Adagrasib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adagrasib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Adagrasib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.153469
COL5A2 collagen, type V, alpha 2 0.128199
DST dystonin 0.118967
PM20D1 peptidase M20 domain containing 1 0.105821
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.103892
TPT1 tumor protein, translationally-controlled 1 0.10265
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.101554
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0992785
KYNU kynureninase 0.0977591
RPS12 ribosomal protein S12 0.0958701
ASPH aspartate beta-hydroxylase 0.0903879
PDLIM5 PDZ and LIM domain 5 0.0881059
PCBP3 poly(rC) binding protein 3 0.0774896
RPL4 ribosomal protein L4 0.0766545
RPS3 ribosomal protein S3 0.0727345
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0710957
RAB3B RAB3B, member RAS oncogene family 0.0684992
LDHA lactate dehydrogenase A 0.0675215
GDA guanine deaminase 0.0665395
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0644933
HSPA8 heat shock 70kDa protein 8 0.0643214
UBC ubiquitin C 0.0630493
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0622477
MCL1 myeloid cell leukemia 1 0.0617943
BZW1 basic leucine zipper and W2 domains 1 0.0604284
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0599217
ENO1 enolase 1, (alpha) 0.0591533
COL8A1 collagen, type VIII, alpha 1 0.0582384
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0576753
CANX calnexin 0.0558508
RPL37A ribosomal protein L37a 0.0515308
PGK1 phosphoglycerate kinase 1 0.0511071
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.050101
EEF2 eukaryotic translation elongation factor 2 0.0495721
RPL3 ribosomal protein L3 0.0492974
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0487972
STC1 stanniocalcin 1 0.0479197
PSD3 pleckstrin and Sec7 domain containing 3 0.0462844
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0460879
SAMD4A sterile alpha motif domain containing 4A 0.0448775
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0425973
SH3KBP1 SH3-domain kinase binding protein 1 0.0423774
RPS27A ribosomal protein S27a 0.0405805
INHBA inhibin, beta A 0.0399381
RPL13A ribosomal protein L13a 0.0398599
AHNAK AHNAK nucleoprotein 0.0389316
RPL26 ribosomal protein L26 0.0383088
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0377942
TNIP1 TNFAIP3 interacting protein 1 0.0372688
RPL7A ribosomal protein L7a 0.0372491
CALR calreticulin 0.0370801
ZEB2 zinc finger E-box binding homeobox 2 0.0360592
RPL27 ribosomal protein L27 0.0359945
RACK1 receptor for activated C kinase 1 0.0359787
BCAR3 breast cancer anti-estrogen resistance 3 0.0354538
MYH9 myosin, heavy chain 9, non-muscle 0.0333237
CTSC cathepsin C 0.0327415
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0326302
NRCAM neuronal cell adhesion molecule 0.0323544
COL4A6 collagen, type IV, alpha 6 0.0319229
TBXT T-box transcription factor T 0.0316514
TMSB4X thymosin beta 4, X-linked 0.0316466
TPM3 tropomyosin 3 0.0315361
RPL37 ribosomal protein L37 0.0307703
BLTP2 bridge-like lipid transfer protein family member 2 0.0307476
SET SET nuclear proto-oncogene 0.029894
CTSL cathepsin L 0.0294795
ALPK2 alpha-kinase 2 0.0291408
ITPRID2 ITPR interacting domain containing 2 0.0289997
CUL4B cullin 4B 0.0288037
RPL14 ribosomal protein L14 0.0286342
CHL1 cell adhesion molecule L1-like 0.0282309
RPH3AL rabphilin 3A-like (without C2 domains) 0.0280009
NFE2L1 nuclear factor, erythroid 2-like 1 0.0277865
FNDC3B fibronectin type III domain containing 3B 0.0275123
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.027427
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0274215
DOCK4 dedicator of cytokinesis 4 0.0269736
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0268203
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0257476
AGFG1 ArfGAP with FG repeats 1 0.0255275
SRRM2 serine/arginine repetitive matrix 2 0.0250765
BDNF brain-derived neurotrophic factor 0.0249719
RPS8 ribosomal protein S8 0.0249658
RIGI RNA sensor RIG-I 0.0244395
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0243612
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0241112
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0240326
RPS17 ribosomal protein S17 0.023731
TENM2 teneurin transmembrane protein 2 0.0233679
EIF4H eukaryotic translation initiation factor 4H 0.0223493
RPL31 ribosomal protein L31 0.0222599
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0220843
ENO2 enolase 2 (gamma, neuronal) 0.0220446
BMP6 bone morphogenetic protein 6 0.021912
CCDC68 coiled-coil domain containing 68 0.0217966
RPS18 ribosomal protein S18 0.0215815
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0211659
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0209107
GPRIN3 GPRIN family member 3 0.0208297

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.126194
TMSB10 thymosin beta 10 -0.119076
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112272
