| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Adagrasib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.223073 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.219725 |
| VEGFA | vascular endothelial growth factor A | 0.129261 |
| TMSB4X | thymosin beta 4, X-linked | 0.127999 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.124483 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.106646 |
| AHNAK | AHNAK nucleoprotein | 0.102301 |
| UBC | ubiquitin C | 0.0992515 |
| DSPP | dentin sialophosphoprotein | 0.0976996 |
| LAMC2 | laminin, gamma 2 | 0.0831665 |
| PTMA | prothymosin, alpha | 0.0824182 |
| LDHA | lactate dehydrogenase A | 0.0809869 |
| CALR | calreticulin | 0.0772011 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0749207 |
| RPS3 | ribosomal protein S3 | 0.0729426 |
| TPM3 | tropomyosin 3 | 0.0722891 |
| KRT18 | keratin 18, type I | 0.0698153 |
| CANX | calnexin | 0.0694923 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0682896 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0681028 |
| GRB10 | growth factor receptor-bound protein 10 | 0.066147 |
| ENO1 | enolase 1, (alpha) | 0.0630588 |
| RPS12 | ribosomal protein S12 | 0.0605338 |
| RACK1 | receptor for activated C kinase 1 | 0.0601042 |
| RPL4 | ribosomal protein L4 | 0.0596633 |
| FAM13A | family with sequence similarity 13, member A | 0.0561554 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0550455 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0525069 |
| SQSTM1 | sequestosome 1 | 0.0494842 |
| HMGB2 | high mobility group box 2 | 0.0486489 |
| RPS27A | ribosomal protein S27a | 0.0481456 |
| HDGF | hepatoma-derived growth factor | 0.0478405 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0467928 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0465364 |
| LAMB3 | laminin, beta 3 | 0.0463617 |
| ARRDC3 | arrestin domain containing 3 | 0.0459165 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.044507 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0440349 |
| G0S2 | G0/G1 switch 2 | 0.0440006 |
| EPCAM | epithelial cell adhesion molecule | 0.0437913 |
| GPX4 | glutathione peroxidase 4 | 0.0435811 |
| RPL14 | ribosomal protein L14 | 0.0426478 |
| RPL3 | ribosomal protein L3 | 0.0420582 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0405443 |
| RPL13A | ribosomal protein L13a | 0.039963 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.039497 |
| RPS17 | ribosomal protein S17 | 0.0384092 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0380711 |
| SET | SET nuclear proto-oncogene | 0.0362202 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0359133 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0356061 |
| KRT8 | keratin 8, type II | 0.0355893 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0353155 |
| PLEC | plectin | 0.0352392 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0350491 |
| RAI14 | retinoic acid induced 14 | 0.0349365 |
| PLAU | plasminogen activator, urokinase | 0.0348391 |
| IRF6 | interferon regulatory factor 6 | 0.0347072 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0346773 |
| FBXO32 | F-box protein 32 | 0.0346387 |
| ANXA2 | annexin A2 | 0.0344232 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0343419 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0338428 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0326022 |
| RPL37A | ribosomal protein L37a | 0.0314887 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0301692 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0298208 |
| KRT7 | keratin 7, type II | 0.0293273 |
| RPL23 | ribosomal protein L23 | 0.0290557 |
| HLA-A | major histocompatibility complex, class I, A | 0.0284494 |
| RPL37 | ribosomal protein L37 | 0.0283679 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0278619 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0260994 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.025837 |
| PGK1 | phosphoglycerate kinase 1 | 0.0256017 |
| APP | amyloid beta (A4) precursor protein | 0.0254716 |
| RHOA | ras homolog family member A | 0.0254277 |
| MX1 | MX dynamin-like GTPase 1 | 0.0252599 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0252445 |
| CTSB | cathepsin B | 0.0252057 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0250305 |
| PKM | pyruvate kinase, muscle | 0.0249277 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.024395 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0243084 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0242118 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0241109 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.023662 |
| RPL27 | ribosomal protein L27 | 0.0235382 |
| RPS18 | ribosomal protein S18 | 0.0233321 |
| SFTPA2 | surfactant protein A2 | 0.0232956 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0230816 |
| RPL7 | ribosomal protein L7 | 0.0229434 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0226786 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.022553 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0224641 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0222235 |
| MSN | moesin | 0.0219222 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0212303 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.021153 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0210739 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.22436 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.17989 |
