Adagrasib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adagrasib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adagrasib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.170513
EGFR epidermal growth factor receptor 0.154651
ENO1 enolase 1, (alpha) 0.119182
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.110138
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0881447
RBM39 RNA binding motif protein 39 0.085252
PICALM phosphatidylinositol binding clathrin assembly protein 0.0847998
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0830074
VEGFA vascular endothelial growth factor A 0.0802858
RPL37 ribosomal protein L37 0.0788804
ZNF638 zinc finger protein 638 0.0777178
MYH9 myosin, heavy chain 9, non-muscle 0.0761602
AKAP9 A kinase (PRKA) anchor protein 9 0.0748606
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0724721
ARRDC3 arrestin domain containing 3 0.0719829
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0719649
SBF2 SET binding factor 2 0.0708338
PRRC2C proline-rich coiled-coil 2C 0.0703969
BCLAF1 BCL2-associated transcription factor 1 0.0702312
RAB1A RAB1A, member RAS oncogene family 0.0689373
BACE2 beta-site APP-cleaving enzyme 2 0.0677207
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0672704
SMAD3 SMAD family member 3 0.0664504
USP47 ubiquitin specific peptidase 47 0.0656944
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0648898
LARP4B La ribonucleoprotein domain family, member 4B 0.0646884
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.064142
BBX bobby sox homolog (Drosophila) 0.0626801
RPS12 ribosomal protein S12 0.0621271
PRELID2 PRELI domain containing 2 0.0615403
RPS25 ribosomal protein S25 0.0614973
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0610711
RPS3 ribosomal protein S3 0.0608262
FAM13A family with sequence similarity 13, member A 0.0602728
TXNRD1 thioredoxin reductase 1 0.0599633
MYOF myoferlin 0.0599083
LRP12 low density lipoprotein receptor-related protein 12 0.0598665
RPL19 ribosomal protein L19 0.0587931
N4BP2L2 NEDD4 binding protein 2-like 2 0.0587264
MBNL2 muscleblind-like splicing regulator 2 0.0583833
CD109 CD109 molecule 0.0580902
CSNK1A1 casein kinase 1, alpha 1 0.0580412
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0573939
KTN1 kinectin 1 (kinesin receptor) 0.0570661
GLG1 golgi glycoprotein 1 0.0567234
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0565691
RPS19 ribosomal protein S19 0.0558562
HELZ helicase with zinc finger 0.0555796
RUNX1 runt-related transcription factor 1 0.0549204
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0545609
DSCAM Down syndrome cell adhesion molecule 0.0544467
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0536038
GOSR1 golgi SNAP receptor complex member 1 0.0535972
CHMP4B charged multivesicular body protein 4B 0.0533474
OGA O-GlcNAcase 0.0533448
RPL8 ribosomal protein L8 0.0532744
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0532527
RPL9 ribosomal protein L9 0.0531528
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0530469
USP34 ubiquitin specific peptidase 34 0.0517744
MTDH metadherin 0.0503432
LGALS3 lectin, galactoside-binding, soluble, 3 0.0500159
PRKG1 protein kinase, cGMP-dependent, type I 0.0492349
PCBP3 poly(rC) binding protein 3 0.0492224
ZCCHC7 zinc finger, CCHC domain containing 7 0.0474655
TMEM41B transmembrane protein 41B 0.0466422
GOLGB1 golgin B1 0.045711
ZNF608 zinc finger protein 608 0.0454889
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0453645
TM4SF1 transmembrane 4 L six family member 1 0.0453297
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.044927
AHNAK AHNAK nucleoprotein 0.0440956
TOP1 topoisomerase (DNA) I 0.0433613
TPM4 tropomyosin 4 0.0431602
FMN1 formin 1 0.0417176
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0416377
SAMD4A sterile alpha motif domain containing 4A 0.0415553
NDRG1 N-myc downstream regulated 1 0.0414713
COL5A2 collagen, type V, alpha 2 0.0414436
TAS2R14 taste receptor, type 2, member 14 0.0413989
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.041366
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0413246
GSK3B glycogen synthase kinase 3 beta 0.0413231
INHBA inhibin, beta A 0.0406881
USP9X ubiquitin specific peptidase 9, X-linked 0.0399468
STAG2 stromal antigen 2 0.0395855
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0389968
MYO5B myosin VB 0.0388373
LOC102724023 ES1 protein homolog, mitochondrial 0.0381472
CHEK2 checkpoint kinase 2 0.0376795
CCNI cyclin I 0.0373231
RACK1 receptor for activated C kinase 1 0.0366077
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0365731
MED13L mediator complex subunit 13-like 0.0355218
MON2 MON2 homolog (S. cerevisiae) 0.0354951
RPL28 ribosomal protein L28 0.0351501
POTEF POTE ankyrin domain family, member F 0.0350616
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0349125
RAB7A RAB7A, member RAS oncogene family 0.0348933
ZNF609 zinc finger protein 609 0.0348472

decreased expression

