Adagrasib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adagrasib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adagrasib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.118959
PDE10A phosphodiesterase 10A 0.099503
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0789065
RAD51B RAD51 paralog B 0.0729583
YBX3 Y box binding protein 3 0.0690814
BMP5 bone morphogenetic protein 5 0.0646411
IFI6 interferon, alpha-inducible protein 6 0.064452
DENND5B DENN/MADD domain containing 5B 0.0642902
AHNAK AHNAK nucleoprotein 0.0634061
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0610926
EEF2 eukaryotic translation elongation factor 2 0.058183
IGF1R insulin-like growth factor 1 receptor 0.054493
CSDE1 cold shock domain containing E1, RNA-binding 0.0528542
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0522256
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0520085
TXNRD1 thioredoxin reductase 1 0.0510191
KDM3A lysine (K)-specific demethylase 3A 0.0507744
PTMA prothymosin, alpha 0.0502418
RNF213 ring finger protein 213 0.0474609
PRELID2 PRELI domain containing 2 0.046996
MBNL2 muscleblind-like splicing regulator 2 0.0469493
NCOA7 nuclear receptor coactivator 7 0.0460538
BASP1 brain abundant, membrane attached signal protein 1 0.0438474
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0435033
ZBTB20 zinc finger and BTB domain containing 20 0.0427084
ANKRD36 ankyrin repeat domain 36 0.0413137
BBX bobby sox homolog (Drosophila) 0.041189
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0411764
CEP250 centrosomal protein 250kDa 0.0408027
RPS3 ribosomal protein S3 0.0398305
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0393536
DSPP dentin sialophosphoprotein 0.0392542
WWOX WW domain containing oxidoreductase 0.0389925
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0385007
HDGF hepatoma-derived growth factor 0.0377701
ANKRD36B ankyrin repeat domain 36B 0.0368664
PCLO piccolo presynaptic cytomatrix protein 0.0356668
MED13L mediator complex subunit 13-like 0.0348271
UBE2H ubiquitin-conjugating enzyme E2H 0.0341385
RPL3 ribosomal protein L3 0.0333839
PHF21A PHD finger protein 21A 0.0332498
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0331355
ADGRG6 adhesion G protein-coupled receptor G6 0.0325107
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0322437
ADAR adenosine deaminase, RNA-specific 0.0321635
SSH2 slingshot protein phosphatase 2 0.0321413
RPL37 ribosomal protein L37 0.0318767
CUL4B cullin 4B 0.0309408
GOLGB1 golgin B1 0.0304054
TNRC6B trinucleotide repeat containing 6B 0.0303844
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0302271
RNF145 ring finger protein 145 0.0300811
RPL4 ribosomal protein L4 0.029936
UBC ubiquitin C 0.0295957
XPO1 exportin 1 0.0293753
CANX calnexin 0.0289931
HLA-B major histocompatibility complex, class I, B 0.0289155
STAT1 signal transducer and activator of transcription 1, 91kDa 0.028888
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0287245
PDE4B phosphodiesterase 4B, cAMP-specific 0.0287205
DSCAM Down syndrome cell adhesion molecule 0.028601
PLS3 plastin 3 0.0283565
AEBP2 AE binding protein 2 0.0282795
RPS12 ribosomal protein S12 0.0282231
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0278842
LPP LIM domain containing preferred translocation partner in lipoma 0.0278197
KMT2A lysine (K)-specific methyltransferase 2A 0.0275119
ENO1 enolase 1, (alpha) 0.0274297
ZNF292 zinc finger protein 292 0.0273335
HELB helicase (DNA) B 0.0272743
SENP6 SUMO1/sentrin specific peptidase 6 0.0269503
SET SET nuclear proto-oncogene 0.026912
ETV6 ets variant 6 0.026815
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.026695
SFTPA2 surfactant protein A2 0.0266714
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.026559
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0262787
SNAP25 synaptosomal-associated protein, 25kDa 0.0262701
APOLD1 apolipoprotein L domain containing 1 0.0256531
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0253934
UTRN utrophin 0.0253682
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0253629
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0251951
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0249373
ZBTB1 zinc finger and BTB domain containing 1 0.0248826
LMNA lamin A/C 0.0246471
ZBTB10 zinc finger and BTB domain containing 10 0.0246363
OGA O-GlcNAcase 0.0246264
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0245025
LATS2 large tumor suppressor kinase 2 0.0244213
PTEN phosphatase and tensin homolog 0.0243543
PHF3 PHD finger protein 3 0.0242792
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0239543
MACROD2 MACRO domain containing 2 0.0238251
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0236622
MKI67 marker of proliferation Ki-67 0.0235966
MYH9 myosin, heavy chain 9, non-muscle 0.0234345
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0234151
EIF4B eukaryotic translation initiation factor 4B 0.0233893
VCL vinculin 0.0233545

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.24904
