| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.118051 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.11487 |
| FAT1 | FAT atypical cadherin 1 | 0.113241 |
| KRT18 | keratin 18, type I | 0.0965402 |
| LMO7 | LIM domain 7 | 0.0925213 |
| VEGFA | vascular endothelial growth factor A | 0.0837814 |
| DSPP | dentin sialophosphoprotein | 0.0789136 |
| RPS12 | ribosomal protein S12 | 0.0764738 |
| PTMA | prothymosin, alpha | 0.0745912 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0697924 |
| RPL3 | ribosomal protein L3 | 0.0682935 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0551057 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0502884 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0498864 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0498696 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0496547 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0495553 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0476211 |
| TMSB4X | thymosin beta 4, X-linked | 0.0473715 |
| RPL4 | ribosomal protein L4 | 0.0460202 |
| ASPH | aspartate beta-hydroxylase | 0.044233 |
| LDHA | lactate dehydrogenase A | 0.0440211 |
| AHNAK | AHNAK nucleoprotein | 0.0425231 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0399886 |
| TPM3 | tropomyosin 3 | 0.0397586 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0394709 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0385243 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0381546 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0368938 |
| MYO5B | myosin VB | 0.0346828 |
| EREG | epiregulin | 0.0341364 |
| RPS3 | ribosomal protein S3 | 0.0328978 |
| TMF1 | TATA element modulatory factor 1 | 0.0323511 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.032047 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0319875 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0319839 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0314266 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0312138 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.031184 |
| FLNB | filamin B, beta | 0.031045 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0308802 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0307799 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0294372 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0294068 |
| UBC | ubiquitin C | 0.0289188 |
| CALR | calreticulin | 0.0286904 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0286872 |
| KRT8 | keratin 8, type II | 0.0283485 |
| RPS2 | ribosomal protein S2 | 0.0279043 |
| FAM13A | family with sequence similarity 13, member A | 0.0279013 |
| RPL37A | ribosomal protein L37a | 0.0278091 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0277947 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0274788 |
| CCNY | cyclin Y | 0.0269122 |
| MCL1 | myeloid cell leukemia 1 | 0.0266332 |
| RPS18 | ribosomal protein S18 | 0.0258237 |
| LAMC2 | laminin, gamma 2 | 0.025576 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0251352 |
| MUC13 | mucin 13, cell surface associated | 0.0248339 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0247813 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0241234 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.024043 |
| HDGF | hepatoma-derived growth factor | 0.023766 |
| B2M | beta-2-microglobulin | 0.0237527 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0232176 |
| PNN | pinin, desmosome associated protein | 0.0230013 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0228116 |
| RNF217 | ring finger protein 217 | 0.0227778 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0227416 |
| LAMB3 | laminin, beta 3 | 0.0227016 |
| PGK1 | phosphoglycerate kinase 1 | 0.0225345 |
| RPS27A | ribosomal protein S27a | 0.0224251 |
| RPL18 | ribosomal protein L18 | 0.0223931 |
| SLK | STE20-like kinase | 0.022147 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0221094 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0219831 |
| EPCAM | epithelial cell adhesion molecule | 0.0218571 |
| RPS17 | ribosomal protein S17 | 0.021759 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0215443 |
| SET | SET nuclear proto-oncogene | 0.0214309 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0213611 |
| ADD3 | adducin 3 (gamma) | 0.0212432 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0211527 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0211099 |
| NCKAP1 | NCK-associated protein 1 | 0.0206176 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0203724 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.0201859 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0200611 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0199927 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0199407 |
| SLTM | SAFB-like, transcription modulator | 0.0198762 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0197442 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0197116 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0196235 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0195342 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0193845 |
| RPL14 | ribosomal protein L14 | 0.0193034 |
| APP | amyloid beta (A4) precursor protein | 0.0188463 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0186129 |
