| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 0.416829 |
| KRT18 | keratin 18, type I | 0.116041 |
| VEGFA | vascular endothelial growth factor A | 0.0921326 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0672962 |
| ANXA1 | annexin A1 | 0.0592992 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0542431 |
| B2M | beta-2-microglobulin | 0.0528885 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0522953 |
| TMSB4X | thymosin beta 4, X-linked | 0.0505019 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0494964 |
| DSPP | dentin sialophosphoprotein | 0.0472811 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0449795 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0428008 |
| TMF1 | TATA element modulatory factor 1 | 0.0409122 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0385428 |
| FAM13A | family with sequence similarity 13, member A | 0.0365269 |
| RPS3 | ribosomal protein S3 | 0.0364607 |
| RPS12 | ribosomal protein S12 | 0.0360336 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0355724 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0332557 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0332046 |
| RPL4 | ribosomal protein L4 | 0.0325264 |
| SLK | STE20-like kinase | 0.0324151 |
| FTL | ferritin, light polypeptide | 0.0319943 |
| HLA-A | major histocompatibility complex, class I, A | 0.0314475 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0313745 |
| KRT19 | keratin 19, type I | 0.0312092 |
| PGK1 | phosphoglycerate kinase 1 | 0.0305138 |
| LCN2 | lipocalin 2 | 0.0304605 |
| LAMB3 | laminin, beta 3 | 0.0302525 |
| DSTN | destrin (actin depolymerizing factor) | 0.0295428 |
| SET | SET nuclear proto-oncogene | 0.0291887 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0290567 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0289506 |
| SLTM | SAFB-like, transcription modulator | 0.0277979 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0275956 |
| RPS17 | ribosomal protein S17 | 0.027455 |
| RPL3 | ribosomal protein L3 | 0.0271714 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.027087 |
| SFTPA2 | surfactant protein A2 | 0.0267354 |
| LIMA1 | LIM domain and actin binding 1 | 0.0260276 |
| CLINT1 | clathrin interactor 1 | 0.0256119 |
| GOLGA4 | golgin A4 | 0.025388 |
| HDAC9 | histone deacetylase 9 | 0.0252769 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0248709 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0248107 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0247863 |
| LIPH | lipase, member H | 0.0247194 |
| MCU | mitochondrial calcium uniporter | 0.0245126 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0243814 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.024246 |
| HDGF | hepatoma-derived growth factor | 0.0242243 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0240787 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0240498 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.023516 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0234068 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0227203 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0223607 |
| ATF4 | activating transcription factor 4 | 0.0223277 |
| PMM2 | phosphomannomutase 2 | 0.0214985 |
| RNF145 | ring finger protein 145 | 0.0214523 |
| TMC5 | transmembrane channel-like 5 | 0.0207947 |
| ANXA11 | annexin A11 | 0.0205995 |
| ANXA3 | annexin A3 | 0.0205329 |
| RPL11 | ribosomal protein L11 | 0.0199971 |
| SNX9 | sorting nexin 9 | 0.0198914 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0196827 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0196789 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0193998 |
| OPTN | optineurin | 0.019208 |
| GOLGB1 | golgin B1 | 0.0190768 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0189895 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0188445 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0187965 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0187318 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0183976 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0182625 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0181443 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0181086 |
| RPS2 | ribosomal protein S2 | 0.018045 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0177115 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0175943 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0174837 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0174438 |
| TPM3 | tropomyosin 3 | 0.017329 |
| NCKAP1 | NCK-associated protein 1 | 0.0172595 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0171702 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.0169835 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0169458 |
| APOL1 | apolipoprotein L, 1 | 0.0169326 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0167185 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0166774 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0166247 |
| GDA | guanine deaminase | 0.0166114 |
| TFF2 | trefoil factor 2 | 0.016606 |
| ITGA6 | integrin, alpha 6 | 0.0165753 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0165545 |
| AREG | amphiregulin | 0.0164194 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0163982 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0163696 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GMDS | GDP-mannose 4,6-dehydratase | -0.187472 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.176185 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.139961 |
