosylation factor 1 | -0.0276827 |
| TAGLN2 | transgelin 2 | -0.0274451 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0274126 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0273914 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0272403 |
| ACTN4 | actinin, alpha 4 | -0.027099 |
| RPLP1 | ribosomal protein, large, P1 | -0.0267759 |
| ZNF207 | zinc finger protein 207 | -0.0265429 |
| S100A10 | S100 calcium binding protein A10 | -0.0265341 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.026346 |
| HLA-B | major histocompatibility complex, class I, B | -0.0257834 |
| RPL28 | ribosomal protein L28 | -0.0255222 |
| ITM2B | integral membrane protein 2B | -0.0250171 |
| SMIM44 | small integral membrane protein 44 | -0.0238375 |
| MB21D2 | Mab-21 domain containing 2 | -0.0236446 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0235652 |
| EGR1 | early growth response 1 | -0.0234402 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0232276 |
| MX2 | MX dynamin-like GTPase 2 | -0.0230497 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0228584 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0225828 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0223333 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0222205 |
| MNT | MAX network transcriptional repressor | -0.0221973 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0218408 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0218261 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0218056 |
| MEF2D | myocyte enhancer factor 2D | -0.0214551 |
| GLIS3 | GLIS family zinc finger 3 | -0.0214077 |
| IKBIP | IKBKB interacting protein | -0.0213906 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0213368 |
| GLG1 | golgi glycoprotein 1 | -0.0213238 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.02117 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0211315 |
| DEPP1 | DEPP autophagy regulator 1 | -0.0209947 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0205951 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0205853 |
