| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Adagrasib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL5A2 | collagen, type V, alpha 2 | 0.111819 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.111733 |
| COL3A1 | collagen, type III, alpha 1 | 0.10388 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0974736 |
| ITGAV | integrin, alpha V | 0.0915881 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0861752 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0718167 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0699565 |
| TMSB4X | thymosin beta 4, X-linked | 0.0689174 |
| RPL4 | ribosomal protein L4 | 0.0681664 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.065912 |
| NCKAP1 | NCK-associated protein 1 | 0.0653425 |
| HDAC9 | histone deacetylase 9 | 0.0607372 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0605173 |
| H1-4 | H1.4 linker histone, cluster member | 0.0538158 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0531768 |
| RPS12 | ribosomal protein S12 | 0.0510298 |
| ZNF608 | zinc finger protein 608 | 0.0508991 |
| RPL3 | ribosomal protein L3 | 0.0497908 |
| RPS2 | ribosomal protein S2 | 0.0496015 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0491841 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0490994 |
| PDGFC | platelet derived growth factor C | 0.0484458 |
| RPL37 | ribosomal protein L37 | 0.046673 |
| DST | dystonin | 0.0466054 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0461709 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0453673 |
| UPP1 | uridine phosphorylase 1 | 0.0440265 |
| CFL2 | cofilin 2 (muscle) | 0.0440156 |
| ENAH | enabled homolog (Drosophila) | 0.0430695 |
| THBS1 | thrombospondin 1 | 0.0429859 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0424554 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0420661 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0417824 |
| RFPL4B | ret finger protein-like 4B | 0.0416313 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0413916 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0413655 |
| TLK1 | tousled-like kinase 1 | 0.0408641 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0406335 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0402628 |
| CADM2 | cell adhesion molecule 2 | 0.0399794 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0396475 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0393061 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0385595 |
| MB21D2 | Mab-21 domain containing 2 | 0.0384549 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0384234 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.038386 |
| RPL26 | ribosomal protein L26 | 0.0374316 |
| ANXA1 | annexin A1 | 0.0371791 |
| MKI67 | marker of proliferation Ki-67 | 0.0368194 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0364429 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0364421 |
| RPS18 | ribosomal protein S18 | 0.0362125 |
| PCDH18 | protocadherin 18 | 0.0357976 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0357235 |
| FOXG1 | forkhead box G1 | 0.0356766 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0355442 |
| STMN1 | stathmin 1 | 0.0353146 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0349248 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0346112 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0340322 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0339051 |
| GASK1B | golgi associated kinase 1B | 0.0335233 |
| H1-5 | H1.5 linker histone, cluster member | 0.0334206 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0333933 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0332411 |
| RPL7 | ribosomal protein L7 | 0.0328145 |
| ARHGAP15 | Rho GTPase activating protein 15 | 0.032254 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0322329 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.0319772 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0318829 |
| RPL13A | ribosomal protein L13a | 0.0317985 |
| FST | follistatin | 0.0317123 |
| PTMA | prothymosin, alpha | 0.0313584 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0305067 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0302335 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0300334 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0297157 |
| SP3 | Sp3 transcription factor | 0.029669 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0296253 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0291635 |
| FUS | FUS RNA binding protein | 0.0290449 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | 0.0290074 |
| RDX | radixin | 0.0286808 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0285775 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0283957 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0283681 |
| SFRP4 | secreted frizzled-related protein 4 | 0.0282379 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0277893 |
| SFTPA2 | surfactant protein A2 | 0.0277583 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0276319 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0275463 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0275426 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0273533 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.027164 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0267247 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0264341 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0263119 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0259267 |
| KIF5B | kinesin family member 5B | 0.0258904 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.148086 |
| TSC22D2 | TSC22 domain family, member 2 | -0.117559 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.108654 |
| TMSB10 | thymosin beta 10 | -0.107456 |
| VIM | vimentin | -0.0912214 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0837132 |
| SRP54 | signal recognition particle 54kDa | -0.0686433 |
| GNAS | GNAS complex locus | -0.0666072 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0629219 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0624119 |
| RTN4 | reticulon 4 | -0.0612626 |
| HMGB1 | high mobility group box 1 | -0.0582026 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0569107 |
| ACTN4 | actinin, alpha 4 | -0.0553365 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.055081 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0513297 |
| RPLP1 | ribosomal protein, large, P1 | -0.0512513 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0507177 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0505255 |
| RPL35A | ribosomal protein L35a | -0.0503981 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0503743 |
| NEBL | nebulette | -0.048441 |
| YBX1 | Y box binding protein 1 | -0.048187 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0479673 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0467835 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0466021 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0455735 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0441608 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0440677 |
| PFN1 | profilin 1 | -0.0439865 |
| POTEF | POTE ankyrin domain family, member F | -0.0438223 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0428215 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0424567 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0418407 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.04165 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0412223 |
| PCDH9 | protocadherin 9 | -0.0404228 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0401434 |
| NF1 | neurofibromin 1 | -0.0400808 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0400405 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0400084 |
| ANK2 | ankyrin 2, neuronal | -0.0393005 |
| CUX1 | cut-like homeobox 1 | -0.0386507 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0381889 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0377652 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0375667 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0373426 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0370174 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0361574 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.036094 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0357252 |
| SMYD3 | SET and MYND domain containing 3 | -0.0355364 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0353121 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0352517 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0351691 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0350734 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0350512 |
| ATXN1 | ataxin 1 | -0.0348144 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0346308 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0343942 |
| NRG1 | neuregulin 1 | -0.0340569 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0339373 |
| FLNB | filamin B, beta | -0.0338018 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0337032 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0336778 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0332331 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0332032 |
| SLC44A5 | solute carrier family 44, member 5 | -0.0329175 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0328495 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0327353 |
| COL1A2 | collagen, type I, alpha 2 | -0.032673 |
| SETD5 | SET domain containing 5 | -0.0326687 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0325529 |
| SYT1 | synaptotagmin I | -0.0324447 |
| RTN3 | reticulon 3 | -0.032386 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0321751 |
| URI1 | URI1, prefoldin-like chaperone | -0.0320471 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0319639 |
| SGO2 | shugoshin 2 | -0.0319064 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0318278 |
| LMNA | lamin A/C | -0.0316457 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0316452 |
| NOP58 | NOP58 ribonucleoprotein | -0.031586 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0314735 |
| TMEM165 | transmembrane protein 165 | -0.0313449 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0313176 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | -0.0312806 |
| BRMS1L | breast cancer metastasis-suppressor 1-like | -0.031164 |
| MYO10 | myosin X | -0.0310791 |
| TRAK1 | trafficking protein, kinesin binding 1 | -0.0308818 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0308132 |
| FRY | furry homolog (Drosophila) | -0.0308073 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0303407 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0303276 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0302472 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0299843 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0299358 |
| TUT4 | terminal uridylyl transferase 4 | -0.0298696 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0298225 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0297595 |