Symbol Name Standardized Value
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.119743
IGF2 insulin-like growth factor 2 -0.117412
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.112349
MAML2 mastermind-like 2 (Drosophila) -0.109903
GPC6 glypican 6 -0.100934
MACF1 microtubule-actin crosslinking factor 1 -0.0992947
PTMA prothymosin, alpha -0.0979356
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0963087
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0950541
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0937601
RBM25 RNA binding motif protein 25 -0.0932227
IGFBP3 insulin-like growth factor binding protein 3 -0.0919688
NAP1L1 nucleosome assembly protein 1-like 1 -0.0903186
VCL vinculin -0.0863679
SNX9 sorting nexin 9 -0.0809061
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0793715
MAP4 microtubule-associated protein 4 -0.0786255
PRKCA protein kinase C, alpha -0.0778312
SP100 SP100 nuclear antigen -0.0752998
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0734071
FN1 fibronectin 1 -0.072158
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0715428
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0690037
LRP1B low density lipoprotein receptor-related protein 1B -0.0689352
ELOVL5 ELOVL fatty acid elongase 5 -0.0676674
EGR1 early growth response 1 -0.0654849
MCL1 myeloid cell leukemia 1 -0.0647652
RPS6 ribosomal protein S6 -0.0643115
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0641652
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0631182
PDLIM5 PDZ and LIM domain 5 -0.0616473
RPL26 ribosomal protein L26 -0.0613574
NKD1 naked cuticle homolog 1 (Drosophila) -0.0609819
ANKRD28 ankyrin repeat domain 28 -0.0601445
MAML3 mastermind-like 3 (Drosophila) -0.0597064
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.059375
DOCK5 dedicator of cytokinesis 5 -0.0591821
RIGI RNA sensor RIG-I -0.058209
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0580939
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0576278
JMJD1C jumonji domain containing 1C -0.0576134
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0573801
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0554337
CANX calnexin -0.0550347
VIM vimentin -0.0546583
LAMA4 laminin, alpha 4 -0.0532433
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0523701
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0522041
ZMYND8 zinc finger, MYND-type containing 8 -0.0516746
SCFD1 sec1 family domain containing 1 -0.0512181
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.050826
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.050603
PSD3 pleckstrin and Sec7 domain containing 3 -0.0503901
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0497913
ANO6 anoctamin 6 -0.0492963
DIAPH2 diaphanous-related formin 2 -0.0487357
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0484121
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0481983
LAMB3 laminin, beta 3 -0.0481714
RTN4 reticulon 4 -0.0480656
HMGA2 high mobility group AT-hook 2 -0.0479122
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0477996
EXT1 exostosin glycosyltransferase 1 -0.0477811
FHIT fragile histidine triad -0.0474891
PRKD3 protein kinase D3 -0.0472363
MBD5 methyl-CpG binding domain protein 5 -0.0470913
DLG1 discs, large homolog 1 (Drosophila) -0.0469003
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0467123
RPL35A ribosomal protein L35a -0.046544
NUP58 nucleoporin 58 -0.045964
PDIA3 protein disulfide isomerase family A, member 3 -0.0442041
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.043044
GOLGA4 golgin A4 -0.0428155
VMP1 vacuole membrane protein 1 -0.0415617
CEMIP cell migration inducing protein, hyaluronan binding -0.0413975
NAV2 neuron navigator 2 -0.0410845
NAMPT nicotinamide phosphoribosyltransferase -0.0406874
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0401229
ARHGAP32 Rho GTPase activating protein 32 -0.0396762
FOXP1 forkhead box P1 -0.0396083
ANTXR2 anthrax toxin receptor 2 -0.0391677
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0390041
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.038874
PIBF1 progesterone immunomodulatory binding factor 1 -0.0388076
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0385035
GNAS GNAS complex locus -0.0383019
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0381638
PUM2 pumilio RNA-binding family member 2 -0.037805
RPL31 ribosomal protein L31 -0.0376171
EEF2 eukaryotic translation elongation factor 2 -0.0375372
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.037086
ACTN4 actinin, alpha 4 -0.0368374
KAT6B K(lysine) acetyltransferase 6B -0.0367589
SPIDR scaffolding protein involved in DNA repair -0.0362007
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0360279
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0359538
FTH1 ferritin, heavy polypeptide 1 -0.0358778
CDH13 cadherin 13 -0.0355045
BPTF bromodomain PHD finger transcription factor -0.0351133
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.035004