| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Adagrasib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0933933 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0923372 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0856133 |
| SDC4 | syndecan 4 | 0.0819603 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0769348 |
| LDHA | lactate dehydrogenase A | 0.0727036 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0717569 |
| AHNAK | AHNAK nucleoprotein | 0.0706237 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0634451 |
| CAPRIN2 | caprin family member 2 | 0.0618557 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0610717 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0574998 |
| CALR | calreticulin | 0.0568358 |
| SET | SET nuclear proto-oncogene | 0.0567721 |
| PTMA | prothymosin, alpha | 0.0562926 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0547747 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.053824 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0536495 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.053307 |
| RPL4 | ribosomal protein L4 | 0.053257 |
| FMNL2 | formin-like 2 | 0.0490369 |
| VMP1 | vacuole membrane protein 1 | 0.0487096 |
| MCL1 | myeloid cell leukemia 1 | 0.0475056 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0472383 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0471822 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0432167 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0421477 |
| MKI67 | marker of proliferation Ki-67 | 0.0414344 |
| CEP250 | centrosomal protein 250kDa | 0.0411653 |
| SFTPA2 | surfactant protein A2 | 0.0409168 |
| KIAA1328 | KIAA1328 | 0.0400986 |
| TMF1 | TATA element modulatory factor 1 | 0.0400316 |
| STEAP3 | STEAP family member 3, metalloreductase | 0.039088 |
| INTS6 | integrator complex subunit 6 | 0.038457 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0378993 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0373724 |
| NAV2 | neuron navigator 2 | 0.0364334 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0362299 |
| MED13L | mediator complex subunit 13-like | 0.0359952 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0358175 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0350856 |
| NPTN | neuroplastin | 0.0350444 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0350276 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0345833 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0344642 |
| FLNB | filamin B, beta | 0.0343859 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.034256 |
| UBC | ubiquitin C | 0.0339367 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0335887 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0335382 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0334823 |
| APP | amyloid beta (A4) precursor protein | 0.0334488 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0334116 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0332474 |
| ANO6 | anoctamin 6 | 0.0330794 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0328834 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0328323 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0325627 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0325564 |
| PDE8A | phosphodiesterase 8A | 0.0324032 |
| PHF21A | PHD finger protein 21A | 0.0323911 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0318033 |
| MYO9B | myosin IXB | 0.0317555 |
| RPL3 | ribosomal protein L3 | 0.0317345 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.030267 |
| DSCAM | Down syndrome cell adhesion molecule | 0.029743 |
| GPX4 | glutathione peroxidase 4 | 0.0296633 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0295871 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0295141 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.029268 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0292483 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | 0.029083 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0289199 |
| FAM168A | family with sequence similarity 168, member A | 0.0287688 |
| RPS12 | ribosomal protein S12 | 0.0286769 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0281831 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.02808 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.027988 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0275677 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0273815 |
| YAP1 | Yes-associated protein 1 | 0.027368 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0271636 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0269566 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0269045 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0266942 |
| EZR | ezrin | 0.0264978 |
| MUSK | muscle, skeletal, receptor tyrosine kinase | 0.0264794 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0264291 |
| PHF3 | PHD finger protein 3 | 0.0262648 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0262404 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0260467 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0259741 |
| PPM1A | protein phosphatase, Mg2+/Mn2+ dependent, 1A | 0.0257082 |
| AATF | apoptosis antagonizing transcription factor | 0.0254301 |
| RAD51B | RAD51 paralog B | 0.0254064 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0253402 |
| TMEM39A | transmembrane protein 39A | 0.025273 |
| PGK1 | phosphoglycerate kinase 1 | 0.0251411 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0250822 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0249809 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LOC112694756 | uncharaterized LOC112694756 | -0.12853 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0916399 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0765454 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0665263 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0643144 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0638799 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0633722 |
| RPL35A | ribosomal protein L35a | -0.063184 |
| NKTR | natural killer cell triggering receptor | -0.0631552 |
| GNAS | GNAS complex locus | -0.061557 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0602685 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0583739 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0580491 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0570797 |
| RPLP1 | ribosomal protein, large, P1 | -0.0560568 |
| ZNF207 | zinc finger protein 207 | -0.0533951 |
| TMEM123 | transmembrane protein 123 | -0.052566 |
| RBM39 | RNA binding motif protein 39 | -0.0487771 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0477252 |
| EGR1 | early growth response 1 | -0.047418 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0466326 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0459624 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0457607 |
| TMSB10 | thymosin beta 10 | -0.0442861 |
| IGF2 | insulin-like growth factor 2 | -0.0438244 |
| SNX14 | sorting nexin 14 | -0.0436743 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0434362 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0431031 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0429736 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0428539 |
| SQSTM1 | sequestosome 1 | -0.0426869 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0425799 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0423376 |
| ATM | ATM serine/threonine kinase | -0.0422879 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0416104 |
| ASPH | aspartate beta-hydroxylase | -0.0405964 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.040431 |
| NALCN | sodium leak channel, non selective | -0.0390281 |
| SETD5 | SET domain containing 5 | -0.038354 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.038137 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0371495 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0371419 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0360966 |
| MED17 | mediator complex subunit 17 | -0.0356025 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.034978 |
| TPM4 | tropomyosin 4 | -0.0346628 |
| FAM3C | family with sequence similarity 3, member C | -0.0335771 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0334603 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0334156 |
| RTN3 | reticulon 3 | -0.0331763 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0331025 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0330203 |
| ATF7IP | activating transcription factor 7 interacting protein | -0.032949 |
| SETX | senataxin | -0.0329442 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0328237 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0326201 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | -0.0325962 |
| NOP58 | NOP58 ribonucleoprotein | -0.0323111 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0321132 |
| COLEC11 | collectin sub-family member 11 | -0.0320367 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0316572 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0316503 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0313674 |
| DENND5B | DENN/MADD domain containing 5B | -0.031148 |
| ERBIN | erbb2 interacting protein | -0.0310629 |
| DEK | DEK proto-oncogene | -0.0303933 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0301356 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0300735 |
| CCNH | cyclin H | -0.0299443 |
| MAP1B | microtubule-associated protein 1B | -0.0298799 |
| WDR45B | WD repeat domain 45B | -0.0298325 |
| NDRG1 | N-myc downstream regulated 1 | -0.0298159 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0297519 |
| NUP98 | nucleoporin 98kDa | -0.0297003 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0294504 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0294177 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0293094 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0291745 |
| TMEM14B | transmembrane protein 14B | -0.0287966 |
| ZFAND5 | zinc finger, AN1-type domain 5 | -0.0277132 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0276533 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0275944 |
| SKIL | SKI-like proto-oncogene | -0.0275834 |
| CENPP | centromere protein P | -0.0275653 |
| YBX3 | Y box binding protein 3 | -0.0275494 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0274709 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0271997 |
| AHCTF1 | AT hook containing transcription factor 1 | -0.027124 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0270889 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0270003 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0269284 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0269176 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.0267111 |
| FNIP1 | folliculin interacting protein 1 | -0.026691 |
| CAPN7 | calpain 7 | -0.0266317 |
| TP53 | tumor protein p53 | -0.0266097 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.026607 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0265005 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | -0.0264765 |
| PREPL | prolyl endopeptidase-like | -0.0264549 |