RPL35A ribosomal protein L35a -0.110608
SMYD3 SET and MYND domain containing 3 -0.0997011
FTL ferritin, light polypeptide -0.0761685
NALF1 NALCN channel auxiliary factor 1 -0.0727991
TXNRD1 thioredoxin reductase 1 -0.0661945
VIM vimentin -0.0636774
FTH1 ferritin, heavy polypeptide 1 -0.0630185
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.062529
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0621656
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0621218
GNAS GNAS complex locus -0.0579681
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0575125
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0560316
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0559053
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0555247
RPS6 ribosomal protein S6 -0.0554025
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.05525
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.054628
RTN4 reticulon 4 -0.0540998
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0529638
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0485478
RPS21 ribosomal protein S21 -0.0480548
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0471773
PFN1 profilin 1 -0.0461201
RPLP1 ribosomal protein, large, P1 -0.0461154
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0447382
PDIA3 protein disulfide isomerase family A, member 3 -0.0424121
RAB7A RAB7A, member RAS oncogene family -0.0416886
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0403715
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0402682
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0401375
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0399624
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.039596
CADM2 cell adhesion molecule 2 -0.0391904
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0391387
NCKAP5 NCK-associated protein 5 -0.0386827
S100A6 S100 calcium binding protein A6 -0.0381384
VDAC1 voltage-dependent anion channel 1 -0.0373925
NDRG1 N-myc downstream regulated 1 -0.0372469
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0367467
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0362684
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0360886
RPLP0 ribosomal protein, large, P0 -0.0352902
CUX1 cut-like homeobox 1 -0.0350699
RPS19 ribosomal protein S19 -0.0331934
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0331123
TTC28 tetratricopeptide repeat domain 28 -0.0330504
LAMA5 laminin, alpha 5 -0.0330366
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0330211
PDE4D phosphodiesterase 4D, cAMP-specific -0.032849
KPNB1 karyopherin (importin) beta 1 -0.0325806
JMJD1C jumonji domain containing 1C -0.0325099
TFPI2 tissue factor pathway inhibitor 2 -0.0324298
BIRC6 baculoviral IAP repeat containing 6 -0.0314996
EIF5B eukaryotic translation initiation factor 5B -0.0313421
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0312281
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0311797
PTPRM protein tyrosine phosphatase, receptor type, M -0.0310199
RPS28 ribosomal protein S28 -0.0309069
ATP5F1B ATP synthase F1 subunit beta -0.0308514
PTK2 protein tyrosine kinase 2 -0.0306736
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0303155
SRPK2 SRSF protein kinase 2 -0.0301865
ZNF207 zinc finger protein 207 -0.0296161
ADNP activity-dependent neuroprotector homeobox -0.02948
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0294003
MAP1B microtubule-associated protein 1B -0.0291147
NPEPPS aminopeptidase puromycin sensitive -0.028958
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0287921
USP3 ubiquitin specific peptidase 3 -0.0286757
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0286528
POTEF POTE ankyrin domain family, member F -0.0286415
ANTXR1 anthrax toxin receptor 1 -0.0285369
PALLD palladin, cytoskeletal associated protein -0.0284657
ADGRD1 adhesion G protein-coupled receptor D1 -0.0281412
BZW2 basic leucine zipper and W2 domains 2 -0.0278175
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0273626
SEPTIN7 septin 7 -0.0270514
MCTP1 multiple C2 domains, transmembrane 1 -0.0265486
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0265315
CBX3 chromobox homolog 3 -0.0264365
BCAS3 breast carcinoma amplified sequence 3 -0.0262839
RANBP17 RAN binding protein 17 -0.0262179
ATP5F1E ATP synthase F1 subunit epsilon -0.0261396
AUTS2 autism susceptibility candidate 2 -0.0260381
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0257003
BSG basigin (Ok blood group) -0.0250299
PCBP2 poly(rC) binding protein 2 -0.0248649
EGR1 early growth response 1 -0.0248472
NOP58 NOP58 ribonucleoprotein -0.0248359
RPS14 ribosomal protein S14 -0.0247004
MORF4L2 mortality factor 4 like 2 -0.0245675
PRKN parkin RBR E3 ubiquitin protein ligase -0.0242192
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0241063
UGCG UDP-glucose ceramide glucosyltransferase -0.0238825
TSC22D2 TSC22 domain family, member 2 -0.023844
NUP58 nucleoporin 58 -0.0237457