EGR1 early growth response 1 -0.183915
TFPI2 tissue factor pathway inhibitor 2 -0.176968
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.10723
MCL1 myeloid cell leukemia 1 -0.0936151
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0918238
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0850934
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0825655
RAB7A RAB7A, member RAS oncogene family -0.0780492
THSD4 thrombospondin, type I, domain containing 4 -0.0733704
POTEF POTE ankyrin domain family, member F -0.0730466
TMSB10 thymosin beta 10 -0.0693919
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0689382
TM4SF1 transmembrane 4 L six family member 1 -0.06652
EXT1 exostosin glycosyltransferase 1 -0.0652073
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0617107
NABP1 nucleic acid binding protein 1 -0.0604733
RPL35A ribosomal protein L35a -0.0589797
MYL12B myosin, light chain 12B, regulatory -0.0587693
CDK17 cyclin-dependent kinase 17 -0.0578444
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0558792
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0552163
STC1 stanniocalcin 1 -0.053862
HMGA2 high mobility group AT-hook 2 -0.0526981
MARCHF4 membrane associated ring-CH-type finger 4 -0.0521102
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0506582
DOCK5 dedicator of cytokinesis 5 -0.0492094
PFN1 profilin 1 -0.0491181
FMNL2 formin-like 2 -0.0483532
MT2A metallothionein 2A -0.0483196
ACTN1 actinin, alpha 1 -0.0463732
CDCP1 CUB domain containing protein 1 -0.0463583
ACTG1 actin gamma 1 -0.0458978
RTN4 reticulon 4 -0.0456769
NTSR1 neurotensin receptor 1 (high affinity) -0.0448644
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0443322
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0439248
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0434358
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0429705
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0422562
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0422008
AFF3 AF4/FMR2 family, member 3 -0.0413376
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0401446
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0400354
GPHN gephyrin -0.0398318
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0398164
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0396518
S100A11 S100 calcium binding protein A11 -0.0386226
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0385603
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0373401
ATP11A ATPase, class VI, type 11A -0.0368656
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0351093
ZFAND3 zinc finger, AN1-type domain 3 -0.0350909
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0342132
MCTP1 multiple C2 domains, transmembrane 1 -0.0334556
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0329798
EIF5B eukaryotic translation initiation factor 5B -0.0329599
RPLP1 ribosomal protein, large, P1 -0.0316009
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0310563
WWTR1 WW domain containing transcription regulator 1 -0.0308838
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.03058
OSMR oncostatin M receptor -0.0303859
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0302201
RPLP0 ribosomal protein, large, P0 -0.0300624
ATG7 autophagy related 7 -0.0298001
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0292104
RYR3 ryanodine receptor 3 -0.0291257
SHB Src homology 2 domain containing adaptor protein B -0.0286958
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0286154
RBM25 RNA binding motif protein 25 -0.0285133
IGF2 insulin-like growth factor 2 -0.0284625
SNX9 sorting nexin 9 -0.0283044
AGO2 argonaute RISC catalytic component 2 -0.028289
MACF1 microtubule-actin crosslinking factor 1 -0.0279848
E2F3 E2F transcription factor 3 -0.0278647
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0278357
SLC38A1 solute carrier family 38, member 1 -0.0278207
ELL2 elongation factor, RNA polymerase II, 2 -0.0273193
JMJD1C jumonji domain containing 1C -0.0269789
ICAM1 intercellular adhesion molecule 1 -0.0261145
NT5E 5'-nucleotidase, ecto (CD73) -0.0260491
SETX senataxin -0.0260283
IER3 immediate early response 3 -0.0258953
RRM2 ribonucleotide reductase M2 -0.0253726
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0253645
PXDN peroxidasin -0.025227
ANXA5 annexin A5 -0.0251682
PDLIM5 PDZ and LIM domain 5 -0.0250971
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.025047
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0249418
TUBA1C tubulin, alpha 1c -0.0246558
PFDN2 prefoldin subunit 2 -0.0245282
HMGA1 high mobility group AT-hook 1 -0.024396
RUSC2 RUN and SH3 domain containing 2 -0.0243321
KPNB1 karyopherin (importin) beta 1 -0.0242497
GRAMD1B GRAM domain containing 1B -0.0241939
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0240695
ATP13A3 ATPase type 13A3 -0.0240246
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0236726
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0234478