| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.280593 |
| VEGFA | vascular endothelial growth factor A | 0.223945 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.21438 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.14173 |
| LDHA | lactate dehydrogenase A | 0.102223 |
| COL6A3 | collagen, type VI, alpha 3 | 0.101794 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.101295 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0979317 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0937956 |
| RPS12 | ribosomal protein S12 | 0.0922423 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0891731 |
| TMSB4X | thymosin beta 4, X-linked | 0.0839016 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0807714 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0795335 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.077641 |
| NAV2 | neuron navigator 2 | 0.0715391 |
| AHNAK | AHNAK nucleoprotein | 0.0712664 |
| UBC | ubiquitin C | 0.0704633 |
| RPS3 | ribosomal protein S3 | 0.0703101 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0701582 |
| SFTPA2 | surfactant protein A2 | 0.0683497 |
| MSN | moesin | 0.0617629 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0591403 |
| CALR | calreticulin | 0.058241 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0572246 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0570757 |
| RPL37A | ribosomal protein L37a | 0.0548888 |
| ADM | adrenomedullin | 0.0540312 |
| APP | amyloid beta (A4) precursor protein | 0.0535252 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0526206 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0519795 |
| DST | dystonin | 0.0515352 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0513745 |
| HDAC9 | histone deacetylase 9 | 0.0513681 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0510534 |
| STC2 | stanniocalcin 2 | 0.0484772 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.048413 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0471031 |
| CANX | calnexin | 0.0469307 |
| RPS17 | ribosomal protein S17 | 0.0468429 |
| OPTN | optineurin | 0.0467854 |
| CEP250 | centrosomal protein 250kDa | 0.0462434 |
| RPS27A | ribosomal protein S27a | 0.0443082 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0436038 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0428438 |
| OGA | O-GlcNAcase | 0.0428391 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0423938 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0421409 |
| TPM3 | tropomyosin 3 | 0.0404313 |
| RPL4 | ribosomal protein L4 | 0.0397978 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0397171 |
| RPS18 | ribosomal protein S18 | 0.0371208 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0365626 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0362563 |
| RPL3 | ribosomal protein L3 | 0.0359676 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0359564 |
| RPL13A | ribosomal protein L13a | 0.0340362 |
| SET | SET nuclear proto-oncogene | 0.0338311 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0337502 |
| HLA-A | major histocompatibility complex, class I, A | 0.0334448 |
| RPS8 | ribosomal protein S8 | 0.0325169 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0318153 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0315646 |
| SERINC1 | serine incorporator 1 | 0.0315489 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0311658 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0308461 |
| CUL4B | cullin 4B | 0.0306896 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0306262 |
| ASPH | aspartate beta-hydroxylase | 0.0304008 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.030389 |
| FMNL2 | formin-like 2 | 0.0303625 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.03034 |
| MKI67 | marker of proliferation Ki-67 | 0.0302912 |
| ANXA2 | annexin A2 | 0.029874 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0297887 |
| SDC4 | syndecan 4 | 0.029719 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0294699 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0293935 |
| MYO10 | myosin X | 0.029231 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0286262 |
| ENO1 | enolase 1, (alpha) | 0.0285781 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0283748 |
| VCAN | versican | 0.0282243 |
| RPL26 | ribosomal protein L26 | 0.0279092 |
| MLPH | melanophilin | 0.0275949 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0275739 |
| VMP1 | vacuole membrane protein 1 | 0.0273776 |
| RPL27 | ribosomal protein L27 | 0.0272641 |
| ATF4 | activating transcription factor 4 | 0.0269463 |
| RPL14 | ribosomal protein L14 | 0.0263204 |
| NCKAP1 | NCK-associated protein 1 | 0.0260587 |
| AFDN | afadin, adherens junction formation factor | 0.0259549 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0258096 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0257218 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0256656 |
| DSPP | dentin sialophosphoprotein | 0.0254161 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0253507 |
| INTS6 | integrator complex subunit 6 | 0.0252529 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0251464 |
| DUSP10 | dual specificity phosphatase 10 | 0.0251213 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.14801 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.138643 |
