Adagrasib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adagrasib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adagrasib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.0995646
AHNAK AHNAK nucleoprotein 0.0975791
COL5A2 collagen, type V, alpha 2 0.0863294
EGFR epidermal growth factor receptor 0.0851505
DST dystonin 0.0806345
CENPF centromere protein F, 350/400kDa 0.0803712
EPHA4 EPH receptor A4 0.0731776
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0663379
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0579112
APOLD1 apolipoprotein L domain containing 1 0.0578009
TMSB4X thymosin beta 4, X-linked 0.0571674
MBNL2 muscleblind-like splicing regulator 2 0.0546337
FNIP1 folliculin interacting protein 1 0.0542395
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0508614
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0497827
CANX calnexin 0.049743
DLG1 discs, large homolog 1 (Drosophila) 0.0487263
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.048499
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0484524
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0478576
MKI67 marker of proliferation Ki-67 0.044797
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.044667
LDHA lactate dehydrogenase A 0.0444577
TP63 tumor protein p63 0.0440447
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0432271
RAI1 retinoic acid induced 1 0.0421947
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0421576
MB21D2 Mab-21 domain containing 2 0.0416396
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0409693
AHNAK2 AHNAK nucleoprotein 2 0.040026
MBD5 methyl-CpG binding domain protein 5 0.0399227
HDLBP high density lipoprotein binding protein 0.0396793
EFNA5 ephrin-A5 0.0390166
MYOF myoferlin 0.038727
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0380008
TNS3 tensin 3 0.0370803
TRIO trio Rho guanine nucleotide exchange factor 0.0367493
PLK2 polo-like kinase 2 0.0364202
RUNX1 runt-related transcription factor 1 0.0362538
KMT2C lysine (K)-specific methyltransferase 2C 0.035663
SLC38A2 solute carrier family 38, member 2 0.0353906
EPB41 erythrocyte membrane protein band 4.1 0.0351554
CSDE1 cold shock domain containing E1, RNA-binding 0.0337752
RPL4 ribosomal protein L4 0.0331318
ANKRD12 ankyrin repeat domain 12 0.0331127
DENND5B DENN/MADD domain containing 5B 0.0328725
LYST lysosomal trafficking regulator 0.032514
TTC3 tetratricopeptide repeat domain 3 0.031964
AKAP9 A kinase (PRKA) anchor protein 9 0.0318814
EEF2 eukaryotic translation elongation factor 2 0.0318437
ANLN anillin, actin binding protein 0.0317846
BPTF bromodomain PHD finger transcription factor 0.0314101
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0313057
CD109 CD109 molecule 0.0311564
ENO2 enolase 2 (gamma, neuronal) 0.0311505
PTPRF protein tyrosine phosphatase, receptor type, F 0.0307167
DPYD dihydropyrimidine dehydrogenase 0.0299223
ANKRD50 ankyrin repeat domain 50 0.0296861
BABAM2 BRISC and BRCA1 A complex member 2 0.0289954
PHF3 PHD finger protein 3 0.0287712
SOD2 superoxide dismutase 2, mitochondrial 0.0285765
RPL13A ribosomal protein L13a 0.0281808
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0279347
SMYD3 SET and MYND domain containing 3 0.0278705
BCAS3 breast carcinoma amplified sequence 3 0.0278189
CDK19 cyclin-dependent kinase 19 0.0277341
ADAR adenosine deaminase, RNA-specific 0.0276067
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0273514
TRERF1 transcriptional regulating factor 1 0.0271489
CEP350 centrosomal protein 350kDa 0.0269815
RPS3 ribosomal protein S3 0.0265435
MAP4 microtubule-associated protein 4 0.0259763
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0259674
TPI1 triosephosphate isomerase 1 0.0259659
ANXA1 annexin A1 0.0259252
RPS8 ribosomal protein S8 0.0257979
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0255711
HDAC9 histone deacetylase 9 0.0254857
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0254387
YEATS2 YEATS domain containing 2 0.0251203
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0251178
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0248676
CAVIN1 caveolae associated protein 1 0.0243421
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0242612
PGK1 phosphoglycerate kinase 1 0.0240996
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0238329
EXOC4 exocyst complex component 4 0.023803
EHBP1 EH domain binding protein 1 0.023761
PARP14 poly (ADP-ribose) polymerase family, member 14 0.023691
SFTPA2 surfactant protein A2 0.0232924
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0230174
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0230062
SERINC1 serine incorporator 1 0.0228883
RACK1 receptor for activated C kinase 1 0.0222952
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0222093
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0221092
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0219912
SYT1 synaptotagmin I 0.0218814
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0218205
RPL7A ribosomal protein L7a 0.0215295

decreased expression

Symbol Name Standardized Value
