| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Adagrasib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.102585 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.100309 |
| FAM20C | family with sequence similarity 20, member C | 0.0812704 |
| PRELID2 | PRELI domain containing 2 | 0.0740539 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0716872 |
| KYNU | kynureninase | 0.062755 |
| RAD51B | RAD51 paralog B | 0.0620333 |
| GPC6 | glypican 6 | 0.0562198 |
| VEGFA | vascular endothelial growth factor A | 0.0539058 |
| FAM13A | family with sequence similarity 13, member A | 0.0527489 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0522546 |
| PTMA | prothymosin, alpha | 0.0514958 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0512199 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0504877 |
| RUNX2 | runt-related transcription factor 2 | 0.0463584 |
| RPS12 | ribosomal protein S12 | 0.0439599 |
| MECOM | MDS1 and EVI1 complex locus | 0.0398631 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0393839 |
| DST | dystonin | 0.0387496 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0374752 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0372606 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0370138 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0369344 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0363291 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0351803 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0348714 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.034771 |
| IFI44L | interferon-induced protein 44-like | 0.0347654 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0341107 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0327058 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0324088 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0315065 |
| B2M | beta-2-microglobulin | 0.0309652 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0309315 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0302204 |
| RPL4 | ribosomal protein L4 | 0.029092 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0287739 |
| RPS3 | ribosomal protein S3 | 0.0287574 |
| ZNF804A | zinc finger protein 804A | 0.0281995 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0278387 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.0275885 |
| RPS17 | ribosomal protein S17 | 0.0270222 |
| ADD3 | adducin 3 (gamma) | 0.0269815 |
| RPL13A | ribosomal protein L13a | 0.0268429 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0257935 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0257014 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0256551 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0252105 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0251096 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.025101 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0249375 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0248167 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0245287 |
| RPL37A | ribosomal protein L37a | 0.0244657 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0239435 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0237908 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0234414 |
| ETV6 | ets variant 6 | 0.0231085 |
| LDHA | lactate dehydrogenase A | 0.0228489 |
| COL12A1 | collagen, type XII, alpha 1 | 0.0227894 |
| RPL37 | ribosomal protein L37 | 0.022769 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0226536 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0224479 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0223414 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0222341 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.022034 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0220243 |
| FBXO32 | F-box protein 32 | 0.0220231 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0216052 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0209114 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0208522 |
| RPL3 | ribosomal protein L3 | 0.0208236 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0206692 |
| CALR | calreticulin | 0.0205741 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0205273 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0204014 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0203823 |
| OGA | O-GlcNAcase | 0.0202954 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0202655 |
| HLA-A | major histocompatibility complex, class I, A | 0.0200847 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0199951 |
| PHF3 | PHD finger protein 3 | 0.0197245 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0194388 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0193786 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0193533 |
| OPTN | optineurin | 0.0192801 |
| RNF145 | ring finger protein 145 | 0.01902 |
| VMP1 | vacuole membrane protein 1 | 0.0190165 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0190121 |
| CEP250 | centrosomal protein 250kDa | 0.0186108 |
| PTGR1 | prostaglandin reductase 1 | 0.0184344 |
| ANXA1 | annexin A1 | 0.0183365 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0182907 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0180725 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0180666 |
| FANK1 | fibronectin type III and ankyrin repeat domains 1 | 0.0177685 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0177634 |
| SP100 | SP100 nuclear antigen | 0.0177433 |
| IFI44 | interferon-induced protein 44 | 0.0176693 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0172865 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.231341 |
| CD44 | CD44 molecule (Indian blood group) | -0.229331 |
| EFNA5 | ephrin-A5 | -0.158104 |
| VIM | vimentin | -0.154215 |
| CDH13 | cadherin 13 | -0.132933 |
| STC1 | stanniocalcin 1 | -0.127588 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.107707 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.101235 |
| HMGA2 | high mobility group AT-hook 2 | -0.0939093 |
| NDRG1 | N-myc downstream regulated 1 | -0.0896397 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0831771 |
| GOLGA4 | golgin A4 | -0.0816743 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0795996 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0754526 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0747209 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0715527 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0713937 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0711377 |
| MT2A | metallothionein 2A | -0.070535 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0691052 |
| CDCP1 | CUB domain containing protein 1 | -0.067277 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0664988 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0664474 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0662197 |
| SMAD3 | SMAD family member 3 | -0.065905 |
| EGR1 | early growth response 1 | -0.0658397 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0656141 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0649546 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0627357 |
| FAM107B | family with sequence similarity 107, member B | -0.0599658 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0590054 |
| NAV2 | neuron navigator 2 | -0.058738 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0563972 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0556395 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0556282 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0553053 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0540015 |
| FN1 | fibronectin 1 | -0.0522212 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0518134 |
| MTSS1 | metastasis suppressor 1 | -0.0515745 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0495388 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0494776 |
| PCBP2 | poly(rC) binding protein 2 | -0.0489189 |
| LOX | lysyl oxidase | -0.0477405 |
| EGFR | epidermal growth factor receptor | -0.0476564 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0468365 |
| MCL1 | myeloid cell leukemia 1 | -0.0468194 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.045061 |
| RAB1A | RAB1A, member RAS oncogene family | -0.044426 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0439857 |
| HMGA1 | high mobility group AT-hook 1 | -0.0434735 |
| RUNX1 | runt-related transcription factor 1 | -0.0433774 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0424803 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0423432 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0423182 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0420146 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0416969 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0416205 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.041531 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0412255 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0408677 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0406572 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0404381 |
| NRP1 | neuropilin 1 | -0.0403894 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0402339 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0400616 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.038959 |
| EMP1 | epithelial membrane protein 1 | -0.0386721 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0385622 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0383491 |
| ARF4 | ADP-ribosylation factor 4 | -0.0379687 |
| CALU | calumenin | -0.037761 |
| SEC24A | SEC24 family member A | -0.0376294 |
| ECE1 | endothelin converting enzyme 1 | -0.0374567 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0372195 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0362841 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0353221 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0352684 |
| SYNJ2 | synaptojanin 2 | -0.0345783 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0337939 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0335083 |
| MYO10 | myosin X | -0.0333037 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0330318 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0328316 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0327188 |
| PARD3 | par-3 family cell polarity regulator | -0.0321351 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0320817 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0317776 |
| FLNB | filamin B, beta | -0.031693 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0315482 |
| SPAG9 | sperm associated antigen 9 | -0.0313911 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0312968 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0306959 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.03034 |
| IER3 | immediate early response 3 | -0.0302211 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0301214 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0298931 |
| MYADM | myeloid-associated differentiation marker | -0.029816 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0297102 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0294921 |