| TMSB10 | thymosin beta 10 | -0.119599 |
| RPL35A | ribosomal protein L35a | -0.0979212 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0941059 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0937316 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0805437 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0623374 |
| AGR2 | anterior gradient 2 | -0.0597385 |
| ACTN4 | actinin, alpha 4 | -0.059378 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0593208 |
| RPLP1 | ribosomal protein, large, P1 | -0.055552 |
| AHR | aryl hydrocarbon receptor | -0.0553186 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0542821 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0501279 |
| GNAS | GNAS complex locus | -0.0498598 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0493556 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.049173 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0490802 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0474748 |
| RNF213 | ring finger protein 213 | -0.0468772 |
| RUNX1 | runt-related transcription factor 1 | -0.0466564 |
| FAT1 | FAT atypical cadherin 1 | -0.0458107 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0454513 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0440894 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0439047 |
| TMEM123 | transmembrane protein 123 | -0.0431928 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0428439 |
| RTN3 | reticulon 3 | -0.0424684 |
| SPIDR | scaffolding protein involved in DNA repair | -0.042452 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0423976 |
| ITGB4 | integrin, beta 4 | -0.04107 |
| PHF14 | PHD finger protein 14 | -0.0407899 |
| ATXN1 | ataxin 1 | -0.0397179 |
| RPS27A | ribosomal protein S27a | -0.0389822 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0378969 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.037084 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0366513 |
| NCOA7 | nuclear receptor coactivator 7 | -0.036477 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0364593 |
| RPS19 | ribosomal protein S19 | -0.0362223 |
| RPS24 | ribosomal protein S24 | -0.0360193 |
| CANX | calnexin | -0.0358458 |
| TFRC | transferrin receptor | -0.0352464 |
| COBL | cordon-bleu WH2 repeat protein | -0.0341362 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0340423 |
| PTMA | prothymosin, alpha | -0.0340131 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0339668 |
| H1-0 | H1.0 linker histone | -0.0334336 |
| HLA-C | major histocompatibility complex, class I, C | -0.0332369 |
| INTS6 | integrator complex subunit 6 | -0.0324735 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0324074 |
| UBC | ubiquitin C | -0.0321644 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0319555 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0318381 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0316585 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | -0.0314147 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0311777 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0311233 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0308172 |
| WWOX | WW domain containing oxidoreductase | -0.0307585 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.0299912 |
| NF1 | neurofibromin 1 | -0.0297657 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0297558 |
| HMGB1 | high mobility group box 1 | -0.0295103 |
| ANXA2 | annexin A2 | -0.0294572 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0294385 |
| FUS | FUS RNA binding protein | -0.0291945 |
| RAD51B | RAD51 paralog B | -0.0290406 |
| BPTF | bromodomain PHD finger transcription factor | -0.0289089 |
| EHBP1 | EH domain binding protein 1 | -0.0286637 |
| GPHN | gephyrin | -0.0285992 |
| CDK6 | cyclin-dependent kinase 6 | -0.0284046 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0280266 |
| POF1B | premature ovarian failure, 1B | -0.0272332 |
| PCBP2 | poly(rC) binding protein 2 | -0.0272269 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.0271731 |
| ZNF207 | zinc finger protein 207 | -0.0269555 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0269484 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0267736 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0265777 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0262742 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.026272 |
| SMC4 | structural maintenance of chromosomes 4 | -0.026265 |
| EXOC4 | exocyst complex component 4 | -0.0262431 |
| PKP4 | plakophilin 4 | -0.0259782 |
| RNF216 | ring finger protein 216 | -0.0258517 |
| ATF5 | activating transcription factor 5 | -0.025686 |
| WDR45B | WD repeat domain 45B | -0.0254435 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0254139 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0254082 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0252711 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0252434 |
| DIAPH2 | diaphanous-related formin 2 | -0.0252237 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0252125 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -0.025159 |
| ADIPOR2 | adiponectin receptor 2 | -0.025125 |
| CCDC146 | coiled-coil domain containing 146 | -0.0249198 |
| GLG1 | golgi glycoprotein 1 | -0.0249111 |