TM4SF1 transmembrane 4 L six family member 1 -0.15791
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.147148
FMNL2 formin-like 2 -0.140045
CAPRIN2 caprin family member 2 -0.131968
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.117723
ERRFI1 ERBB receptor feedback inhibitor 1 -0.106697
EGR1 early growth response 1 -0.102246
KMT2E lysine (K)-specific methyltransferase 2E -0.101494
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0957675
RAB7A RAB7A, member RAS oncogene family -0.0951459
MT2A metallothionein 2A -0.0930132
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.088421
TMSB10 thymosin beta 10 -0.0867624
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0785663
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0756914
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0701638
WWTR1 WW domain containing transcription regulator 1 -0.0693361
CD44 CD44 molecule (Indian blood group) -0.068787
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0676455
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0665349
PDE10A phosphodiesterase 10A -0.0657066
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0636127
JUN jun proto-oncogene -0.0616808
NT5E 5'-nucleotidase, ecto (CD73) -0.0609015
FTH1 ferritin, heavy polypeptide 1 -0.0608523
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0607265
FOSL1 FOS-like antigen 1 -0.0601578
PSD3 pleckstrin and Sec7 domain containing 3 -0.057054
HMGA1 high mobility group AT-hook 1 -0.0549359
NPAS2 neuronal PAS domain protein 2 -0.0539855
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0538677
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0530264
BCAR3 breast cancer anti-estrogen resistance 3 -0.0522481
TOP1 topoisomerase (DNA) I -0.0519069
SPRY4 sprouty homolog 4 (Drosophila) -0.0518867
GCLM glutamate-cysteine ligase, modifier subunit -0.0512663
FLNB filamin B, beta -0.0490266
SDK1 sidekick cell adhesion molecule 1 -0.0480719
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0477226
ARHGAP5 Rho GTPase activating protein 5 -0.0473918
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0468969
TGM2 transglutaminase 2 -0.0467284
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0463675
OSBPL8 oxysterol binding protein-like 8 -0.0458095
LOC112694756 uncharaterized LOC112694756 -0.0446187
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0442988
POTEF POTE ankyrin domain family, member F -0.0441142
HLA-B major histocompatibility complex, class I, B -0.044009
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0438344
MCTP1 multiple C2 domains, transmembrane 1 -0.0436941
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0433469
PYGL phosphorylase, glycogen, liver -0.0431242
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0423463
PTK2 protein tyrosine kinase 2 -0.0422424
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0416284
NUP58 nucleoporin 58 -0.041619
WSB1 WD repeat and SOCS box containing 1 -0.0413985
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0411364
CADM2 cell adhesion molecule 2 -0.0403576
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0402672
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0400063
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0397136
RAP2B RAP2B, member of RAS oncogene family -0.0393623
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0384273
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0380449
MCL1 myeloid cell leukemia 1 -0.0377294
UBC ubiquitin C -0.037702
EREG epiregulin -0.0373676
JMJD1C jumonji domain containing 1C -0.0371633
IARS1 isoleucyl-tRNA synthetase 1 -0.0368974
VMP1 vacuole membrane protein 1 -0.0367232
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0365841
TMEM41B transmembrane protein 41B -0.0365663
TFRC transferrin receptor -0.0361498
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0360946
GLS2 glutaminase 2 (liver, mitochondrial) -0.035856
TSC22D1 TSC22 domain family, member 1 -0.0358093
ZEB1 zinc finger E-box binding homeobox 1 -0.0356928
SPAG9 sperm associated antigen 9 -0.035421
THSD4 thrombospondin, type I, domain containing 4 -0.0347881
NIBAN2 niban apoptosis regulator 2 -0.0346218
ADAM17 ADAM metallopeptidase domain 17 -0.034205
APP amyloid beta (A4) precursor protein -0.0341408
SRPK2 SRSF protein kinase 2 -0.0341278
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0338725
RPL35A ribosomal protein L35a -0.0335991
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0332912
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0331507
CMIP c-Maf inducing protein -0.0331476
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0324285
PKM pyruvate kinase, muscle -0.0316866
ECE1 endothelin converting enzyme 1 -0.0311468
SNX14 sorting nexin 14 -0.0311256
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0309259
EMP1 epithelial membrane protein 1 -0.0306052
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0305913
NHSL1 NHS-like 1 -0.0304397
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0304134
ESYT2 extended synaptotagmin-like protein 2 -0.0301416
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0298219