| RPL35A | ribosomal protein L35a | -0.132893 |
| TMSB10 | thymosin beta 10 | -0.124536 |
| FN1 | fibronectin 1 | -0.11983 |
| HMGA1 | high mobility group AT-hook 1 | -0.103491 |
| ACTG1 | actin gamma 1 | -0.0923129 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0815328 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0698571 |
| GOLGA4 | golgin A4 | -0.0672734 |
| MT2A | metallothionein 2A | -0.0630349 |
| TSC22D2 | TSC22 domain family, member 2 | -0.060419 |
| ERBIN | erbb2 interacting protein | -0.060342 |
| S100A6 | S100 calcium binding protein A6 | -0.0546332 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0524442 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0515182 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0502037 |
| FAM3C | family with sequence similarity 3, member C | -0.0484191 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0475449 |
| TXNRD1 | thioredoxin reductase 1 | -0.0467662 |
| RPL34 | ribosomal protein L34 | -0.0466796 |
| RBM25 | RNA binding motif protein 25 | -0.0461152 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0456987 |
| SLC38A1 | solute carrier family 38, member 1 | -0.042214 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0407925 |
| GNAS | GNAS complex locus | -0.0401516 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0400316 |
| EGR1 | early growth response 1 | -0.0399783 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0393995 |
| TJP1 | tight junction protein 1 | -0.0387217 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0379341 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.037287 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0371835 |
| RPLP1 | ribosomal protein, large, P1 | -0.0359195 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0357404 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0356432 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0355834 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0352089 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0350009 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0349278 |
| CCNI | cyclin I | -0.0347893 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0339922 |
| RPS19 | ribosomal protein S19 | -0.0334876 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0332685 |
| DTNA | dystrobrevin, alpha | -0.0330378 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0324532 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0321951 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0318589 |
| JMJD1C | jumonji domain containing 1C | -0.0316092 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.031565 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0314821 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0313764 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0311553 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0309456 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0307891 |
| POTEF | POTE ankyrin domain family, member F | -0.0306749 |
| CLDN4 | claudin 4 | -0.0305643 |
| TMEM165 | transmembrane protein 165 | -0.0302701 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0300624 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0298859 |
| CDCP1 | CUB domain containing protein 1 | -0.0294051 |
| CCNL1 | cyclin L1 | -0.0292795 |
| MAP4 | microtubule-associated protein 4 | -0.0292686 |
| RASAL2 | RAS protein activator like 2 | -0.0290634 |
| OCLN | occludin | -0.0282234 |
| RUNX1 | runt-related transcription factor 1 | -0.0280662 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0280604 |
| USP15 | ubiquitin specific peptidase 15 | -0.0279096 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0278863 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0274025 |
| TXNIP | thioredoxin interacting protein | -0.0273386 |
| CENPE | centromere protein E, 312kDa | -0.0268134 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0266218 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0266059 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0265348 |
| OSMR | oncostatin M receptor | -0.0264371 |
| MYO6 | myosin VI | -0.0259762 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0259109 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0254444 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0254092 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0250649 |
| NF1 | neurofibromin 1 | -0.0249033 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0248942 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0248931 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0244722 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0243435 |
| VGLL3 | vestigial-like family member 3 | -0.0243419 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0241319 |
| SPAG9 | sperm associated antigen 9 | -0.0240896 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0239853 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0239844 |
| CD2AP | CD2-associated protein | -0.0236252 |
| NUP54 | nucleoporin 54kDa | -0.0236112 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0235741 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0235463 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0233477 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.02329 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0232091 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.0230841 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0229504 |