| TFF1 | trefoil factor 1 | 0.0185382 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.253917 |
| NPSR1 | neuropeptide S receptor 1 | -0.135837 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.128937 |
| RPL35A | ribosomal protein L35a | -0.0885161 |
| TMSB10 | thymosin beta 10 | -0.0845571 |
| GPHN | gephyrin | -0.0821015 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0804815 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0768267 |
| TNS4 | tensin 4 | -0.0762113 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0713157 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0674863 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0669853 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0654375 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.058946 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0576552 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0562912 |
| RPLP1 | ribosomal protein, large, P1 | -0.0527517 |
| VCL | vinculin | -0.0520475 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0502179 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0484356 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0471126 |
| RNF43 | ring finger protein 43 | -0.0457356 |
| EGR1 | early growth response 1 | -0.0452158 |
| FHIT | fragile histidine triad | -0.0394755 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.037651 |
| ACTN4 | actinin, alpha 4 | -0.0365101 |
| RPLP0 | ribosomal protein, large, P0 | -0.0358263 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.035755 |
| AGR2 | anterior gradient 2 | -0.0356043 |
| H1-0 | H1.0 linker histone | -0.0353601 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0345727 |
| FOXP1 | forkhead box P1 | -0.0340827 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0340023 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0329429 |
| HMGA1 | high mobility group AT-hook 1 | -0.0328145 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0322444 |
| GNAS | GNAS complex locus | -0.0307054 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.030289 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0294585 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0294299 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0294123 |
| HMGB1 | high mobility group box 1 | -0.0280951 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0279511 |
| RPL34 | ribosomal protein L34 | -0.0270578 |
| TRIM2 | tripartite motif containing 2 | -0.0268772 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0268123 |
| NFIA | nuclear factor I/A | -0.0268055 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0267187 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0264993 |
| ITGB4 | integrin, beta 4 | -0.0264207 |
| INSIG1 | insulin induced gene 1 | -0.0263262 |
| ABLIM1 | actin binding LIM protein 1 | -0.0258897 |
| MAP4 | microtubule-associated protein 4 | -0.0255979 |
| PRSS3 | protease, serine, 3 | -0.0253457 |
| RPS6 | ribosomal protein S6 | -0.0252487 |
| CCND1 | cyclin D1 | -0.0250116 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0247911 |
| FTL | ferritin, light polypeptide | -0.0240136 |
| ARF1 | ADP-ribosylation factor 1 | -0.0239031 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0237128 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0235703 |
| POTEF | POTE ankyrin domain family, member F | -0.0234783 |
| GLG1 | golgi glycoprotein 1 | -0.0233763 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0229418 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0226009 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0224859 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0223378 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.022233 |
| RAB10 | RAB10, member RAS oncogene family | -0.0215768 |
| CADPS | Ca++-dependent secretion activator | -0.0215347 |
| RPL32 | ribosomal protein L32 | -0.021316 |
| MLEC | malectin | -0.0213114 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0212676 |
| PKP4 | plakophilin 4 | -0.0210143 |
| RTN3 | reticulon 3 | -0.0209962 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0205797 |
| NHSL1 | NHS-like 1 | -0.0205752 |
| PCDHB16 | protocadherin beta 16 | -0.0204151 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0203136 |
| RPS24 | ribosomal protein S24 | -0.0203129 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0202548 |
| RPL28 | ribosomal protein L28 | -0.0201787 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0201222 |
| ANXA2 | annexin A2 | -0.020069 |
| ONECUT3 | one cut homeobox 3 | -0.0198755 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | -0.0198636 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0196821 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0196672 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0196639 |
| RPS19 | ribosomal protein S19 | -0.0196397 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.019636 |
| PKP2 | plakophilin 2 | -0.0194994 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0194302 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0191134 |
| FOSL1 | FOS-like antigen 1 | -0.0190994 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0190924 |
| MECOM | MDS1 and EVI1 complex locus | -0.0190669 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0189167 |
| TMEM123 | transmembrane protein 123 | -0.0188743 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0188541 |
