| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Adagrasib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.179085 |
| RUNX1 | runt-related transcription factor 1 | 0.0921159 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0894204 |
| DTNA | dystrobrevin, alpha | 0.081091 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0790499 |
| KYNU | kynureninase | 0.0774317 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0744761 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0728056 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0677227 |
| CCNY | cyclin Y | 0.0674846 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0671689 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0624433 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0609869 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0604696 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0600141 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0588282 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0558574 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0542596 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0519032 |
| H1-0 | H1.0 linker histone | 0.0511908 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0507797 |
| GPHN | gephyrin | 0.0505065 |
| PHF3 | PHD finger protein 3 | 0.0503531 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0501607 |
| RPL4 | ribosomal protein L4 | 0.0501305 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0491881 |
| RPS13 | ribosomal protein S13 | 0.0489331 |
| IRS2 | insulin receptor substrate 2 | 0.0488068 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0487641 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.047307 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0455984 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0455194 |
| MMP12 | matrix metallopeptidase 12 | 0.0454048 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0451472 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0446043 |
| GPR75-ASB3 | GPR75-ASB3 readthrough | 0.044505 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0431449 |
| PHIP | pleckstrin homology domain interacting protein | 0.0430514 |
| VGLL3 | vestigial-like family member 3 | 0.0428712 |
| PTGES2 | prostaglandin E synthase 2 | 0.0428192 |
| NAV2 | neuron navigator 2 | 0.0418935 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0418499 |
| RPL27 | ribosomal protein L27 | 0.0417838 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0417714 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0416648 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0416539 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0409654 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0407962 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0407711 |
| KRT17 | keratin 17, type I | 0.0406802 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0404418 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0401583 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.0398904 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0395993 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0395742 |
| ARFIP1 | ADP-ribosylation factor interacting protein 1 | 0.0392759 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0392415 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0391785 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0388084 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0386874 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0383366 |
| EPN2 | epsin 2 | 0.0381418 |
| KRT18 | keratin 18, type I | 0.0381332 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0380672 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0376266 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0374057 |
| RPS23 | ribosomal protein S23 | 0.0370671 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0369876 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0366801 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.036451 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0363731 |
| OGA | O-GlcNAcase | 0.0363146 |
| RACK1 | receptor for activated C kinase 1 | 0.0362644 |
| MYOF | myoferlin | 0.0362591 |
| LDHA | lactate dehydrogenase A | 0.03587 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0357158 |
| SBF2 | SET binding factor 2 | 0.0353177 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0352706 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0351537 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0351441 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0350557 |
| INSIG2 | insulin induced gene 2 | 0.0349916 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0349692 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0347615 |
| KLC1 | kinesin light chain 1 | 0.0344219 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0342976 |
| WDR70 | WD repeat domain 70 | 0.0340242 |
| ATXN1 | ataxin 1 | 0.0339986 |
| SNX25 | sorting nexin 25 | 0.0338319 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0338104 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0335857 |
| PCBP2 | poly(rC) binding protein 2 | 0.0335247 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0335019 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0333878 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0333133 |
| CTBP2 | C-terminal binding protein 2 | 0.033236 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0330237 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0329985 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0328232 |
| RPL13A | ribosomal protein L13a | 0.0326868 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.126364 |
| VIM | vimentin | -0.114868 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.101036 |
| ANXA2 | annexin A2 | -0.0904253 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0805637 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0789641 |
| MYO1E | myosin IE | -0.0785878 |
| RPL35A | ribosomal protein L35a | -0.0752082 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0718668 |
| PTMA | prothymosin, alpha | -0.0698762 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0693781 |
| FN1 | fibronectin 1 | -0.0690304 |
| ATOSA | atos homolog A | -0.0686755 |
| FTL | ferritin, light polypeptide | -0.0680015 |
| OSMR | oncostatin M receptor | -0.066359 |
| NF1 | neurofibromin 1 | -0.0644176 |
| GOLGB1 | golgin B1 | -0.0636826 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0636251 |
| SRPK2 | SRSF protein kinase 2 | -0.0614071 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0613074 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0610685 |
| LAMB3 | laminin, beta 3 | -0.0608981 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0603458 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0601526 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0594757 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0592099 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0589571 |
| MCL1 | myeloid cell leukemia 1 | -0.0589211 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0588852 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0588548 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0578989 |
| POTEF | POTE ankyrin domain family, member F | -0.0574438 |
| EGR1 | early growth response 1 | -0.0564494 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0531581 |
| JMJD1C | jumonji domain containing 1C | -0.0505975 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0495115 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0494396 |
| RAB10 | RAB10, member RAS oncogene family | -0.0493397 |
| IGF2 | insulin-like growth factor 2 | -0.0491927 |
| UBAP1 | ubiquitin associated protein 1 | -0.049045 |
| USP53 | ubiquitin specific peptidase 53 | -0.0488116 |
| ZNF638 | zinc finger protein 638 | -0.0487084 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.04671 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0457777 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0457498 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0455351 |
| S100A10 | S100 calcium binding protein A10 | -0.0454271 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0452902 |
| ARF1 | ADP-ribosylation factor 1 | -0.0446911 |
| SQSTM1 | sequestosome 1 | -0.0443344 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.044176 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0437218 |
| ADNP | activity-dependent neuroprotector homeobox | -0.043694 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0429414 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0425506 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0424033 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0423908 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0423604 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0415903 |
| SDC4 | syndecan 4 | -0.0415872 |
| GPC6 | glypican 6 | -0.0415157 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0414156 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0405367 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0399651 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0399634 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0398545 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0394842 |
| RRBP1 | ribosome binding protein 1 | -0.0387254 |
| LAMC2 | laminin, gamma 2 | -0.0386977 |
| RIOK3 | RIO kinase 3 | -0.0386761 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0382867 |
| ZNF207 | zinc finger protein 207 | -0.0380922 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0380317 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0379034 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0378742 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0378468 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0377501 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0374913 |
| NRG1 | neuregulin 1 | -0.0374282 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0371494 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0370864 |
| FOXO3 | forkhead box O3 | -0.0368344 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0365398 |
| UBE3A | ubiquitin protein ligase E3A | -0.0363346 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0362857 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0359096 |
| SEPTIN2 | septin 2 | -0.0358326 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0358245 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.03522 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0349013 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0348419 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0347877 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0347833 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0345332 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0342238 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.03422 |
| SMAD2 | SMAD family member 2 | -0.034174 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0341045 |
| ZNF609 | zinc finger protein 609 | -0.0335612 |
| RPL26 | ribosomal protein L26 | -0.0335529 |
