| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.112543 |
| B2M | beta-2-microglobulin | 0.109901 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.108232 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.102724 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0976374 |
| UBC | ubiquitin C | 0.0832391 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0709795 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.070471 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0663738 |
| KYNU | kynureninase | 0.0645043 |
| AHNAK | AHNAK nucleoprotein | 0.0633606 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0633447 |
| PRSS23 | protease, serine, 23 | 0.0630513 |
| CALR | calreticulin | 0.063043 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.062816 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0560244 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0539381 |
| IL6 | interleukin 6 | 0.0532119 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.052933 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0497504 |
| ATP13A3 | ATPase type 13A3 | 0.0481923 |
| RPS12 | ribosomal protein S12 | 0.0481587 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0480909 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0480181 |
| ARRDC3 | arrestin domain containing 3 | 0.0466744 |
| FAM13A | family with sequence similarity 13, member A | 0.0461016 |
| MAP1B | microtubule-associated protein 1B | 0.0454423 |
| RPL3 | ribosomal protein L3 | 0.0450183 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0439134 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0437728 |
| EFNA5 | ephrin-A5 | 0.0434953 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0425041 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0424158 |
| NAV1 | neuron navigator 1 | 0.0413379 |
| CDH13 | cadherin 13 | 0.0410498 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0409584 |
| LOX | lysyl oxidase | 0.0401836 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0401069 |
| RPS3 | ribosomal protein S3 | 0.0393603 |
| SDC4 | syndecan 4 | 0.0393104 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0384784 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0382371 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0377022 |
| SON | SON DNA binding protein | 0.0367534 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0361393 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0359343 |
| TMSB4X | thymosin beta 4, X-linked | 0.0355659 |
| LOXL2 | lysyl oxidase-like 2 | 0.0353494 |
| PRICKLE2 | prickle homolog 2 (Drosophila) | 0.0344904 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.034353 |
| ANO6 | anoctamin 6 | 0.0342057 |
| CD44 | CD44 molecule (Indian blood group) | 0.0339374 |
| PGK1 | phosphoglycerate kinase 1 | 0.0335741 |
| DIDO1 | death inducer-obliterator 1 | 0.0332255 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0331664 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0325486 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.031937 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0317574 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0316652 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0315439 |
| SEPTIN9 | septin 9 | 0.0312737 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0309323 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.030928 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0309219 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0307864 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0302905 |
| MMP2 | matrix metallopeptidase 2 | 0.0301604 |
| PDGFC | platelet derived growth factor C | 0.0297232 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0296893 |
| THBS1 | thrombospondin 1 | 0.0295332 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0292615 |
| ANXA1 | annexin A1 | 0.0290672 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0289712 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0288821 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0287502 |
| FAM114A1 | family with sequence similarity 114, member A1 | 0.0286035 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0285309 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0284764 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0282439 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0280528 |
| MYO10 | myosin X | 0.0277082 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0272734 |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.0272347 |
| OXSR1 | oxidative stress responsive 1 | 0.0272064 |
| MATR3 | matrin 3 | 0.0270792 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0267869 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0266588 |
| STC2 | stanniocalcin 2 | 0.0263469 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0261415 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0260533 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.0260297 |
| WDR41 | WD repeat domain 41 | 0.0260054 |
| LDHA | lactate dehydrogenase A | 0.0257318 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0256934 |
| ANXA2 | annexin A2 | 0.0256933 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0256478 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0255274 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0252843 |
| MYLK | myosin light chain kinase | 0.0251449 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0251351 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.228322 |
| NDRG1 | N-myc downstream regulated 1 | -0.134843 |
| FN1 | fibronectin 1 | -0.105782 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.105447 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0942667 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0886168 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0812132 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0754552 |
| GLG1 | golgi glycoprotein 1 | -0.0730867 |
| MT2A | metallothionein 2A | -0.0662947 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0610085 |
| VCL | vinculin | -0.058276 |
| RTN4 | reticulon 4 | -0.0575949 |
| JMJD1C | jumonji domain containing 1C | -0.0571945 |
| HDLBP | high density lipoprotein binding protein | -0.0571673 |
| COL1A2 | collagen, type I, alpha 2 | -0.0567914 |
| COL1A1 | collagen, type I, alpha 1 | -0.0560382 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.055184 |
| MEF2A | myocyte enhancer factor 2A | -0.0547997 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0545747 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.054537 |
| EGR1 | early growth response 1 | -0.0544975 |
| COG5 | component of oligomeric golgi complex 5 | -0.0544493 |
| ZNF395 | zinc finger protein 395 | -0.0537809 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0532788 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0527331 |
| GOLGA4 | golgin A4 | -0.0523333 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0522775 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0508664 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0493464 |
| CLTC | clathrin, heavy chain (Hc) | -0.0488749 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0464519 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0463026 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0460912 |
| SEC24D | SEC24 family member D | -0.0458921 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0453723 |
| GNAS | GNAS complex locus | -0.044518 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0441875 |
| POTEF | POTE ankyrin domain family, member F | -0.0429466 |
| CCDC88A | coiled-coil domain containing 88A | -0.0429075 |
| TOP1 | topoisomerase (DNA) I | -0.0422649 |
| RNF216 | ring finger protein 216 | -0.0411402 |
| SNX14 | sorting nexin 14 | -0.0399855 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0389666 |
| CLIC4 | chloride intracellular channel 4 | -0.0386368 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0384153 |
| TMSB10 | thymosin beta 10 | -0.0375832 |
| GLIS3 | GLIS family zinc finger 3 | -0.0370215 |
| PTMA | prothymosin, alpha | -0.0370088 |
| OGA | O-GlcNAcase | -0.0365881 |
| SMYD3 | SET and MYND domain containing 3 | -0.0365385 |
| ASPH | aspartate beta-hydroxylase | -0.036518 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0362648 |
| FUS | FUS RNA binding protein | -0.0357908 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0357323 |
| PFN1 | profilin 1 | -0.0356359 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0356291 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0355131 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.034971 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0341734 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0340983 |
| FTL | ferritin, light polypeptide | -0.034092 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0340493 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0338951 |
| SRPK2 | SRSF protein kinase 2 | -0.0337315 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0337123 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0335218 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0333146 |
| TMEM165 | transmembrane protein 165 | -0.0325573 |
| ITM2B | integral membrane protein 2B | -0.0325572 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0324373 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0322902 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0318534 |
| SETD5 | SET domain containing 5 | -0.0316326 |
| CDK6 | cyclin-dependent kinase 6 | -0.0316147 |
| CRLS1 | cardiolipin synthase 1 | -0.0314334 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0310745 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0307353 |
| CFDP1 | craniofacial development protein 1 | -0.0306397 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0304123 |
| UBAP2 | ubiquitin associated protein 2 | -0.0299937 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0298363 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0297533 |
| ZNF207 | zinc finger protein 207 | -0.0297412 |
| EGFR | epidermal growth factor receptor | -0.0296187 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0292474 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0292459 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0290824 |
| BSG | basigin (Ok blood group) | -0.0290152 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0289838 |
| SPAG9 | sperm associated antigen 9 | -0.0289074 |
| TMEM41B | transmembrane protein 41B | -0.028836 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.028725 |
| FRMD4A | FERM domain containing 4A | -0.0284863 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0284133 |
| TNNC1 | troponin C type 1 (slow) | -0.0283841 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0279963 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0279011 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0277712 |
| RRBP1 | ribosome binding protein 1 | -0.0276536 |
