| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Adagrasib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.279686 |
| COL6A3 | collagen, type VI, alpha 3 | 0.207706 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.185671 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.176345 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.155879 |
| CALR | calreticulin | 0.131651 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.128691 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.120687 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0875764 |
| ENO1 | enolase 1, (alpha) | 0.0777625 |
| UBC | ubiquitin C | 0.0748043 |
| LDHA | lactate dehydrogenase A | 0.0709609 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0686762 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0685378 |
| AHNAK | AHNAK nucleoprotein | 0.0641723 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0638558 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0614387 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0595445 |
| RPL3 | ribosomal protein L3 | 0.0576755 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0568006 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0567201 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0543382 |
| APP | amyloid beta (A4) precursor protein | 0.0517356 |
| ATP13A3 | ATPase type 13A3 | 0.0510431 |
| STC1 | stanniocalcin 1 | 0.0499584 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0492526 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0488883 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0472546 |
| INHBA | inhibin, beta A | 0.0470383 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0464762 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0462352 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0453503 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0452445 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0433003 |
| SDC2 | syndecan 2 | 0.0431585 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0424774 |
| TMSB4X | thymosin beta 4, X-linked | 0.0418673 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0406495 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0396899 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.038766 |
| PLEC | plectin | 0.0381526 |
| NAV2 | neuron navigator 2 | 0.0378614 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.037338 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0372748 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0365305 |
| NAV1 | neuron navigator 1 | 0.0360902 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.034979 |
| ARRDC3 | arrestin domain containing 3 | 0.0349743 |
| RPL4 | ribosomal protein L4 | 0.0347394 |
| B2M | beta-2-microglobulin | 0.0336119 |
| STC2 | stanniocalcin 2 | 0.0332092 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0329778 |
| CALU | calumenin | 0.0329258 |
| HLA-A | major histocompatibility complex, class I, A | 0.0324508 |
| TMF1 | TATA element modulatory factor 1 | 0.0323778 |
| TNS1 | tensin 1 | 0.0322756 |
| VMP1 | vacuole membrane protein 1 | 0.0320547 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0315884 |
| RACK1 | receptor for activated C kinase 1 | 0.0315394 |
| MSN | moesin | 0.0314087 |
| CANX | calnexin | 0.0313613 |
| SFTPA2 | surfactant protein A2 | 0.0311684 |
| CTSB | cathepsin B | 0.0302091 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0301792 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0298277 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0296057 |
| IL6 | interleukin 6 | 0.0292559 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0291052 |
| CDH13 | cadherin 13 | 0.0290263 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0288136 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0287065 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0286077 |
| ANXA1 | annexin A1 | 0.0284019 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0282268 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0276716 |
| TPM3 | tropomyosin 3 | 0.0275479 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0273517 |
| ANO6 | anoctamin 6 | 0.0268582 |
| COL3A1 | collagen, type III, alpha 1 | 0.0266314 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0265368 |
| RPS12 | ribosomal protein S12 | 0.0260275 |
| HYOU1 | hypoxia up-regulated 1 | 0.0260151 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0259922 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0258271 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0257122 |
| RND3 | Rho family GTPase 3 | 0.0252736 |
| PKM | pyruvate kinase, muscle | 0.0250525 |
| COPA | coatomer protein complex, subunit alpha | 0.0249734 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.024833 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.024791 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0245728 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0244745 |
| CD44 | CD44 molecule (Indian blood group) | 0.0242223 |
| OPTN | optineurin | 0.0241188 |
| RPS3 | ribosomal protein S3 | 0.0239477 |
| MTSS1 | metastasis suppressor 1 | 0.0237176 |
| DSPP | dentin sialophosphoprotein | 0.0234152 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0233338 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0232296 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0231395 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.197373 |
| FN1 | fibronectin 1 | -0.17748 |
| NDRG1 | N-myc downstream regulated 1 | -0.167631 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.164936 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.110411 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.109785 |
| COL1A1 | collagen, type I, alpha 1 | -0.0943976 |
| TMSB10 | thymosin beta 10 | -0.0894072 |
| RPL35A | ribosomal protein L35a | -0.0876587 |
| MT1X | metallothionein 1X | -0.071716 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0604121 |
| VIM | vimentin | -0.0530257 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0495934 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0486734 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0451912 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0437674 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0432621 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.042395 |
| COL1A2 | collagen, type I, alpha 2 | -0.0418937 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0401521 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0385828 |
| RPS19 | ribosomal protein S19 | -0.0376667 |
| GNAS | GNAS complex locus | -0.0367731 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0363839 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0346094 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0345247 |
| RUNX1 | runt-related transcription factor 1 | -0.0337763 |
| EGR1 | early growth response 1 | -0.0329518 |
| RPLP1 | ribosomal protein, large, P1 | -0.0311671 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0300239 |
| PXDN | peroxidasin | -0.0299511 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0294091 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0292751 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0282881 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0275023 |
| POSTN | periostin, osteoblast specific factor | -0.026848 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0266721 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0265309 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.025753 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0257373 |
| RRBP1 | ribosome binding protein 1 | -0.0255348 |
| PFN1 | profilin 1 | -0.0248776 |
| MAP4 | microtubule-associated protein 4 | -0.0243515 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0242199 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0240327 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0238176 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0235943 |
| NKTR | natural killer cell triggering receptor | -0.0234421 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0234214 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0233877 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0231858 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0229427 |
| GLIS3 | GLIS family zinc finger 3 | -0.0229315 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0224028 |
| RPS20 | ribosomal protein S20 | -0.0223854 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0218358 |
| TMEM165 | transmembrane protein 165 | -0.0218061 |
| PRELID2 | PRELI domain containing 2 | -0.0217074 |
| PRR16 | proline rich 16 | -0.0211643 |
| RPS6 | ribosomal protein S6 | -0.0207755 |
| NREP | neuronal regeneration related protein | -0.0207401 |
| CNTN5 | contactin 5 | -0.0206238 |
| HMGB1 | high mobility group box 1 | -0.0205722 |
| TRAM1 | translocation associated membrane protein 1 | -0.020481 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.020282 |
| RPL32 | ribosomal protein L32 | -0.020092 |
| EHD2 | EH-domain containing 2 | -0.0194364 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0191818 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.0190292 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0189316 |
| COL5A1 | collagen, type V, alpha 1 | -0.0188772 |
| FTL | ferritin, light polypeptide | -0.0188584 |
| TPM4 | tropomyosin 4 | -0.0182473 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0182382 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0181876 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0180191 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0178846 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0175966 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.017373 |
| RPLP2 | ribosomal protein, large, P2 | -0.0170664 |
| RPL34 | ribosomal protein L34 | -0.0169733 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0169142 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0168146 |
| RTN4 | reticulon 4 | -0.0167927 |
| RPS24 | ribosomal protein S24 | -0.0167848 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0167298 |
| RPS21 | ribosomal protein S21 | -0.0166958 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0164166 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0159457 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0159144 |
| SEPTIN7 | septin 7 | -0.0157786 |
| TAPBP | TAP binding protein (tapasin) | -0.0157676 |
| HMGA1 | high mobility group AT-hook 1 | -0.0157158 |
| RPL28 | ribosomal protein L28 | -0.0156631 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.015628 |
| ICAM1 | intercellular adhesion molecule 1 | -0.015624 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0154321 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0153811 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0153049 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0151839 |
