| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Adagrasib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.332056 |
| DSPP | dentin sialophosphoprotein | 0.158199 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.12616 |
| TF | transferrin | 0.099883 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0850942 |
| VEGFA | vascular endothelial growth factor A | 0.0805944 |
| RPS12 | ribosomal protein S12 | 0.0758662 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0718279 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0698759 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0610666 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0574011 |
| RPL3 | ribosomal protein L3 | 0.0523512 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0511288 |
| PEG3 | paternally expressed 3 | 0.0450254 |
| RPS6 | ribosomal protein S6 | 0.0434231 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0424203 |
| RPS3 | ribosomal protein S3 | 0.0417934 |
| RPL4 | ribosomal protein L4 | 0.0413776 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0411224 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0406362 |
| RPL11 | ribosomal protein L11 | 0.0400656 |
| AHSG | alpha-2-HS-glycoprotein | 0.0399055 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0398214 |
| INSIG2 | insulin induced gene 2 | 0.0389022 |
| RPL37A | ribosomal protein L37a | 0.0382256 |
| RPL13A | ribosomal protein L13a | 0.0359337 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.035737 |
| RPL26 | ribosomal protein L26 | 0.0343543 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0342893 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0335469 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0330604 |
| SDC4 | syndecan 4 | 0.0321535 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0319669 |
| EHBP1 | EH domain binding protein 1 | 0.0319417 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0314733 |
| RPL7 | ribosomal protein L7 | 0.0309909 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0309005 |
| CP | ceruloplasmin (ferroxidase) | 0.0307593 |
| RPS17 | ribosomal protein S17 | 0.030507 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0304784 |
| RPL37 | ribosomal protein L37 | 0.0298601 |
| FMNL2 | formin-like 2 | 0.0297537 |
| CPE | carboxypeptidase E | 0.0295301 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0292036 |
| APOA2 | apolipoprotein A-II | 0.0289006 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0289002 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0288231 |
| RPLP0 | ribosomal protein, large, P0 | 0.0285638 |
| GPX4 | glutathione peroxidase 4 | 0.0271817 |
| LYZ | lysozyme | 0.0270381 |
| AFDN | afadin, adherens junction formation factor | 0.0268395 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0266291 |
| LDHA | lactate dehydrogenase A | 0.0259419 |
| RPL27 | ribosomal protein L27 | 0.0257447 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0256302 |
| KIF5B | kinesin family member 5B | 0.0256151 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0255454 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.025516 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0253398 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0250182 |
| TRIM26 | tripartite motif containing 26 | 0.0249696 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0249139 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0248541 |
| RACK1 | receptor for activated C kinase 1 | 0.0247163 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0237148 |
| CRY1 | cryptochrome circadian clock 1 | 0.02365 |
| RPS8 | ribosomal protein S8 | 0.0236479 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0233626 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0229894 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0229363 |
| SFTPA2 | surfactant protein A2 | 0.0224707 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0223945 |
| PAPOLA | poly(A) polymerase alpha | 0.0223928 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0223626 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0220682 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0220325 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.022013 |
| NCKAP1 | NCK-associated protein 1 | 0.0219977 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0218894 |
| RNASET2 | ribonuclease T2 | 0.0216807 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0214882 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0214614 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0214342 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0213561 |
| CHMP4B | charged multivesicular body protein 4B | 0.0210935 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0208609 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0207417 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0204696 |
| KRT18 | keratin 18, type I | 0.0203542 |
| DST | dystonin | 0.0203441 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0202277 |
| TPI1 | triosephosphate isomerase 1 | 0.0202158 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0201798 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0198521 |
| PLIN2 | perilipin 2 | 0.0198124 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0198096 |
| RPL12 | ribosomal protein L12 | 0.0197651 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0197647 |
| RPL18 | ribosomal protein L18 | 0.0196665 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0196588 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.259575 |
| IGF2 | insulin-like growth factor 2 | -0.254445 |
| FN1 | fibronectin 1 | -0.185555 |
| APOB | apolipoprotein B | -0.126323 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.09246 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0770141 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0726272 |
| GPC6 | glypican 6 | -0.0656197 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0653434 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0603063 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0599548 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.058571 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.050719 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0493662 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0488518 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0416059 |
| EGR1 | early growth response 1 | -0.0404633 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0396189 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0376161 |
| RPL35A | ribosomal protein L35a | -0.0365084 |
| RPS27A | ribosomal protein S27a | -0.0359179 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0352686 |
| NDRG1 | N-myc downstream regulated 1 | -0.0349702 |
| INTS6 | integrator complex subunit 6 | -0.034967 |
| VCL | vinculin | -0.0337531 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0334786 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0333711 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0322933 |
| ACTN4 | actinin, alpha 4 | -0.0306132 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0301212 |
| ASPH | aspartate beta-hydroxylase | -0.0295633 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0287971 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.0287581 |
| CRLS1 | cardiolipin synthase 1 | -0.0286941 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0284755 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.0278855 |
| UBC | ubiquitin C | -0.027622 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0274703 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0260495 |
| SMAD3 | SMAD family member 3 | -0.0259185 |
| SVIL | supervillin | -0.0257147 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0251397 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0247259 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.024624 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0245091 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0242903 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.023862 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0233665 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0233433 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0232975 |
| ZNF638 | zinc finger protein 638 | -0.0229882 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0228273 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0223214 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0223149 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0222291 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0220115 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0219814 |
| FAT1 | FAT atypical cadherin 1 | -0.0218143 |
| GLG1 | golgi glycoprotein 1 | -0.0215966 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0214544 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0214179 |
| RUNX1 | runt-related transcription factor 1 | -0.0209733 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0207936 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.020459 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0201946 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0201734 |
| RNF213 | ring finger protein 213 | -0.0201027 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0200601 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0200035 |
| ATRN | attractin | -0.0199412 |
| PTCHD4 | patched domain containing 4 | -0.0198397 |
| ATXN1 | ataxin 1 | -0.0194824 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0194086 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0192875 |
| POTEF | POTE ankyrin domain family, member F | -0.0190916 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0190298 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0189647 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0189508 |
| EXOC6B | exocyst complex component 6B | -0.0187415 |
| ZNF207 | zinc finger protein 207 | -0.0186719 |
| JUN | jun proto-oncogene | -0.018381 |
| SKIL | SKI-like proto-oncogene | -0.0183003 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0181757 |
| ATP11A | ATPase, class VI, type 11A | -0.0180359 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0179631 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0179541 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0178982 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0178512 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0178315 |
| TMSB10 | thymosin beta 10 | -0.0178256 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.01764 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0173806 |
| SP100 | SP100 nuclear antigen | -0.0172686 |
| EXOC4 | exocyst complex component 4 | -0.0172558 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.017119 |
| ITGB5 | integrin, beta 5 | -0.0170916 |
| OSMR | oncostatin M receptor | -0.0169807 |
| GSE1 | Gse1 coiled-coil protein | -0.0168937 |
| FAM135A | family with sequence similarity 135, member A | -0.0168937 |
| CMIP | c-Maf inducing protein | -0.0168326 |
