| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.337217 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.115254 |
| FMN1 | formin 1 | 0.0686444 |
| CRH | corticotropin releasing hormone | 0.0682156 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0677061 |
| VEGFA | vascular endothelial growth factor A | 0.0667925 |
| RPS12 | ribosomal protein S12 | 0.0620876 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0609827 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0599182 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0587973 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0583308 |
| SEPTIN9 | septin 9 | 0.05798 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0537617 |
| DNMBP | dynamin binding protein | 0.0507823 |
| RPS6 | ribosomal protein S6 | 0.0499048 |
| MYO6 | myosin VI | 0.048919 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0473828 |
| FAM13A | family with sequence similarity 13, member A | 0.04734 |
| PLAT | plasminogen activator, tissue | 0.0453252 |
| B2M | beta-2-microglobulin | 0.0450012 |
| MEF2A | myocyte enhancer factor 2A | 0.0449887 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0438727 |
| MEIS2 | Meis homeobox 2 | 0.0437705 |
| HDGF | hepatoma-derived growth factor | 0.043739 |
| RPL3 | ribosomal protein L3 | 0.0425894 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0421652 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0419115 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0418102 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0417655 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0414084 |
| RPL4 | ribosomal protein L4 | 0.0412653 |
| DST | dystonin | 0.0409726 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0404829 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0404078 |
| ENAH | enabled homolog (Drosophila) | 0.0399679 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0390714 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0378459 |
| SP100 | SP100 nuclear antigen | 0.0374174 |
| ANO6 | anoctamin 6 | 0.0367356 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0350232 |
| RPL7A | ribosomal protein L7a | 0.0348287 |
| HIP1 | huntingtin interacting protein 1 | 0.0347758 |
| MMP2 | matrix metallopeptidase 2 | 0.0343821 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0343564 |
| PLPP1 | phospholipid phosphatase 1 | 0.0333743 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0332793 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0332485 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 0.0331193 |
| RPS3 | ribosomal protein S3 | 0.0326477 |
| CPNE8 | copine VIII | 0.0320696 |
| RPS2 | ribosomal protein S2 | 0.0317602 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0317512 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0316141 |
| SFTPA2 | surfactant protein A2 | 0.0313683 |
| SCG2 | secretogranin II | 0.0311919 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0309574 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0308822 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0307926 |
| ATP13A3 | ATPase type 13A3 | 0.0307442 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.030742 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0307277 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0305134 |
| RPL37 | ribosomal protein L37 | 0.0304949 |
| IFI44L | interferon-induced protein 44-like | 0.0302629 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0302469 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0302435 |
| CTSB | cathepsin B | 0.0301885 |
| RPS17 | ribosomal protein S17 | 0.0300832 |
| COL4A1 | collagen, type IV, alpha 1 | 0.02952 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0293313 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.029159 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0291009 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | 0.0290937 |
| RPS8 | ribosomal protein S8 | 0.0290535 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0290061 |
| RIGI | RNA sensor RIG-I | 0.0289129 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0286465 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0283582 |
| DNM3 | dynamin 3 | 0.0282642 |
| TLK2 | tousled-like kinase 2 | 0.0280815 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0279966 |
| TPM3 | tropomyosin 3 | 0.0279804 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.02796 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0279559 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0278938 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0268195 |
| APP | amyloid beta (A4) precursor protein | 0.0266162 |
| RPL27 | ribosomal protein L27 | 0.0265652 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 0.0264783 |
| DGKH | diacylglycerol kinase, eta | 0.0264574 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.026434 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0260756 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0260467 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0259986 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0258153 |
| PCBP3 | poly(rC) binding protein 3 | 0.0256924 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.025683 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0255021 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0253752 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0252794 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.237151 |
| IGF2 | insulin-like growth factor 2 | -0.228216 |
| TRIB2 | tribbles pseudokinase 2 | -0.0877833 |
| VCL | vinculin | -0.0847296 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0836063 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0764045 |
| VIM | vimentin | -0.0562017 |
| SYT1 | synaptotagmin I | -0.0522977 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0517851 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0502773 |
| TLE4 | transducin-like enhancer of split 4 | -0.0458953 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.045287 |
| PCDH9 | protocadherin 9 | -0.043763 |
| RPL35A | ribosomal protein L35a | -0.0437166 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0435215 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0405785 |
| TMSB10 | thymosin beta 10 | -0.0391883 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0376077 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0374146 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0370658 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0368522 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0357912 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0351226 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.0342468 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0336728 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0324991 |
| LSAMP | limbic system-associated membrane protein | -0.0323919 |
| DACH2 | dachshund family transcription factor 2 | -0.0322299 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0319724 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0313995 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0311708 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0310092 |
| ZNF804A | zinc finger protein 804A | -0.0309102 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0302835 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0301206 |
| NRG1 | neuregulin 1 | -0.0294252 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0292907 |
| CADM2 | cell adhesion molecule 2 | -0.0292096 |
| HDLBP | high density lipoprotein binding protein | -0.0290869 |
| MORF4L2 | mortality factor 4 like 2 | -0.0287796 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0283333 |
| UNC5C | unc-5 homolog C (C. elegans) | -0.0281291 |
| FRMD4A | FERM domain containing 4A | -0.0279983 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0279838 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0279679 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0279582 |
| RPS27A | ribosomal protein S27a | -0.0278802 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.02765 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0274485 |
| DTNA | dystrobrevin, alpha | -0.0274443 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0273648 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0273477 |
| CDC27 | cell division cycle 27 | -0.0270845 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0270258 |
| RNF150 | ring finger protein 150 | -0.0266375 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0265638 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.0265055 |
| EGR1 | early growth response 1 | -0.0262664 |
| ZNF638 | zinc finger protein 638 | -0.0262408 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0254957 |
| CCDC47 | coiled-coil domain containing 47 | -0.025456 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0253688 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0252823 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0252128 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0248658 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0245411 |
| ARF1 | ADP-ribosylation factor 1 | -0.0243483 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0243161 |
| RC3H1 | ring finger and CCCH-type domains 1 | -0.0242645 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0240176 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0240153 |
| KIF21A | kinesin family member 21A | -0.0237799 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.02375 |
| HMGB2 | high mobility group box 2 | -0.0236059 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0235549 |
| AEBP2 | AE binding protein 2 | -0.0232038 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0231561 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0230236 |
| MAPK10 | mitogen-activated protein kinase 10 | -0.0229507 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0229349 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0223268 |
| INTS6 | integrator complex subunit 6 | -0.0222551 |
| COPS2 | COP9 signalosome subunit 2 | -0.0221905 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0221582 |
| CANX | calnexin | -0.0218538 |
| RBM25 | RNA binding motif protein 25 | -0.0217069 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | -0.0216952 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0216711 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0215967 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.021537 |
| WDR26 | WD repeat domain 26 | -0.0215186 |
| LMNA | lamin A/C | -0.0214481 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0213112 |
| RPLP1 | ribosomal protein, large, P1 | -0.0212131 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0212002 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0211905 |
| FGF14 | fibroblast growth factor 14 | -0.0211035 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0210412 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0209795 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0209473 |
