| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AHNAK | AHNAK nucleoprotein | 0.142426 |
| TMSB4X | thymosin beta 4, X-linked | 0.0955873 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0941802 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0757102 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0709707 |
| ANXA1 | annexin A1 | 0.0641985 |
| PTMA | prothymosin, alpha | 0.0621025 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0566554 |
| ENO1 | enolase 1, (alpha) | 0.0565616 |
| CANX | calnexin | 0.0552154 |
| KRT17 | keratin 17, type I | 0.0503084 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0492464 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0476603 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0458622 |
| CALR | calreticulin | 0.0456001 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0453186 |
| LDHA | lactate dehydrogenase A | 0.0445003 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0407269 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0406556 |
| OGA | O-GlcNAcase | 0.0375706 |
| RPL4 | ribosomal protein L4 | 0.0362782 |
| KRT6A | keratin 6A, type II | 0.0359669 |
| H1-0 | H1.0 linker histone | 0.0358007 |
| SQLE | squalene epoxidase | 0.0355832 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0348606 |
| UBC | ubiquitin C | 0.0347316 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0339592 |
| PGK1 | phosphoglycerate kinase 1 | 0.0327891 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0318628 |
| LMO7 | LIM domain 7 | 0.0312001 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0305561 |
| RPS3 | ribosomal protein S3 | 0.0292067 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0286811 |
| CAVIN1 | caveolae associated protein 1 | 0.0285862 |
| HLA-E | major histocompatibility complex, class I, E | 0.0280153 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0278437 |
| ANLN | anillin, actin binding protein | 0.0277853 |
| EZR | ezrin | 0.0276506 |
| RPL3 | ribosomal protein L3 | 0.0269731 |
| APP | amyloid beta (A4) precursor protein | 0.0266244 |
| RPL14 | ribosomal protein L14 | 0.0260341 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0258639 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0256408 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0251822 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0246551 |
| HDLBP | high density lipoprotein binding protein | 0.0246185 |
| CEP250 | centrosomal protein 250kDa | 0.0245713 |
| MKI67 | marker of proliferation Ki-67 | 0.0244041 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0241359 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.02336 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0232363 |
| CUL4B | cullin 4B | 0.0229597 |
| RPL13A | ribosomal protein L13a | 0.0225275 |
| ARRDC3 | arrestin domain containing 3 | 0.021776 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0216909 |
| RAI14 | retinoic acid induced 14 | 0.0207847 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0203523 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0203122 |
| MEGF6 | multiple EGF-like-domains 6 | 0.019723 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0193984 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0193703 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.019341 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.019053 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0184966 |
| PLEC | plectin | 0.018354 |
| EMP1 | epithelial membrane protein 1 | 0.0183303 |
| RPS27A | ribosomal protein S27a | 0.018269 |
| ANXA2 | annexin A2 | 0.018255 |
| SDC4 | syndecan 4 | 0.0180082 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0177595 |
| TPM3 | tropomyosin 3 | 0.0177181 |
| CALU | calumenin | 0.0176825 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0176579 |
| TMF1 | TATA element modulatory factor 1 | 0.0173665 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0173435 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0172955 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0172425 |
| RASA3 | RAS p21 protein activator 3 | 0.017051 |
| RAI1 | retinoic acid induced 1 | 0.0166138 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | 0.0166102 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0164218 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0162163 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0161644 |
| DSPP | dentin sialophosphoprotein | 0.0160508 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0160203 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0159004 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.015847 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0154834 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0154778 |
| SERINC1 | serine incorporator 1 | 0.0154596 |
| HDGF | hepatoma-derived growth factor | 0.0153213 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0152523 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0149936 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0149258 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0148646 |
| KRT14 | keratin 14, type I | 0.0147239 |
| DIDO1 | death inducer-obliterator 1 | 0.0146921 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0146177 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.014458 |
