| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.151457 |
| LMO7 | LIM domain 7 | 0.120382 |
| UBC | ubiquitin C | 0.11823 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.117215 |
| FNDC3B | fibronectin type III domain containing 3B | 0.108171 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0974391 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0937948 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0802156 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0757984 |
| EZR | ezrin | 0.0711603 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0662813 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0650393 |
| VEGFA | vascular endothelial growth factor A | 0.062342 |
| CANX | calnexin | 0.062147 |
| CALR | calreticulin | 0.0596402 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0590326 |
| ENO1 | enolase 1, (alpha) | 0.0588452 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0571642 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0554871 |
| TRIM2 | tripartite motif containing 2 | 0.0551214 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0546994 |
| AHNAK | AHNAK nucleoprotein | 0.0544639 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0521828 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0504907 |
| SPATA13 | spermatogenesis associated 13 | 0.0502184 |
| FDPS | farnesyl diphosphate synthase | 0.0499071 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.049009 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.047107 |
| APOL1 | apolipoprotein L, 1 | 0.0457217 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0445214 |
| FNIP1 | folliculin interacting protein 1 | 0.044399 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.044329 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0438683 |
| JUN | jun proto-oncogene | 0.0433209 |
| ANXA2 | annexin A2 | 0.0432905 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0420835 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.041293 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0409833 |
| ANXA1 | annexin A1 | 0.0406937 |
| CDHR2 | cadherin-related family member 2 | 0.0402577 |
| SEC24D | SEC24 family member D | 0.0399556 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0396752 |
| GOLGB1 | golgin B1 | 0.0396218 |
| LDHA | lactate dehydrogenase A | 0.0393687 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0389343 |
| H1-0 | H1.0 linker histone | 0.0388688 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0385681 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.038377 |
| COPA | coatomer protein complex, subunit alpha | 0.0382664 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0377507 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0373875 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0372965 |
| PGK1 | phosphoglycerate kinase 1 | 0.0372096 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0364861 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0364832 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0359716 |
| TMSB4X | thymosin beta 4, X-linked | 0.0353711 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0349927 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0345625 |
| KIF16B | kinesin family member 16B | 0.0344491 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0343336 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0333885 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0333673 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0332485 |
| HDLBP | high density lipoprotein binding protein | 0.0332062 |
| DSPP | dentin sialophosphoprotein | 0.0325551 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.032523 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0322633 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | 0.0312351 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | 0.0306117 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0304631 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0304007 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0300056 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0297331 |
| PMM2 | phosphomannomutase 2 | 0.0294455 |
| TUT7 | terminal uridylyl transferase 7 | 0.0289797 |
| GOLGA4 | golgin A4 | 0.0285759 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0285505 |
| HLA-E | major histocompatibility complex, class I, E | 0.0284731 |
| KLF6 | Kruppel-like factor 6 | 0.0283996 |
| DUSP10 | dual specificity phosphatase 10 | 0.0283269 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.028284 |
| PKM | pyruvate kinase, muscle | 0.0282027 |
| STYXL2 | serine/threonine/tyrosine interacting like 2 | 0.0280081 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0274516 |
| ADM | adrenomedullin | 0.0274184 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0272779 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.027074 |
| MORF4L2 | mortality factor 4 like 2 | 0.0267301 |
| ERBIN | erbb2 interacting protein | 0.0261672 |
| INSIG1 | insulin induced gene 1 | 0.0260943 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0260387 |
| ADIPOR2 | adiponectin receptor 2 | 0.025768 |
| KRT18 | keratin 18, type I | 0.0254923 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0254287 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0251557 |
| ZNF292 | zinc finger protein 292 | 0.025035 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.024982 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0246737 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0242116 |
| Symbol | Name | Standardized Value |
