| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.14047 |
| TMSB4X | thymosin beta 4, X-linked | 0.139914 |
| AHNAK | AHNAK nucleoprotein | 0.115291 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.114773 |
| PTMA | prothymosin, alpha | 0.113905 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.10538 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0908201 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0866864 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0729766 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0675195 |
| RPL4 | ribosomal protein L4 | 0.0674962 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0627797 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0618518 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0587125 |
| RPL3 | ribosomal protein L3 | 0.0548711 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0528523 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0526951 |
| EVI5 | ecotropic viral integration site 5 | 0.0526342 |
| SET | SET nuclear proto-oncogene | 0.051072 |
| RPS3 | ribosomal protein S3 | 0.050815 |
| MKI67 | marker of proliferation Ki-67 | 0.0501834 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0494716 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.049222 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0477538 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0451193 |
| HDGF | hepatoma-derived growth factor | 0.0428379 |
| TXNIP | thioredoxin interacting protein | 0.042006 |
| RPL26 | ribosomal protein L26 | 0.0419781 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0417567 |
| UBC | ubiquitin C | 0.041722 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0413807 |
| ANXA1 | annexin A1 | 0.0411846 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.041112 |
| PGK1 | phosphoglycerate kinase 1 | 0.0392193 |
| RPL37A | ribosomal protein L37a | 0.0390521 |
| RPS12 | ribosomal protein S12 | 0.0389984 |
| EZR | ezrin | 0.0387798 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0380639 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0377811 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0375177 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0374357 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0369093 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0364025 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0356377 |
| CANX | calnexin | 0.0352476 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0350787 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0347755 |
| NCKAP1 | NCK-associated protein 1 | 0.0345375 |
| FAT1 | FAT atypical cadherin 1 | 0.0337899 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0336403 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0335032 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0330665 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.032831 |
| OGA | O-GlcNAcase | 0.0326761 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0326609 |
| CALR | calreticulin | 0.0323868 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0323004 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0322345 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0321527 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0321011 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0316286 |
| QKI | QKI, KH domain containing, RNA binding | 0.0315509 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0313187 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0312805 |
| RPL7A | ribosomal protein L7a | 0.0308937 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0307536 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0302002 |
| RPS27A | ribosomal protein S27a | 0.0298471 |
| RPL14 | ribosomal protein L14 | 0.0293895 |
| CASC3 | cancer susceptibility candidate 3 | 0.0291425 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0287728 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0285254 |
| ECT2 | epithelial cell transforming 2 | 0.0282424 |
| CDC73 | cell division cycle 73 | 0.0281366 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0276684 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0274732 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0273987 |
| DIAPH3 | diaphanous-related formin 3 | 0.0267765 |
| TPM3 | tropomyosin 3 | 0.026672 |
| RBM39 | RNA binding motif protein 39 | 0.0265495 |
| RRBP1 | ribosome binding protein 1 | 0.0264241 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0264011 |
| CEP250 | centrosomal protein 250kDa | 0.0263073 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0263018 |
| HELZ | helicase with zinc finger | 0.0262961 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 0.0261892 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0260762 |
| NAV2 | neuron navigator 2 | 0.0260276 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0254824 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0253075 |
| ANKRD36 | ankyrin repeat domain 36 | 0.024972 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0249532 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0247068 |
| LDHA | lactate dehydrogenase A | 0.0245654 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0245099 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.024458 |
| CENPF | centromere protein F, 350/400kDa | 0.024375 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0241164 |
| TMF1 | TATA element modulatory factor 1 | 0.0240791 |
| YEATS2 | YEATS domain containing 2 | 0.0240439 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.17458 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.129587 |
| RPL35A | ribosomal protein L35a | -0.120308 |
| EGFR | epidermal growth factor receptor | -0.095352 |
| TXNRD1 | thioredoxin reductase 1 | -0.0907436 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0894334 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0846947 |
| ACTG1 | actin gamma 1 | -0.0795346 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0783859 |
| POTEF | POTE ankyrin domain family, member F | -0.0713311 |
| RPS6 | ribosomal protein S6 | -0.0711702 |
| PKM | pyruvate kinase, muscle | -0.0706184 |
| CCND1 | cyclin D1 | -0.0663458 |
| S100A6 | S100 calcium binding protein A6 | -0.0646412 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0588417 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0586592 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0572335 |
| RTN4 | reticulon 4 | -0.0520943 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0520086 |
| PFN1 | profilin 1 | -0.0495239 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0471863 |
| RPS19 | ribosomal protein S19 | -0.0457596 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.045689 |
| RPLP0 | ribosomal protein, large, P0 | -0.0434265 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0430684 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.042448 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0407413 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0401338 |
| LOC112694756 | uncharaterized LOC112694756 | -0.040095 |
| DUSP4 | dual specificity phosphatase 4 | -0.0398238 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0375162 |
| HMGA1 | high mobility group AT-hook 1 | -0.0371444 |
| RPL34 | ribosomal protein L34 | -0.0370281 |
| JMJD1C | jumonji domain containing 1C | -0.0370253 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0362486 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0361493 |
| FOXP1 | forkhead box P1 | -0.0361038 |
| PRDX2 | peroxiredoxin 2 | -0.036103 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0360941 |
| SMYD3 | SET and MYND domain containing 3 | -0.0357094 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0346294 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.0345712 |
| RPLP1 | ribosomal protein, large, P1 | -0.034397 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0342898 |
| TMSB10 | thymosin beta 10 | -0.0323771 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0321295 |
| S100A4 | S100 calcium binding protein A4 | -0.0319234 |
| GSE1 | Gse1 coiled-coil protein | -0.0318101 |
| GPHN | gephyrin | -0.0313016 |
| ATP9B | ATPase, class II, type 9B | -0.030771 |
| OSMR | oncostatin M receptor | -0.0307646 |
| METTL15 | methyltransferase like 15 | -0.0302041 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0301495 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0301056 |
| DGKH | diacylglycerol kinase, eta | -0.0298697 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0297987 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0293695 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0288445 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0282552 |
| PYGB | phosphorylase, glycogen; brain | -0.028065 |
| S100A11 | S100 calcium binding protein A11 | -0.0280335 |
| ZNF438 | zinc finger protein 438 | -0.028013 |
| GLI3 | GLI family zinc finger 3 | -0.0275946 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0271648 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0271447 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0270878 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0269433 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0267415 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0266796 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0255796 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0255215 |
| EXOC6B | exocyst complex component 6B | -0.025475 |
| B2M | beta-2-microglobulin | -0.0251943 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0248479 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0245435 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0244996 |
| NBEA | neurobeachin | -0.0244964 |
| ARHGAP25 | Rho GTPase activating protein 25 | -0.0244652 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0242196 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0238458 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0236083 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0236075 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0233852 |
| RPS23 | ribosomal protein S23 | -0.0232019 |
| NBEAL1 | neurobeachin-like 1 | -0.0230495 |
| PHF14 | PHD finger protein 14 | -0.0228317 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0227744 |
| S100A9 | S100 calcium binding protein A9 | -0.0221776 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0221633 |
| FLNB | filamin B, beta | -0.0221431 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0221314 |
| RPS20 | ribosomal protein S20 | -0.0221229 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0218965 |
| COMMD10 | COMM domain containing 10 | -0.0217974 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.021695 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0215975 |
| RPS5 | ribosomal protein S5 | -0.021441 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.0211702 |
| RPL27A | ribosomal protein L27a | -0.0211298 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0210883 |
