| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.229092 |
| ANXA1 | annexin A1 | 0.11647 |
| MKI67 | marker of proliferation Ki-67 | 0.0980886 |
| RRM2 | ribonucleotide reductase M2 | 0.0912533 |
| AREG | amphiregulin | 0.0898042 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0892646 |
| DST | dystonin | 0.0871642 |
| PTMA | prothymosin, alpha | 0.0833514 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0727176 |
| TPI1 | triosephosphate isomerase 1 | 0.0715917 |
| RPS12 | ribosomal protein S12 | 0.0693202 |
| HDGF | hepatoma-derived growth factor | 0.0663476 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0640606 |
| RPS3 | ribosomal protein S3 | 0.0637371 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0623238 |
| LDHA | lactate dehydrogenase A | 0.0572614 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0567683 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.056364 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0556464 |
| RPL3 | ribosomal protein L3 | 0.0493008 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0452909 |
| PGK1 | phosphoglycerate kinase 1 | 0.0452484 |
| SET | SET nuclear proto-oncogene | 0.0438634 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.043639 |
| RPL37 | ribosomal protein L37 | 0.043163 |
| TPM3 | tropomyosin 3 | 0.0422593 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0421848 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0393375 |
| RPL4 | ribosomal protein L4 | 0.0393357 |
| PDGFC | platelet derived growth factor C | 0.0389977 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0388455 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0378886 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0372156 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0371473 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0370204 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0368887 |
| RPL26 | ribosomal protein L26 | 0.0368731 |
| GPX4 | glutathione peroxidase 4 | 0.0366048 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.036594 |
| RPL13A | ribosomal protein L13a | 0.036421 |
| AHNAK | AHNAK nucleoprotein | 0.0358799 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0353344 |
| MTAP | methylthioadenosine phosphorylase | 0.0353265 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.03464 |
| YBX3 | Y box binding protein 3 | 0.0343216 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0342277 |
| CENPF | centromere protein F, 350/400kDa | 0.0335242 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0334639 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0330178 |
| KIF5B | kinesin family member 5B | 0.0324184 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0321523 |
| PNN | pinin, desmosome associated protein | 0.0321443 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0319596 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0318827 |
| CALR | calreticulin | 0.0317188 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0304969 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0299886 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0299796 |
| CEP70 | centrosomal protein 70kDa | 0.0298211 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0297594 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0296693 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0296689 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0291701 |
| CLDN1 | claudin 1 | 0.028996 |
| RPS17 | ribosomal protein S17 | 0.0287564 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0281251 |
| DSPP | dentin sialophosphoprotein | 0.0280412 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0276553 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0272215 |
| HSPE1 | heat shock 10kDa protein 1 | 0.0271653 |
| TPX2 | TPX2, microtubule-associated | 0.027143 |
| RPL27 | ribosomal protein L27 | 0.0271051 |
| PRDX1 | peroxiredoxin 1 | 0.0270965 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0270593 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0270212 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.0268837 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0266872 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0265487 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.026531 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0261515 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0260607 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0259098 |
| LMO7 | LIM domain 7 | 0.0249541 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0247113 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0245013 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0244364 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0236172 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0233976 |
| MSH6 | mutS homolog 6 | 0.0227202 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0225075 |
| STMN1 | stathmin 1 | 0.0224895 |
| NCKAP1 | NCK-associated protein 1 | 0.0223228 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0220784 |
| KRT18 | keratin 18, type I | 0.022064 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0219623 |
| TPR | translocated promoter region, nuclear basket protein | 0.021631 |
| RPL37A | ribosomal protein L37a | 0.0216051 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0215773 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0215151 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0214771 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.242361 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.168242 |
| TMSB10 | thymosin beta 10 | -0.162978 |
| RPL35A | ribosomal protein L35a | -0.107006 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.105246 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0970957 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0879655 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0786032 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0734408 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0683431 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0642541 |
| EGR1 | early growth response 1 | -0.0569629 |
| PCBP2 | poly(rC) binding protein 2 | -0.0566404 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0559654 |
| GNAS | GNAS complex locus | -0.0509199 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0492178 |
| POTEF | POTE ankyrin domain family, member F | -0.0482488 |
| MMP12 | matrix metallopeptidase 12 | -0.0476809 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0473634 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0458264 |
| TXNRD1 | thioredoxin reductase 1 | -0.0455204 |
| ZNF207 | zinc finger protein 207 | -0.0433257 |
| JMJD1C | jumonji domain containing 1C | -0.0432377 |
| RPLP0 | ribosomal protein, large, P0 | -0.0430493 |
| RHOA | ras homolog family member A | -0.040486 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0387721 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0376349 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0375006 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0371014 |
| KLHL24 | kelch-like family member 24 | -0.0357313 |
| RPLP1 | ribosomal protein, large, P1 | -0.0357143 |
| RPS6 | ribosomal protein S6 | -0.0353466 |
| MGAT4C | MGAT4 family, member C | -0.0352575 |
| CCND1 | cyclin D1 | -0.0335869 |
| CPOX | coproporphyrinogen oxidase | -0.0335112 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0322302 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.031727 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0313726 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0312637 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0311208 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0309168 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0308032 |
| RPS19 | ribosomal protein S19 | -0.0300642 |
| TBK1 | TANK-binding kinase 1 | -0.03004 |
| EXOC6B | exocyst complex component 6B | -0.0299534 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.029779 |
| ZNF638 | zinc finger protein 638 | -0.0296493 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0295498 |
| ATP11A | ATPase, class VI, type 11A | -0.0291166 |
| RTN3 | reticulon 3 | -0.0288532 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0285416 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0284954 |
| FBXO11 | F-box protein 11 | -0.028162 |
| RPS20 | ribosomal protein S20 | -0.0279515 |
| S100A6 | S100 calcium binding protein A6 | -0.027727 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0273385 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0271209 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0269719 |
| GSK3B | glycogen synthase kinase 3 beta | -0.026629 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0265373 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0262823 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0261648 |
| HMGA2 | high mobility group AT-hook 2 | -0.0257946 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0256656 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0255374 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0254106 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0253882 |
| COG5 | component of oligomeric golgi complex 5 | -0.0252567 |
| ARF1 | ADP-ribosylation factor 1 | -0.0251466 |
| CCN2 | cellular communication network factor 2 | -0.0251193 |
| RTN4 | reticulon 4 | -0.0249226 |
| UBC | ubiquitin C | -0.0245035 |
| EPHA5 | EPH receptor A5 | -0.0244491 |
| MATR3 | matrin 3 | -0.0243004 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0241247 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.024028 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0237545 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0236739 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0232596 |
| IL6ST | interleukin 6 signal transducer | -0.0231909 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0231769 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0230211 |
| LDHB | lactate dehydrogenase B | -0.0228676 |
| RPL39 | ribosomal protein L39 | -0.0226996 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0224632 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0224601 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0224586 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0223121 |
| FTL | ferritin, light polypeptide | -0.0221172 |
| HMGA1 | high mobility group AT-hook 1 | -0.022082 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0217097 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0215655 |
| PEG10 | paternally expressed 10 | -0.02137 |
| TMEM123 | transmembrane protein 123 | -0.0212812 |
| WWOX | WW domain containing oxidoreductase | -0.0211019 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0209819 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0208588 |
| GLG1 | golgi glycoprotein 1 | -0.0207724 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0207033 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0206229 |