| TMSB10 | thymosin beta 10 | -0.124023 |
| RPL35A | ribosomal protein L35a | -0.118338 |
| FN1 | fibronectin 1 | -0.114313 |
| EGR1 | early growth response 1 | -0.101388 |
| VIM | vimentin | -0.0968978 |
| NDRG1 | N-myc downstream regulated 1 | -0.0934523 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0926208 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0721155 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0700711 |
| GNAS | GNAS complex locus | -0.0654842 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0575977 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0565499 |
| FNDC3B | fibronectin type III domain containing 3B | -0.055799 |
| MT2A | metallothionein 2A | -0.0540592 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0534798 |
| VCL | vinculin | -0.0533908 |
| BICC1 | BicC family RNA binding protein 1 | -0.0521034 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0518006 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0491835 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0491019 |
| GLIS3 | GLIS family zinc finger 3 | -0.044665 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0438449 |
| PLIN2 | perilipin 2 | -0.0423958 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0421064 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0420672 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0416047 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0415382 |
| KLF6 | Kruppel-like factor 6 | -0.0400039 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0380537 |
| EXT1 | exostosin glycosyltransferase 1 | -0.036179 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0361184 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0361013 |
| NKTR | natural killer cell triggering receptor | -0.0360975 |
| RPS19 | ribosomal protein S19 | -0.0360252 |
| ACTG1 | actin gamma 1 | -0.0356129 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0355139 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0340989 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0338719 |
| RPLP1 | ribosomal protein, large, P1 | -0.0334893 |
| HMGA1 | high mobility group AT-hook 1 | -0.0332329 |
| TAPBP | TAP binding protein (tapasin) | -0.0329472 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0328524 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0317704 |
| DIAPH2 | diaphanous-related formin 2 | -0.0313223 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0312545 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0308451 |
| RTN4 | reticulon 4 | -0.0305368 |
| DEK | DEK proto-oncogene | -0.0297546 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.029722 |
| MORF4L2 | mortality factor 4 like 2 | -0.0293269 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.029242 |
| TPM4 | tropomyosin 4 | -0.028956 |
| RPS6 | ribosomal protein S6 | -0.0285672 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.028416 |
| RNF213 | ring finger protein 213 | -0.0282724 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0272109 |
| TUBB | tubulin, beta class I | -0.0270188 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0267303 |
| RPL32 | ribosomal protein L32 | -0.0266568 |
| CDCP1 | CUB domain containing protein 1 | -0.0265908 |
| TNNC1 | troponin C type 1 (slow) | -0.0262836 |
| TXNIP | thioredoxin interacting protein | -0.025543 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0255318 |
| TMEM123 | transmembrane protein 123 | -0.0252915 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0251445 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0247428 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0246753 |
| ARF4 | ADP-ribosylation factor 4 | -0.0244142 |
| NABP1 | nucleic acid binding protein 1 | -0.0243213 |
| GPC6 | glypican 6 | -0.0241947 |
| RRBP1 | ribosome binding protein 1 | -0.0240775 |
| OSMR | oncostatin M receptor | -0.0237034 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0233767 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0230289 |
| RPL39 | ribosomal protein L39 | -0.0228147 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0224914 |
| RPS20 | ribosomal protein S20 | -0.0224667 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0224326 |
| COL1A1 | collagen, type I, alpha 1 | -0.0223978 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0222198 |
| CDC27 | cell division cycle 27 | -0.0218844 |
| ATXN1 | ataxin 1 | -0.0217492 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0216281 |
| FOSL1 | FOS-like antigen 1 | -0.0213996 |
| RPL34 | ribosomal protein L34 | -0.0212761 |
| ARF1 | ADP-ribosylation factor 1 | -0.0211812 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0211597 |
| FTL | ferritin, light polypeptide | -0.021138 |
| CADM1 | cell adhesion molecule 1 | -0.0209989 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0208168 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0207466 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0205555 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0205138 |
| RPS24 | ribosomal protein S24 | -0.0204189 |
| SBF2 | SET binding factor 2 | -0.0203731 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0201876 |
| FAM3C | family with sequence similarity 3, member C | -0.0198306 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0195701 |
