| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.197343 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.146761 |
| LAMC2 | laminin, gamma 2 | 0.110237 |
| UBC | ubiquitin C | 0.0971542 |
| LDHA | lactate dehydrogenase A | 0.0952494 |
| TOP1 | topoisomerase (DNA) I | 0.0892578 |
| DSPP | dentin sialophosphoprotein | 0.0855093 |
| SLTM | SAFB-like, transcription modulator | 0.0844284 |
| CES1 | carboxylesterase 1 | 0.0819517 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0812227 |
| MCL1 | myeloid cell leukemia 1 | 0.0802996 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0795193 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0691885 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0691835 |
| FAM13A | family with sequence similarity 13, member A | 0.0679841 |
| LMO7 | LIM domain 7 | 0.0642297 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0638286 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0626953 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0625789 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0609776 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0604933 |
| MKI67 | marker of proliferation Ki-67 | 0.0598429 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.058182 |
| RPL4 | ribosomal protein L4 | 0.0571217 |
| GRAMD1B | GRAM domain containing 1B | 0.0567662 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0563268 |
| RPS3 | ribosomal protein S3 | 0.0562936 |
| LAMB3 | laminin, beta 3 | 0.0547151 |
| AHNAK | AHNAK nucleoprotein | 0.0537791 |
| ENO1 | enolase 1, (alpha) | 0.05298 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0522008 |
| KRT18 | keratin 18, type I | 0.0498208 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0493798 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0491303 |
| HYOU1 | hypoxia up-regulated 1 | 0.0481229 |
| LAMA4 | laminin, alpha 4 | 0.0476421 |
| PGK1 | phosphoglycerate kinase 1 | 0.0473081 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0472729 |
| ARRDC3 | arrestin domain containing 3 | 0.0471023 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0466175 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0451098 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0449162 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0447991 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0442327 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0428683 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0426016 |
| SPAG9 | sperm associated antigen 9 | 0.042122 |
| RPL3 | ribosomal protein L3 | 0.0415574 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0414784 |
| CANX | calnexin | 0.0399794 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0390906 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0389077 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0388228 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0387166 |
| TPM3 | tropomyosin 3 | 0.0386198 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0382959 |
| ANO6 | anoctamin 6 | 0.0379744 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0369694 |
| PAPOLA | poly(A) polymerase alpha | 0.0365904 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0361749 |
| CALR | calreticulin | 0.0357768 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0356768 |
| NCKAP1 | NCK-associated protein 1 | 0.0351862 |
| OGA | O-GlcNAcase | 0.0347428 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0344134 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0343758 |
| PLEC | plectin | 0.0335541 |
| ATP13A3 | ATPase type 13A3 | 0.0331103 |
| GOLGB1 | golgin B1 | 0.0331014 |
| TES | testin LIM domain protein | 0.0329802 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0328376 |
| RNF145 | ring finger protein 145 | 0.032657 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0325079 |
| RPS12 | ribosomal protein S12 | 0.0322629 |
| VMP1 | vacuole membrane protein 1 | 0.0322271 |
| TMF1 | TATA element modulatory factor 1 | 0.0321607 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0312124 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0306262 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0304595 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0300449 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0297551 |
| ENSA | endosulfine alpha | 0.0296195 |
| HDLBP | high density lipoprotein binding protein | 0.0294737 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0291967 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0291052 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0289249 |
| PYGL | phosphorylase, glycogen, liver | 0.0287143 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.028141 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0278869 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0272917 |
| FNIP1 | folliculin interacting protein 1 | 0.0271951 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.026812 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0262807 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0261962 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0259965 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0256921 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0254249 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0252907 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0252271 |
| SEPTIN10 | septin 10 | 0.0250723 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.180837 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.169757 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.154483 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.123288 |
| RPL35A | ribosomal protein L35a | -0.114172 |
| EGR1 | early growth response 1 | -0.107424 |
| NDRG1 | N-myc downstream regulated 1 | -0.106757 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0800577 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0717908 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0698969 |
| CST3 | cystatin C | -0.0683661 |
| EFNA5 | ephrin-A5 | -0.067275 |
| RPLP1 | ribosomal protein, large, P1 | -0.0657182 |
| MT2A | metallothionein 2A | -0.060976 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0599232 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0593462 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0574089 |
| TXNRD1 | thioredoxin reductase 1 | -0.055514 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0526642 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0521093 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0512798 |
| NABP1 | nucleic acid binding protein 1 | -0.050529 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0483907 |
| RPL34 | ribosomal protein L34 | -0.0482129 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0476139 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0475037 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0471292 |
| HMGA1 | high mobility group AT-hook 1 | -0.0422477 |
| B2M | beta-2-microglobulin | -0.0404948 |
| RPS6 | ribosomal protein S6 | -0.0403654 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0397618 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0390484 |
| GNAS | GNAS complex locus | -0.0381353 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0380703 |
| ACTG1 | actin gamma 1 | -0.0378754 |
| TNS3 | tensin 3 | -0.0373785 |
| RPLP0 | ribosomal protein, large, P0 | -0.036672 |
| RNF213 | ring finger protein 213 | -0.0363924 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0358099 |
| CCND1 | cyclin D1 | -0.0354021 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0352294 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0349902 |
| RPS24 | ribosomal protein S24 | -0.034597 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0330807 |
| S100A6 | S100 calcium binding protein A6 | -0.0329197 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0326253 |
| FTL | ferritin, light polypeptide | -0.0318494 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0316495 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0316155 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0309328 |
| IER3 | immediate early response 3 | -0.0306291 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0296773 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0292574 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0290197 |
| CAV2 | caveolin 2 | -0.0287123 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0287111 |
| FOXP1 | forkhead box P1 | -0.0285312 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0274632 |
| HLA-B | major histocompatibility complex, class I, B | -0.0274141 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0272976 |
| RPS25 | ribosomal protein S25 | -0.0271863 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0255911 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0254181 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0253545 |
| S100A11 | S100 calcium binding protein A11 | -0.0252545 |
| GPHN | gephyrin | -0.0251072 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0249588 |
| RIN2 | Ras and Rab interactor 2 | -0.0247061 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0246803 |
| MT1X | metallothionein 1X | -0.0242228 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0237086 |
| PRKCA | protein kinase C, alpha | -0.023474 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0234272 |
| CP | ceruloplasmin (ferroxidase) | -0.0229766 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0228106 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.022788 |
| RPS19 | ribosomal protein S19 | -0.0226674 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0224589 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0221455 |
| GM2A | GM2 ganglioside activator | -0.0220274 |
| POTEF | POTE ankyrin domain family, member F | -0.0220109 |
| PCED1B | PC-esterase domain containing 1B | -0.0219856 |
| PTMA | prothymosin, alpha | -0.0219482 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0219463 |
| TRIM56 | tripartite motif containing 56 | -0.0218554 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0216477 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0216374 |
| RPS14 | ribosomal protein S14 | -0.021321 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0212134 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.020834 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0206428 |
| CMIP | c-Maf inducing protein | -0.0204146 |
| MYOF | myoferlin | -0.0204124 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0203899 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0201328 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0198051 |
| RPS23 | ribosomal protein S23 | -0.0197942 |
| RPS16 | ribosomal protein S16 | -0.0197199 |
| IRF1 | interferon regulatory factor 1 | -0.0196433 |
| EMP1 | epithelial membrane protein 1 | -0.0196431 |