| SQSTM1 | sequestosome 1 | 0.0143881 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.173401 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.098864 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0951914 |
| IGF2 | insulin-like growth factor 2 | -0.0634654 |
| DPYD | dihydropyrimidine dehydrogenase | -0.06253 |
| EGR1 | early growth response 1 | -0.0596701 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.058762 |
| FOXO1 | forkhead box O1 | -0.0581591 |
| PODXL | podocalyxin-like | -0.052286 |
| LAMA5 | laminin, alpha 5 | -0.0493524 |
| FOSL1 | FOS-like antigen 1 | -0.0484786 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0463461 |
| POTEF | POTE ankyrin domain family, member F | -0.0433243 |
| MT2A | metallothionein 2A | -0.0432239 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0432178 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0427737 |
| MSN | moesin | -0.042693 |
| RPS21 | ribosomal protein S21 | -0.0386084 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0385702 |
| BCL2L1 | BCL2-like 1 | -0.0365132 |
| HLA-B | major histocompatibility complex, class I, B | -0.0359084 |
| RIN2 | Ras and Rab interactor 2 | -0.0349267 |
| CD44 | CD44 molecule (Indian blood group) | -0.0346774 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0346762 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0344629 |
| ACTN4 | actinin, alpha 4 | -0.0342077 |
| OSMR | oncostatin M receptor | -0.0337482 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0329726 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0325924 |
| JMJD1C | jumonji domain containing 1C | -0.0323312 |
| TXNIP | thioredoxin interacting protein | -0.0321834 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0318285 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0314967 |
| RPL35A | ribosomal protein L35a | -0.0311899 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0303328 |
| LUZP1 | leucine zipper protein 1 | -0.0294422 |
| RIGI | RNA sensor RIG-I | -0.0293823 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0290817 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0287545 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0285256 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.027907 |
| FOXP1 | forkhead box P1 | -0.0273701 |
| ITGA6 | integrin, alpha 6 | -0.0272033 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0271854 |
| EFHD2 | EF-hand domain family, member D2 | -0.0270611 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0270256 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.026768 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0264345 |
| GNAS | GNAS complex locus | -0.0263592 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.026278 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0261602 |
| RASAL2 | RAS protein activator like 2 | -0.0250528 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0249692 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0249569 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0248745 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0248544 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0244315 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -0.0242752 |
| MYADM | myeloid-associated differentiation marker | -0.0242591 |
| RPS13 | ribosomal protein S13 | -0.0241099 |
| TMSB10 | thymosin beta 10 | -0.024029 |
| PLS3 | plastin 3 | -0.0240275 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0238813 |
| CMIP | c-Maf inducing protein | -0.0238446 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0235538 |
| HMGA1 | high mobility group AT-hook 1 | -0.0232605 |
| B2M | beta-2-microglobulin | -0.0232139 |
| GRB10 | growth factor receptor-bound protein 10 | -0.023195 |
| TAPBP | TAP binding protein (tapasin) | -0.0230536 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0225766 |
| ITGB4 | integrin, beta 4 | -0.022571 |
| LRRC8A | leucine rich repeat containing 8 family, member A | -0.0222663 |
| SULF2 | sulfatase 2 | -0.022206 |
| PFN1 | profilin 1 | -0.0219375 |
| NECTIN1 | nectin cell adhesion molecule 1 | -0.0218595 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0216265 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0214955 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0214864 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0212577 |
| TGM2 | transglutaminase 2 | -0.021222 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0211586 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0210973 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0209785 |
| SULF1 | sulfatase 1 | -0.0209729 |
| RPS6 | ribosomal protein S6 | -0.0206446 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0206137 |
| IFI44L | interferon-induced protein 44-like | -0.0205741 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.0205418 |
| CLIC4 | chloride intracellular channel 4 | -0.0201902 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0200812 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0200206 |
| DUSP5 | dual specificity phosphatase 5 | -0.0199697 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.01967 |
| NEK7 | NIMA-related kinase 7 | -0.0196468 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.019269 |
| IFI44 | interferon-induced protein 44 | -0.0190625 |
| RTN4 | reticulon 4 | -0.018853 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0187846 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.018541 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0184231 |
