Adagrasib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adagrasib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adagrasib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.200612
BASP1 brain abundant, membrane attached signal protein 1 0.120333
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0724614
FGA fibrinogen alpha chain 0.0600841
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0591712
PYGL phosphorylase, glycogen, liver 0.0551721
HDAC9 histone deacetylase 9 0.0542458
CAVIN1 caveolae associated protein 1 0.0536458
LPP LIM domain containing preferred translocation partner in lipoma 0.0532534
RPL37A ribosomal protein L37a 0.0529746
TPM4 tropomyosin 4 0.0496068
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0469027
TPT1 tumor protein, translationally-controlled 1 0.0468148
IGFBP4 insulin-like growth factor binding protein 4 0.0422271
SFTPA2 surfactant protein A2 0.0402065
RPS8 ribosomal protein S8 0.0391239
PTMA prothymosin, alpha 0.0389731
KDM3A lysine (K)-specific demethylase 3A 0.0385722
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.03787
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0370891
RPL4 ribosomal protein L4 0.0367862
PLS3 plastin 3 0.0356116
NTN4 netrin 4 0.0345516
RPS12 ribosomal protein S12 0.0338018
AKAP12 A kinase (PRKA) anchor protein 12 0.0334009
IGFBP3 insulin-like growth factor binding protein 3 0.0331355
RPS17 ribosomal protein S17 0.0329069
RPS27 ribosomal protein S27 0.0325417
RPL13A ribosomal protein L13a 0.0321299
RPL37 ribosomal protein L37 0.0318447
RPS3 ribosomal protein S3 0.0315481
ZFHX3 zinc finger homeobox 3 0.0312041
KTN1 kinectin 1 (kinesin receptor) 0.0310283
SMOC1 SPARC related modular calcium binding 1 0.0309868
MRTFA myocardin related transcription factor A 0.0308813
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0308765
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0302587
RPL3 ribosomal protein L3 0.0300796
RPS29 ribosomal protein S29 0.0289422
SRRM1 serine/arginine repetitive matrix 1 0.0280008
CALR calreticulin 0.0279057
RPL31 ribosomal protein L31 0.0270967
TMSB4X thymosin beta 4, X-linked 0.0268752
KYNU kynureninase 0.0265327
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0260947
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0260003
TNS3 tensin 3 0.0259564
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0259502
LDHA lactate dehydrogenase A 0.0255696
RPS6 ribosomal protein S6 0.0255459
HLA-B major histocompatibility complex, class I, B 0.0249892
SVIL supervillin 0.0248408
STC2 stanniocalcin 2 0.0247278
CTNND1 catenin (cadherin-associated protein), delta 1 0.024656
SOX4 SRY (sex determining region Y)-box 4 0.0246143
EFNA1 ephrin-A1 0.0244991
SERF2 small EDRK-rich factor 2 0.0240168
UBAP2L ubiquitin associated protein 2-like 0.0239664
VCL vinculin 0.0238993
SETD5 SET domain containing 5 0.0236409
LMNA lamin A/C 0.0229304
ANKRD11 ankyrin repeat domain 11 0.0227561
MYOF myoferlin 0.0227513
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0223944
GPX4 glutathione peroxidase 4 0.0222605
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0220157
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0216093
RPL36 ribosomal protein L36 0.0215346
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0214685
CNRIP1 cannabinoid receptor interacting protein 1 0.0214669
DCAF5 DDB1 and CUL4 associated factor 5 0.0213344
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0210542
RPL19 ribosomal protein L19 0.0208917
SERINC1 serine incorporator 1 0.0208753
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0208445
FAM168A family with sequence similarity 168, member A 0.020836
EFNA5 ephrin-A5 0.0206269
ANXA1 annexin A1 0.0206263
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0206113
MAP4 microtubule-associated protein 4 0.0205657
MYH9 myosin, heavy chain 9, non-muscle 0.0205044
AHNAK AHNAK nucleoprotein 0.0204596
TPI1 triosephosphate isomerase 1 0.0204496
RPS13 ribosomal protein S13 0.0204437
HLA-E major histocompatibility complex, class I, E 0.0202217
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0195737
SIK3 SIK family kinase 3 0.0195116
CSDE1 cold shock domain containing E1, RNA-binding 0.0194399
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0193244
KMT2E lysine (K)-specific methyltransferase 2E 0.0192377
TFG TRK-fused gene 0.0191251
AGFG1 ArfGAP with FG repeats 1 0.0188523
SRSF4 serine/arginine-rich splicing factor 4 0.018688
ZBTB1 zinc finger and BTB domain containing 1 0.0186818
TRA2A transformer 2 alpha homolog (Drosophila) 0.0182953
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0182153
TPM1 tropomyosin 1 (alpha) 0.0181187
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0180531
EHBP1 EH domain binding protein 1 0.0179473
RPL18 ribosomal protein L18 0.0179144

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.205338
TM4SF1 transmembrane 4 L six family member 1 -0.184796