|---|---|---|
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0974462 |
| RPL35A | ribosomal protein L35a | -0.0966395 |
| RUNX1 | runt-related transcription factor 1 | -0.0680971 |
| HLA-B | major histocompatibility complex, class I, B | -0.0668745 |
| RNF43 | ring finger protein 43 | -0.0649558 |
| MEIS2 | Meis homeobox 2 | -0.0641975 |
| RPS6 | ribosomal protein S6 | -0.0614237 |
| B2M | beta-2-microglobulin | -0.0610222 |
| RPLP1 | ribosomal protein, large, P1 | -0.0608701 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0606333 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0583318 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0570136 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0554438 |
| NCKAP5 | NCK-associated protein 5 | -0.0550122 |
| VCL | vinculin | -0.0539841 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0504622 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0503513 |
| EGR1 | early growth response 1 | -0.0490814 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.047463 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0472507 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0461797 |
| STK24 | serine/threonine kinase 24 | -0.0442793 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0430475 |
| RPL34 | ribosomal protein L34 | -0.0428124 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0425604 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.040613 |
| TRERF1 | transcriptional regulating factor 1 | -0.0398748 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0396169 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0368895 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0368074 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0367132 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0364149 |
| TMSB10 | thymosin beta 10 | -0.0362543 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0360651 |
| RIGI | RNA sensor RIG-I | -0.0358225 |
| FOXP1 | forkhead box P1 | -0.0358003 |
| RPS19 | ribosomal protein S19 | -0.0354987 |
| YAP1 | Yes-associated protein 1 | -0.0349302 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0343593 |
| HMGB1 | high mobility group box 1 | -0.0342647 |
| SP100 | SP100 nuclear antigen | -0.033527 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0334018 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0333481 |
| BPTF | bromodomain PHD finger transcription factor | -0.0326492 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.0325731 |
| AHI1 | Abelson helper integration site 1 | -0.0324472 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.031622 |
| PLSCR2 | phospholipid scramblase 2 | -0.0314373 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0313856 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0311313 |
| FUS | FUS RNA binding protein | -0.0309733 |
| DIAPH3 | diaphanous-related formin 3 | -0.0307656 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0307502 |
| HLA-C | major histocompatibility complex, class I, C | -0.0306661 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0306574 |
| RPLP2 | ribosomal protein, large, P2 | -0.0305272 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0303007 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0299205 |
| EPHB2 | EPH receptor B2 | -0.0298487 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -0.0297136 |
| ATP11A | ATPase, class VI, type 11A | -0.0295504 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0294166 |
| TC2N | tandem C2 domains, nuclear | -0.0293084 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0291178 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0289364 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0288371 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0287202 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0285806 |
| RPS29 | ribosomal protein S29 | -0.0281603 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0279633 |
| RPL31 | ribosomal protein L31 | -0.0279265 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.027563 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.027477 |
| PHIP | pleckstrin homology domain interacting protein | -0.0274278 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0271694 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0270918 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0269734 |
| RPS28 | ribosomal protein S28 | -0.0269728 |
| RAD51B | RAD51 paralog B | -0.0266181 |
| VWA8 | von Willebrand factor A domain containing 8 | -0.0265558 |
| TXNIP | thioredoxin interacting protein | -0.0263124 |
| ACTN4 | actinin, alpha 4 | -0.0261224 |
| RPS24 | ribosomal protein S24 | -0.0260069 |
| SAA2 | serum amyloid A2 | -0.0259877 |
| MYO1E | myosin IE | -0.0257883 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0257022 |
| SMYD3 | SET and MYND domain containing 3 | -0.0256627 |
| RBM25 | RNA binding motif protein 25 | -0.0255855 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0255725 |
| CLYBL | citrate lyase beta like | -0.0255592 |
| GUCA1B | guanylate cyclase activator 1B (retina) | -0.0251714 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0251264 |
| RPL36 | ribosomal protein L36 | -0.0250806 |
| NCALD | neurocalcin delta | -0.0250518 |
| RNF213 | ring finger protein 213 | -0.0250069 |
| IL20RA | interleukin 20 receptor, alpha | -0.0248637 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0246642 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0245603 |
| HDAC8 | histone deacetylase 8 | -0.0245103 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0244165 |