GRAMD1B GRAM domain containing 1B -0.158762
MT2A metallothionein 2A -0.157745
DOCK4 dedicator of cytokinesis 4 -0.149186
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.146291
MCL1 myeloid cell leukemia 1 -0.11713
FTH1 ferritin, heavy polypeptide 1 -0.114094
TFPI2 tissue factor pathway inhibitor 2 -0.107527
CXCL8 chemokine (C-X-C motif) ligand 8 -0.104046
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0895783
BIRC3 baculoviral IAP repeat containing 3 -0.0811671
EGR1 early growth response 1 -0.077188
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.076889
TMSB10 thymosin beta 10 -0.0703548
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0664556
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0629949
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0606572
NAV3 neuron navigator 3 -0.0591387
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0548049
P4HB prolyl 4-hydroxylase, beta polypeptide -0.050593
ASPH aspartate beta-hydroxylase -0.0499388
FAM107B family with sequence similarity 107, member B -0.0482708
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0481775
UBC ubiquitin C -0.0478723
USP34 ubiquitin specific peptidase 34 -0.045103
SLC38A1 solute carrier family 38, member 1 -0.0443156
AGO2 argonaute RISC catalytic component 2 -0.0438306
NRG1 neuregulin 1 -0.0436098
LOC112694756 uncharaterized LOC112694756 -0.0419296
RPS27A ribosomal protein S27a -0.0414458
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0410069
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0410001
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0404434
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0402631
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0401402
SFPQ splicing factor proline/glutamine-rich -0.0395008
WWOX WW domain containing oxidoreductase -0.0386938
IER3 immediate early response 3 -0.038668
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0379584
BMP6 bone morphogenetic protein 6 -0.0376092
RAB7A RAB7A, member RAS oncogene family -0.0372135
POTEF POTE ankyrin domain family, member F -0.037096
ACTN1 actinin, alpha 1 -0.0367034
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0363139
MAML3 mastermind-like 3 (Drosophila) -0.0362411
ACTG1 actin gamma 1 -0.0361264
NHSL1 NHS-like 1 -0.0361095
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0360101
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0356791
AREG amphiregulin -0.0355012
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0354337
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0351398
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0351178
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0341294
NOP58 NOP58 ribonucleoprotein -0.0340858
IGF2 insulin-like growth factor 2 -0.0340758
ENO1 enolase 1, (alpha) -0.033892
PCBP2 poly(rC) binding protein 2 -0.0332599
GLS2 glutaminase 2 (liver, mitochondrial) -0.0330808
FMNL2 formin-like 2 -0.0322748
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0312075
BIRC6 baculoviral IAP repeat containing 6 -0.0310139
FTL ferritin, light polypeptide -0.0306338
VMP1 vacuole membrane protein 1 -0.0306308
BRD2 bromodomain containing 2 -0.0304926
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0303475
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0302241
RTN4 reticulon 4 -0.0296009
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0293048
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0289583
UBASH3B ubiquitin associated and SH3 domain containing B -0.0288771
COG5 component of oligomeric golgi complex 5 -0.0287743
PFN1 profilin 1 -0.0287211
RUNX1 runt-related transcription factor 1 -0.0284567
ZFAND3 zinc finger, AN1-type domain 3 -0.0282879
ATP11A ATPase, class VI, type 11A -0.0282462
GLIS3 GLIS family zinc finger 3 -0.0282393
NABP1 nucleic acid binding protein 1 -0.0280386
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0272798
YBX1 Y box binding protein 1 -0.0271544
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0271304
MAPK8 mitogen-activated protein kinase 8 -0.0270145
ZNF207 zinc finger protein 207 -0.0269785
GNAS GNAS complex locus -0.0269212
THSD4 thrombospondin, type I, domain containing 4 -0.0268118
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.026686
ZEB1 zinc finger E-box binding homeobox 1 -0.026546
SOD2 superoxide dismutase 2, mitochondrial -0.0264887
SNX14 sorting nexin 14 -0.0264757
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0262937
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0260249
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0256895
WDR43 WD repeat domain 43 -0.0251827
TOP1 topoisomerase (DNA) I -0.0249746
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0249616
RPL23 ribosomal protein L23 -0.0245012
CMIP c-Maf inducing protein -0.0244782
NBAS neuroblastoma amplified sequence -0.0242388
MCTP1 multiple C2 domains, transmembrane 1 -0.0241253